Gut microbiota-derived metabolite phenylacetylglutamine in cardiovascular and metabolic diseases
The aging of population coupled with unhealthy dietary habits among residents has led to a rise in the incidence of cardiovascular and metabolic diseases (CVMDs). Extensive research has highlighted the role of gut microbiota-derived metabolites in CVMDs. Among these metabolites, phenylacetylglutamin...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-07-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661825002191 |
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| author | Wan Chen Mei-Ling Li Guang Zeng Xiang-Yu Xu Shan-Hui Yin Can Xu Linlin Li Kaikai Wen Xiao-Hua Yu Gang Wang |
| author_facet | Wan Chen Mei-Ling Li Guang Zeng Xiang-Yu Xu Shan-Hui Yin Can Xu Linlin Li Kaikai Wen Xiao-Hua Yu Gang Wang |
| author_sort | Wan Chen |
| collection | DOAJ |
| description | The aging of population coupled with unhealthy dietary habits among residents has led to a rise in the incidence of cardiovascular and metabolic diseases (CVMDs). Extensive research has highlighted the role of gut microbiota-derived metabolites in CVMDs. Among these metabolites, phenylacetylglutamine (PAGln), a meta-organismal prothrombotic metabolite, has been proved to promote the progression of CVMDs. This bacterial derived metabolite is a byproduct of amino acid comes from phenylalanine (Phe) in the diet. There are increasing evidence showing that the level of PAGln is associated with the risk of developing CVMDs. To provide a comprehensive understanding of the role of PAGln in CVMDs, this review delves into the production and metabolic pathways of PAGln and discusses the links of PAGln and the pathogenesis of CVMDs. |
| format | Article |
| id | doaj-art-b58e650beec241c1a58a3ad0c86affcc |
| institution | DOAJ |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-b58e650beec241c1a58a3ad0c86affcc2025-08-20T03:12:05ZengElsevierPharmacological Research1096-11862025-07-0121710779410.1016/j.phrs.2025.107794Gut microbiota-derived metabolite phenylacetylglutamine in cardiovascular and metabolic diseasesWan Chen0Mei-Ling Li1Guang Zeng2Xiang-Yu Xu3Shan-Hui Yin4Can Xu5Linlin Li6Kaikai Wen7Xiao-Hua Yu8Gang Wang9The First Affiliated Hospital, Department of Cardiology, Hengyang Medical school, University of South China, Hengyang, Hunan 421001, China; Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, ChinaThe First Affiliated Hospital, Department of Cardiology, Hengyang Medical school, University of South China, Hengyang, Hunan 421001, ChinaThe First Affiliated Hospital, Department of Cardiology, Hengyang Medical school, University of South China, Hengyang, Hunan 421001, ChinaThe First Affiliated Hospital, Department of Cardiology, Hengyang Medical school, University of South China, Hengyang, Hunan 421001, ChinaThe First Affiliated Hospital, Department of Cardiology, Hengyang Medical school, University of South China, Hengyang, Hunan 421001, ChinaThe First Affiliated Hospital, Department of Cardiology, Hengyang Medical school, University of South China, Hengyang, Hunan 421001, ChinaBeijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, ChinaBeijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China; Corresponding authors.Institute of Clinical Medicine, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570100, China; Corresponding authors.The First Affiliated Hospital, Department of Cardiology, Hengyang Medical school, University of South China, Hengyang, Hunan 421001, China; Corresponding authors.The aging of population coupled with unhealthy dietary habits among residents has led to a rise in the incidence of cardiovascular and metabolic diseases (CVMDs). Extensive research has highlighted the role of gut microbiota-derived metabolites in CVMDs. Among these metabolites, phenylacetylglutamine (PAGln), a meta-organismal prothrombotic metabolite, has been proved to promote the progression of CVMDs. This bacterial derived metabolite is a byproduct of amino acid comes from phenylalanine (Phe) in the diet. There are increasing evidence showing that the level of PAGln is associated with the risk of developing CVMDs. To provide a comprehensive understanding of the role of PAGln in CVMDs, this review delves into the production and metabolic pathways of PAGln and discusses the links of PAGln and the pathogenesis of CVMDs.http://www.sciencedirect.com/science/article/pii/S1043661825002191Cardiovascular diseasesMetabolic diseasesGut microbiotaGut microbiota-derived metabolitePhenylacetylglutamine |
| spellingShingle | Wan Chen Mei-Ling Li Guang Zeng Xiang-Yu Xu Shan-Hui Yin Can Xu Linlin Li Kaikai Wen Xiao-Hua Yu Gang Wang Gut microbiota-derived metabolite phenylacetylglutamine in cardiovascular and metabolic diseases Pharmacological Research Cardiovascular diseases Metabolic diseases Gut microbiota Gut microbiota-derived metabolite Phenylacetylglutamine |
| title | Gut microbiota-derived metabolite phenylacetylglutamine in cardiovascular and metabolic diseases |
| title_full | Gut microbiota-derived metabolite phenylacetylglutamine in cardiovascular and metabolic diseases |
| title_fullStr | Gut microbiota-derived metabolite phenylacetylglutamine in cardiovascular and metabolic diseases |
| title_full_unstemmed | Gut microbiota-derived metabolite phenylacetylglutamine in cardiovascular and metabolic diseases |
| title_short | Gut microbiota-derived metabolite phenylacetylglutamine in cardiovascular and metabolic diseases |
| title_sort | gut microbiota derived metabolite phenylacetylglutamine in cardiovascular and metabolic diseases |
| topic | Cardiovascular diseases Metabolic diseases Gut microbiota Gut microbiota-derived metabolite Phenylacetylglutamine |
| url | http://www.sciencedirect.com/science/article/pii/S1043661825002191 |
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