Donor-derived Scedosporium infection following deceased donor kidney transplantation presenting as endogenous endophthalmitis
Purpose: To describe a novel case of donor-derived scedosporium infection following kidney transplantation presenting as endogenous endophthalmitis. Observations: A 69 year-old male presented with right eye pain and redness for 3 days following deceased donor kidney transplant one month prior. Initi...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
|
| Series: | American Journal of Ophthalmology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451993625000842 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849725140229685248 |
|---|---|
| author | Ryan Duong Alden Doyle Arthi Venkat |
| author_facet | Ryan Duong Alden Doyle Arthi Venkat |
| author_sort | Ryan Duong |
| collection | DOAJ |
| description | Purpose: To describe a novel case of donor-derived scedosporium infection following kidney transplantation presenting as endogenous endophthalmitis. Observations: A 69 year-old male presented with right eye pain and redness for 3 days following deceased donor kidney transplant one month prior. Initial exam showed counting fingers vision, 4+ anterior chamber cell, hypopyon, dense vitritis, and a large white macular lesion. A vitreous tap and inject was performed with intravitreal vancomycin, ceftazidime, and voriconazole. The patient was admitted to the for systemic antimicrobials where infectious workup revealed a psoas abscess and a perinephric donor kidney fluid collection with biopsy of the fluid yielding positive Scedosporium spp. Given his multifocal systemic infection, recent transplantation, and immunosuppression requirements, a review of the donor history was performed and revealed evidence of systemic Scedosporium infection. A diagnosis of donor-derived Scedosporium infection was made. The other transplant centers where the other organs from this donor were used were contacted and each of their recipients were screened, however, no other donor-derived infections were found. Conclusions and importance: Donor derived scedosporium infections can have devastating ophthalmologic and systemic complications in solid organ transplant recipients. Further efforts are warranted to better screen for the risk for deceased donor fungal infections during transplant organ evaluation. |
| format | Article |
| id | doaj-art-b58de9a00b95403ea8f3b4ece7cb27b2 |
| institution | DOAJ |
| issn | 2451-9936 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Ophthalmology Case Reports |
| spelling | doaj-art-b58de9a00b95403ea8f3b4ece7cb27b22025-08-20T03:10:32ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362025-06-013810233110.1016/j.ajoc.2025.102331Donor-derived Scedosporium infection following deceased donor kidney transplantation presenting as endogenous endophthalmitisRyan Duong0Alden Doyle1Arthi Venkat2University of Virginia Dept of Ophthalmology, 1300 Jefferson Park Ave, Charlottesville, VA, USA; Corresponding author. 1300 Jefferson Park Ave, Charlottesville, VA, USA.University of Virginia Dept of Medicine Division of Nephrology, 1300 Jefferson Park Ave, Charlottesville, VA, USAUniversity of Virginia Dept of Ophthalmology, 1300 Jefferson Park Ave, Charlottesville, VA, USAPurpose: To describe a novel case of donor-derived scedosporium infection following kidney transplantation presenting as endogenous endophthalmitis. Observations: A 69 year-old male presented with right eye pain and redness for 3 days following deceased donor kidney transplant one month prior. Initial exam showed counting fingers vision, 4+ anterior chamber cell, hypopyon, dense vitritis, and a large white macular lesion. A vitreous tap and inject was performed with intravitreal vancomycin, ceftazidime, and voriconazole. The patient was admitted to the for systemic antimicrobials where infectious workup revealed a psoas abscess and a perinephric donor kidney fluid collection with biopsy of the fluid yielding positive Scedosporium spp. Given his multifocal systemic infection, recent transplantation, and immunosuppression requirements, a review of the donor history was performed and revealed evidence of systemic Scedosporium infection. A diagnosis of donor-derived Scedosporium infection was made. The other transplant centers where the other organs from this donor were used were contacted and each of their recipients were screened, however, no other donor-derived infections were found. Conclusions and importance: Donor derived scedosporium infections can have devastating ophthalmologic and systemic complications in solid organ transplant recipients. Further efforts are warranted to better screen for the risk for deceased donor fungal infections during transplant organ evaluation.http://www.sciencedirect.com/science/article/pii/S2451993625000842Endogenous endophthalmitisScedosporiumKidney transplant |
| spellingShingle | Ryan Duong Alden Doyle Arthi Venkat Donor-derived Scedosporium infection following deceased donor kidney transplantation presenting as endogenous endophthalmitis American Journal of Ophthalmology Case Reports Endogenous endophthalmitis Scedosporium Kidney transplant |
| title | Donor-derived Scedosporium infection following deceased donor kidney transplantation presenting as endogenous endophthalmitis |
| title_full | Donor-derived Scedosporium infection following deceased donor kidney transplantation presenting as endogenous endophthalmitis |
| title_fullStr | Donor-derived Scedosporium infection following deceased donor kidney transplantation presenting as endogenous endophthalmitis |
| title_full_unstemmed | Donor-derived Scedosporium infection following deceased donor kidney transplantation presenting as endogenous endophthalmitis |
| title_short | Donor-derived Scedosporium infection following deceased donor kidney transplantation presenting as endogenous endophthalmitis |
| title_sort | donor derived scedosporium infection following deceased donor kidney transplantation presenting as endogenous endophthalmitis |
| topic | Endogenous endophthalmitis Scedosporium Kidney transplant |
| url | http://www.sciencedirect.com/science/article/pii/S2451993625000842 |
| work_keys_str_mv | AT ryanduong donorderivedscedosporiuminfectionfollowingdeceaseddonorkidneytransplantationpresentingasendogenousendophthalmitis AT aldendoyle donorderivedscedosporiuminfectionfollowingdeceaseddonorkidneytransplantationpresentingasendogenousendophthalmitis AT arthivenkat donorderivedscedosporiuminfectionfollowingdeceaseddonorkidneytransplantationpresentingasendogenousendophthalmitis |