Progress in photoreceptor replacement therapy for retinal degenerative diseases
Retinal degenerative diseases encompass a diverse range of eye conditions that result in blindness, many due to photoreceptor dysfunction and loss. Regrettably, current clinical treatments are frequently not overly effective. However, photoreceptor transplantation shows promise as a potential therap...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Cell Insight |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772892724000786 |
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| _version_ | 1832582119101038592 |
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| author | Yuxin Du Yin Shen |
| author_facet | Yuxin Du Yin Shen |
| author_sort | Yuxin Du |
| collection | DOAJ |
| description | Retinal degenerative diseases encompass a diverse range of eye conditions that result in blindness, many due to photoreceptor dysfunction and loss. Regrettably, current clinical treatments are frequently not overly effective. However, photoreceptor transplantation shows promise as a potential therapy for late-stage retinal degenerative diseases. This article will review the various donor cell sources for this transplantation, as well as the mechanisms and factors that impact donor cell integration and material transfer, donor cell maturation, and other auxiliary methods that can be combined with photoreceptor transplantation to treat these degenerative retinal diseases. |
| format | Article |
| id | doaj-art-b58b157ea52d42318120a5f6dc07dbe1 |
| institution | Kabale University |
| issn | 2772-8927 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Insight |
| spelling | doaj-art-b58b157ea52d42318120a5f6dc07dbe12025-01-30T05:15:18ZengElsevierCell Insight2772-89272025-02-0141100223Progress in photoreceptor replacement therapy for retinal degenerative diseasesYuxin Du0Yin Shen1Eye Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, ChinaEye Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan 430071, Hubei, China; Corresponding author. Eye Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, ChinaRetinal degenerative diseases encompass a diverse range of eye conditions that result in blindness, many due to photoreceptor dysfunction and loss. Regrettably, current clinical treatments are frequently not overly effective. However, photoreceptor transplantation shows promise as a potential therapy for late-stage retinal degenerative diseases. This article will review the various donor cell sources for this transplantation, as well as the mechanisms and factors that impact donor cell integration and material transfer, donor cell maturation, and other auxiliary methods that can be combined with photoreceptor transplantation to treat these degenerative retinal diseases.http://www.sciencedirect.com/science/article/pii/S2772892724000786Photoreceptor replacementRetinal degenerative diseasesRetinitis pigmentosaNanomaterialsGene therapyPhotoreceptor transplantation |
| spellingShingle | Yuxin Du Yin Shen Progress in photoreceptor replacement therapy for retinal degenerative diseases Cell Insight Photoreceptor replacement Retinal degenerative diseases Retinitis pigmentosa Nanomaterials Gene therapy Photoreceptor transplantation |
| title | Progress in photoreceptor replacement therapy for retinal degenerative diseases |
| title_full | Progress in photoreceptor replacement therapy for retinal degenerative diseases |
| title_fullStr | Progress in photoreceptor replacement therapy for retinal degenerative diseases |
| title_full_unstemmed | Progress in photoreceptor replacement therapy for retinal degenerative diseases |
| title_short | Progress in photoreceptor replacement therapy for retinal degenerative diseases |
| title_sort | progress in photoreceptor replacement therapy for retinal degenerative diseases |
| topic | Photoreceptor replacement Retinal degenerative diseases Retinitis pigmentosa Nanomaterials Gene therapy Photoreceptor transplantation |
| url | http://www.sciencedirect.com/science/article/pii/S2772892724000786 |
| work_keys_str_mv | AT yuxindu progressinphotoreceptorreplacementtherapyforretinaldegenerativediseases AT yinshen progressinphotoreceptorreplacementtherapyforretinaldegenerativediseases |