Intestinal schistosomiasis in remote areas of Southwest Ethiopia, a target region for large-scale mass drug administration
Abstract As 2030 approaches, the World Health Organization’s due date for ending intestinal schistosomiasis as a public health problem in all endemic areas, understanding the current trends in the burden of schistosomiasis among schoolchildren in endemic areas is critical for monitoring the progress...
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| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-84987-9 |
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| author | Yared Nigusu Teshome Bekana Eshetu Chilo Sisay Teferi Dereje Oljira Donacho Dereje Gemeda Tefera Darge Abeza Mitiku Abdi Geda Gedefa Tadesse Sime Wubishet Gezimu Oda Gizaw Gemechu Tadila Miressa Bekana Berhanu Erko |
| author_facet | Yared Nigusu Teshome Bekana Eshetu Chilo Sisay Teferi Dereje Oljira Donacho Dereje Gemeda Tefera Darge Abeza Mitiku Abdi Geda Gedefa Tadesse Sime Wubishet Gezimu Oda Gizaw Gemechu Tadila Miressa Bekana Berhanu Erko |
| author_sort | Yared Nigusu |
| collection | DOAJ |
| description | Abstract As 2030 approaches, the World Health Organization’s due date for ending intestinal schistosomiasis as a public health problem in all endemic areas, understanding the current trends in the burden of schistosomiasis among schoolchildren in endemic areas is critical for monitoring the progress, identifying areas for improvement, and developing strategies to plan for instant response to mitigate the burden of schistosomiasis. From February to April of 2023, 328 students from three primary schools in Southwest Ethiopia participated in an institution-based cross-sectional study in the detection of Schistosoma mansoni. Intestinal schistosomiasis was identified among 242 school children, with a rate of infection of 73.8% (95% CI: (64.8–83.4%)). The rate of infection was higher among study participants aged between 10 and 13 years [AOR = 1.93, 95% CI: (1.1, 3.44). About 75% of the male participants were infected with Schistosoma mansoni [AOR = 0.83, 95% CI (0.49, 1.41). Nearly half (48.1%) of the S. mansoni infections among study participants were identified as heavy infections. More than half of the male study participants (50.3%) infected with Schistosoma mansoni had heavy infection intensity. Of the total female schoolchildren infected with Schistosoma mansoni, about 44.4% had a heavy infection. The prevalence and intensity of infection of Schistosoma mansoni in the study area are significantly noticeable, raising doubts on the effectiveness of the interventional programs or pin-points possible re-infection. Strategies to end the disease as a public health threat, mainly in remote and endemic areas, should consider novel integrated strategies targeting the life cycle of schistosomes besides the large-scale mass drug administration. |
| format | Article |
| id | doaj-art-b598d074fb0e49e3930be05670c2f582 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-b598d074fb0e49e3930be05670c2f5822025-01-19T12:24:36ZengNature PortfolioScientific Reports2045-23222025-01-011511710.1038/s41598-024-84987-9Intestinal schistosomiasis in remote areas of Southwest Ethiopia, a target region for large-scale mass drug administrationYared Nigusu0Teshome Bekana1Eshetu Chilo2Sisay Teferi3Dereje Oljira Donacho4Dereje Gemeda5Tefera Darge6Abeza Mitiku7Abdi Geda Gedefa8Tadesse Sime9Wubishet Gezimu10Oda Gizaw11Gemechu Tadila12Miressa Bekana13Berhanu Erko14Department of Medical Laboratory Science, College of Health Sciences, Mattu UniversityDepartment of Medical Laboratory Science, College of Health Sciences, Mattu UniversityDepartment of Medical Laboratory Science, College of Health Sciences, Mattu UniversityDepartment of Medical Laboratory Science, College of Health Sciences, Mattu UniversityDepartment of Health Informatics, College of Health Sciences, Mattu UniversityDepartment of Biomedical Sciences, College of Health Sciences, Mattu UniversityDepartment of Biomedical Sciences, College of Health Sciences, Mattu UniversityDepartment of Public Health, College of Health Sciences, Mattu UniversityDepartment of Public Health, College of Health Sciences, Mattu UniversityDepartment of Nursing, College of Health Sciences, Mattu UniversityDepartment of Nursing, College of Health Sciences, Mattu UniversityDepartment of Animal Science, College of Agriculture, Mattu UniversityDepartment of Geography and Environmental Studies, College of Social Sciences, Mattu UniversityAklilu Lemma Institute of Pathobiology, Addis Ababa UniversityAklilu Lemma Institute of Pathobiology, Addis Ababa UniversityAbstract As 2030 approaches, the World Health Organization’s due date for ending intestinal schistosomiasis as a public health problem in all endemic areas, understanding the current trends in the burden of schistosomiasis among schoolchildren in endemic areas is critical for monitoring the progress, identifying areas for improvement, and developing strategies to plan for instant response to mitigate the burden of schistosomiasis. From February to April of 2023, 328 students from three primary schools in Southwest Ethiopia participated in an institution-based cross-sectional study in the detection of Schistosoma mansoni. Intestinal schistosomiasis was identified among 242 school children, with a rate of infection of 73.8% (95% CI: (64.8–83.4%)). The rate of infection was higher among study participants aged between 10 and 13 years [AOR = 1.93, 95% CI: (1.1, 3.44). About 75% of the male participants were infected with Schistosoma mansoni [AOR = 0.83, 95% CI (0.49, 1.41). Nearly half (48.1%) of the S. mansoni infections among study participants were identified as heavy infections. More than half of the male study participants (50.3%) infected with Schistosoma mansoni had heavy infection intensity. Of the total female schoolchildren infected with Schistosoma mansoni, about 44.4% had a heavy infection. The prevalence and intensity of infection of Schistosoma mansoni in the study area are significantly noticeable, raising doubts on the effectiveness of the interventional programs or pin-points possible re-infection. Strategies to end the disease as a public health threat, mainly in remote and endemic areas, should consider novel integrated strategies targeting the life cycle of schistosomes besides the large-scale mass drug administration.https://doi.org/10.1038/s41598-024-84987-9Schistosoma mansoniPrevalenceIntensitySouthwest EthiopiaSchoolchildren |
| spellingShingle | Yared Nigusu Teshome Bekana Eshetu Chilo Sisay Teferi Dereje Oljira Donacho Dereje Gemeda Tefera Darge Abeza Mitiku Abdi Geda Gedefa Tadesse Sime Wubishet Gezimu Oda Gizaw Gemechu Tadila Miressa Bekana Berhanu Erko Intestinal schistosomiasis in remote areas of Southwest Ethiopia, a target region for large-scale mass drug administration Scientific Reports Schistosoma mansoni Prevalence Intensity Southwest Ethiopia Schoolchildren |
| title | Intestinal schistosomiasis in remote areas of Southwest Ethiopia, a target region for large-scale mass drug administration |
| title_full | Intestinal schistosomiasis in remote areas of Southwest Ethiopia, a target region for large-scale mass drug administration |
| title_fullStr | Intestinal schistosomiasis in remote areas of Southwest Ethiopia, a target region for large-scale mass drug administration |
| title_full_unstemmed | Intestinal schistosomiasis in remote areas of Southwest Ethiopia, a target region for large-scale mass drug administration |
| title_short | Intestinal schistosomiasis in remote areas of Southwest Ethiopia, a target region for large-scale mass drug administration |
| title_sort | intestinal schistosomiasis in remote areas of southwest ethiopia a target region for large scale mass drug administration |
| topic | Schistosoma mansoni Prevalence Intensity Southwest Ethiopia Schoolchildren |
| url | https://doi.org/10.1038/s41598-024-84987-9 |
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