Oncological challenges in GFAP-positive anaplastic meningioma: a case report and literature review
Abstract Background Meningiomas are typically found in adults, with an average diagnosis age of 66. However, they can occur in children, presenting unique clinical and immunohistochemical characteristics. This report explores a rare pediatric case of anaplastic meningioma, highlighting the diagnosti...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-01-01
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| Series: | Egyptian Pediatric Association Gazette |
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| Online Access: | https://doi.org/10.1186/s43054-025-00346-x |
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| author | Minh Huu Nhat Le Nghia Minh Tran Thinh Linh Ho Ky Vo Pham Quynh-Nhu Le Vo Duy T. K. Huynh Huynh Phuong Thao Do Phat Tuan Nguyen Michael J. Diaz Nhi Huu Hanh Le Han Hong Huynh Dang Nguyen Minh Phuong Tang Nguyen Quoc Khanh Le |
| author_facet | Minh Huu Nhat Le Nghia Minh Tran Thinh Linh Ho Ky Vo Pham Quynh-Nhu Le Vo Duy T. K. Huynh Huynh Phuong Thao Do Phat Tuan Nguyen Michael J. Diaz Nhi Huu Hanh Le Han Hong Huynh Dang Nguyen Minh Phuong Tang Nguyen Quoc Khanh Le |
| author_sort | Minh Huu Nhat Le |
| collection | DOAJ |
| description | Abstract Background Meningiomas are typically found in adults, with an average diagnosis age of 66. However, they can occur in children, presenting unique clinical and immunohistochemical characteristics. This report explores a rare pediatric case of anaplastic meningioma, highlighting the diagnostic and treatment challenges involved. Clinical finding, lab result, image result, histopathology result This patient’s clinical presentation and imaging studies suggested an intracranial tumor. Histopathological and immunohistochemical analyses confirmed a diagnosis of anaplastic meningioma. Notably, the tumor exhibited rare GFAP positivity, atypical for meningiomas, and a high Ki-67 index, indicating a significant risk of recurrence. Treatment The tumor was successfully removed surgically, and the patient recovered without complications. No additional therapy was planned. Conclusion Surgery is the primary treatment for symptomatic meningiomas, with generally low mortality rates in pediatric cases. This case emphasizes the diagnostic complexity of pediatric meningiomas with atypical features like GFAP positivity. Complete surgical removal of the tumor was performed, in accordance with guidelines. Detailed immunohistochemical analysis is crucial, and further research on similar cases is needed to improve our understanding and treatment strategies. |
| format | Article |
| id | doaj-art-b59e288203b74b9b9823038155049450 |
| institution | Kabale University |
| issn | 2090-9942 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Pediatric Association Gazette |
| spelling | doaj-art-b59e288203b74b9b98230381550494502025-01-26T12:20:07ZengSpringerOpenEgyptian Pediatric Association Gazette2090-99422025-01-0173111110.1186/s43054-025-00346-xOncological challenges in GFAP-positive anaplastic meningioma: a case report and literature reviewMinh Huu Nhat Le0Nghia Minh Tran1Thinh Linh Ho2Ky Vo Pham3Quynh-Nhu Le Vo4Duy T. K. Huynh5Huynh Phuong Thao Do6Phat Tuan Nguyen7Michael J. Diaz8Nhi Huu Hanh Le9Han Hong Huynh10Dang Nguyen11Minh Phuong Tang12Nguyen Quoc Khanh Le13 College of Medicine, Taipei Medical UniversityChildren Hospital No. 1, Department of Radiology, Kien Giang General HospitalDepartment of Neurosurgery, Kien Giang General HospitalFaculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh CityFaculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh CityFaculty of Medicine, Can Tho University of Medicine and PharmacyCardiovascular Research Department, Methodist HospitalCollege of Medicine, University of FloridaFaculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh CityInternational Master Program for Translational Science, College of Medical Science and Technology, Taipei Medical UniversityMassachusetts General Hospital, Corrigan Minehan Heart Center, Harvard Medical SchoolGeneral Surgical Department, Tra Vinh General HospitalResearch Center for Artificial Intelligence in Medicine, Taipei Medical UniversityAbstract Background Meningiomas are typically found in adults, with an average diagnosis age of 66. However, they can occur in children, presenting unique clinical and immunohistochemical characteristics. This report explores a rare pediatric case of anaplastic meningioma, highlighting the diagnostic and treatment challenges involved. Clinical finding, lab result, image result, histopathology result This patient’s clinical presentation and imaging studies suggested an intracranial tumor. Histopathological and immunohistochemical analyses confirmed a diagnosis of anaplastic meningioma. Notably, the tumor exhibited rare GFAP positivity, atypical for meningiomas, and a high Ki-67 index, indicating a significant risk of recurrence. Treatment The tumor was successfully removed surgically, and the patient recovered without complications. No additional therapy was planned. Conclusion Surgery is the primary treatment for symptomatic meningiomas, with generally low mortality rates in pediatric cases. This case emphasizes the diagnostic complexity of pediatric meningiomas with atypical features like GFAP positivity. Complete surgical removal of the tumor was performed, in accordance with guidelines. Detailed immunohistochemical analysis is crucial, and further research on similar cases is needed to improve our understanding and treatment strategies.https://doi.org/10.1186/s43054-025-00346-xIntracranial tumorAnaplastic meningiomaGlial fibrillary acidic protein (GFAP)Malignant meningioma |
| spellingShingle | Minh Huu Nhat Le Nghia Minh Tran Thinh Linh Ho Ky Vo Pham Quynh-Nhu Le Vo Duy T. K. Huynh Huynh Phuong Thao Do Phat Tuan Nguyen Michael J. Diaz Nhi Huu Hanh Le Han Hong Huynh Dang Nguyen Minh Phuong Tang Nguyen Quoc Khanh Le Oncological challenges in GFAP-positive anaplastic meningioma: a case report and literature review Egyptian Pediatric Association Gazette Intracranial tumor Anaplastic meningioma Glial fibrillary acidic protein (GFAP) Malignant meningioma |
| title | Oncological challenges in GFAP-positive anaplastic meningioma: a case report and literature review |
| title_full | Oncological challenges in GFAP-positive anaplastic meningioma: a case report and literature review |
| title_fullStr | Oncological challenges in GFAP-positive anaplastic meningioma: a case report and literature review |
| title_full_unstemmed | Oncological challenges in GFAP-positive anaplastic meningioma: a case report and literature review |
| title_short | Oncological challenges in GFAP-positive anaplastic meningioma: a case report and literature review |
| title_sort | oncological challenges in gfap positive anaplastic meningioma a case report and literature review |
| topic | Intracranial tumor Anaplastic meningioma Glial fibrillary acidic protein (GFAP) Malignant meningioma |
| url | https://doi.org/10.1186/s43054-025-00346-x |
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