Correlation of Clinical, Endoscopic, and Pathological Findings among Suspected Peptic Ulcer Disease Patients in Abuja, Nigeria
Background. Peptic ulcer disease (PUD) remains one of the most prevalent gastrointestinal diseases and has been linked to Helicobacter pylori (H. pylori) infection. This condition may be suspected on clinical grounds, but diagnosis is established using upper gastrointestinal endoscopy. Aims. To dete...
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| Format: | Article |
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Wiley
2021-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2021/9646932 |
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| author | Onyedika Godfrey Okoye Oluwole Olayemi Olaomi Alexander M.E. Nwofor Paul Jibrin Cephas Shallangwa Batta Abubakar Gagarawa Yaú Olawale A. Badejo |
| author_facet | Onyedika Godfrey Okoye Oluwole Olayemi Olaomi Alexander M.E. Nwofor Paul Jibrin Cephas Shallangwa Batta Abubakar Gagarawa Yaú Olawale A. Badejo |
| author_sort | Onyedika Godfrey Okoye |
| collection | DOAJ |
| description | Background. Peptic ulcer disease (PUD) remains one of the most prevalent gastrointestinal diseases and has been linked to Helicobacter pylori (H. pylori) infection. This condition may be suspected on clinical grounds, but diagnosis is established using upper gastrointestinal endoscopy. Aims. To determine the correlation between the endoscopic and pathological findings among suspected PUD patients who have been referred for diagnostic upper gastrointestinal endoscopy in National Hospital Abuja. Methods. This is a hospital-based prospective study conducted among suspected PUD patients at National Hospital Abuja over a one-year period. Clinical, endoscopic, and histological findings were ascertained and documented. Data obtained were analyzed using SPSS version 21.0. Tests of significance were done using the chi-square test and Student t-test at 95% confidence intervals. Results. One hundred and thirty-two patients were included in the study. The ages ranged from 15 to 87 years, mean age 43.30±11.94 years. Seventy-seven (58.3%) patients had abnormal endoscopic findings, of whom 37 (28.0%) had PUD. Prevalence of H. pylori infection was 42.2% and was found in 81.1% of PUD patients. H. pylori was significantly associated with confirmed PUD (p<0.001) and abnormal endoscopic findings (p<0.001). No association was found between normal endoscopic findings and histological findings (p=0.924). Conclusion. There is a poor correlation between clinical and endoscopic diagnoses of PUD. H. pylori was found to be significantly associated with PUD and abnormal endoscopic findings. Endoscopic facilities should therefore be made available and accessible for proper PUD diagnosis. Empirical treatment of H. pylori in patients with diagnosed PUD is strongly recommended. |
| format | Article |
| id | doaj-art-b59bfa3c13214748979135d108f0b04c |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-b59bfa3c13214748979135d108f0b04c2025-02-03T01:25:18ZengWileyGastroenterology Research and Practice1687-61211687-630X2021-01-01202110.1155/2021/96469329646932Correlation of Clinical, Endoscopic, and Pathological Findings among Suspected Peptic Ulcer Disease Patients in Abuja, NigeriaOnyedika Godfrey Okoye0Oluwole Olayemi Olaomi1Alexander M.E. Nwofor2Paul Jibrin3Cephas Shallangwa Batta4Abubakar Gagarawa Yaú5Olawale A. Badejo6Department of Surgery, National Hospital Abuja, NigeriaDepartment of Surgery, National Hospital Abuja, NigeriaDepartment of Surgery, Nnamdi Azikiwe University Teaching Hospital, Nnewi, NigeriaDepartment of Histopathology, National Hospital Abuja, NigeriaDepartment of Surgery, National Hospital Abuja, NigeriaDepartment of Surgery, National Hospital Abuja, NigeriaDepartment of Surgery, National Hospital Abuja, NigeriaBackground. Peptic ulcer disease (PUD) remains one of the most prevalent gastrointestinal diseases and has been linked to Helicobacter pylori (H. pylori) infection. This condition may be suspected on clinical grounds, but diagnosis is established using upper gastrointestinal endoscopy. Aims. To determine the correlation between the endoscopic and pathological findings among suspected PUD patients who have been referred for diagnostic upper gastrointestinal endoscopy in National Hospital Abuja. Methods. This is a hospital-based prospective study conducted among suspected PUD patients at National Hospital Abuja over a one-year period. Clinical, endoscopic, and histological findings were ascertained and documented. Data obtained were analyzed using SPSS version 21.0. Tests of significance were done using the chi-square test and Student t-test at 95% confidence intervals. Results. One hundred and thirty-two patients were included in the study. The ages ranged from 15 to 87 years, mean age 43.30±11.94 years. Seventy-seven (58.3%) patients had abnormal endoscopic findings, of whom 37 (28.0%) had PUD. Prevalence of H. pylori infection was 42.2% and was found in 81.1% of PUD patients. H. pylori was significantly associated with confirmed PUD (p<0.001) and abnormal endoscopic findings (p<0.001). No association was found between normal endoscopic findings and histological findings (p=0.924). Conclusion. There is a poor correlation between clinical and endoscopic diagnoses of PUD. H. pylori was found to be significantly associated with PUD and abnormal endoscopic findings. Endoscopic facilities should therefore be made available and accessible for proper PUD diagnosis. Empirical treatment of H. pylori in patients with diagnosed PUD is strongly recommended.http://dx.doi.org/10.1155/2021/9646932 |
| spellingShingle | Onyedika Godfrey Okoye Oluwole Olayemi Olaomi Alexander M.E. Nwofor Paul Jibrin Cephas Shallangwa Batta Abubakar Gagarawa Yaú Olawale A. Badejo Correlation of Clinical, Endoscopic, and Pathological Findings among Suspected Peptic Ulcer Disease Patients in Abuja, Nigeria Gastroenterology Research and Practice |
| title | Correlation of Clinical, Endoscopic, and Pathological Findings among Suspected Peptic Ulcer Disease Patients in Abuja, Nigeria |
| title_full | Correlation of Clinical, Endoscopic, and Pathological Findings among Suspected Peptic Ulcer Disease Patients in Abuja, Nigeria |
| title_fullStr | Correlation of Clinical, Endoscopic, and Pathological Findings among Suspected Peptic Ulcer Disease Patients in Abuja, Nigeria |
| title_full_unstemmed | Correlation of Clinical, Endoscopic, and Pathological Findings among Suspected Peptic Ulcer Disease Patients in Abuja, Nigeria |
| title_short | Correlation of Clinical, Endoscopic, and Pathological Findings among Suspected Peptic Ulcer Disease Patients in Abuja, Nigeria |
| title_sort | correlation of clinical endoscopic and pathological findings among suspected peptic ulcer disease patients in abuja nigeria |
| url | http://dx.doi.org/10.1155/2021/9646932 |
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