Endometriosis Gene Expression Heterogeneity and Biosignature: A Phylogenetic Analysis
Endometriosis is a multifactorial disease with poorly understood etiology, and reflecting an evolutionary nature where genetic alterations accumulate throughout pathogenesis. Our objective was to characterize the heterogeneous pathological process using parsimony phylogenetics. Gene expression micro...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2011/719059 |
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| author | Mones Abu-Asab Ming Zhang Dennis Amini Nihad Abu-Asab Hakima Amri |
| author_facet | Mones Abu-Asab Ming Zhang Dennis Amini Nihad Abu-Asab Hakima Amri |
| author_sort | Mones Abu-Asab |
| collection | DOAJ |
| description | Endometriosis is a multifactorial disease with poorly understood etiology, and reflecting an evolutionary nature where genetic alterations accumulate throughout pathogenesis. Our objective was to characterize the heterogeneous pathological process using parsimony phylogenetics. Gene expression microarray data of ovarian endometriosis obtained from NCBI database were polarized and coded into derived (abnormal) and ancestral (normal) states. Such alterations are referred to as synapomorphies in a phylogenetic sense (or biomarkers). Subsequent gene linkage was modeled by Genomatix BiblioSphere Pathway software. A list of clonally shared derived (abnormal) expressions revealed the pattern of heterogeneity among specimens. In addition, it has identified disruptions within the major regulatory pathways including those involved in cell proliferation, steroidogenesis, angiogenesis, cytoskeletal organization and integrity, and tumorigenesis, as well as cell adhesion and migration. Furthermore, the analysis supported the potential central involvement of ESR2 in the initiation of endometriosis. The pathogenesis mapping showed that eutopic and ectopic lesions have different molecular biosignatures. |
| format | Article |
| id | doaj-art-b583a8a506ca456b9198f85763b8b9d8 |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-b583a8a506ca456b9198f85763b8b9d82025-02-03T05:43:58ZengWileyObstetrics and Gynecology International1687-95891687-95972011-01-01201110.1155/2011/719059719059Endometriosis Gene Expression Heterogeneity and Biosignature: A Phylogenetic AnalysisMones Abu-Asab0Ming Zhang1Dennis Amini2Nihad Abu-Asab3Hakima Amri4Laboratory of Immunology, Section of Immunopathology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USADepartment of Biochemistry and Cellular & Molecular Biology, Georgetown University Medical Center, Washington, DC 20007, USADepartment of Obstetrics and Gynecology, Georgetown University Hospital, Washington, DC 20007, USAArmidale Rural Referral Hospital, University of New England and The University of Newcastle, Armidale, NSW 2351, AustraliaDepartment of Biochemistry and Cellular & Molecular Biology, Georgetown University Medical Center, Washington, DC 20007, USAEndometriosis is a multifactorial disease with poorly understood etiology, and reflecting an evolutionary nature where genetic alterations accumulate throughout pathogenesis. Our objective was to characterize the heterogeneous pathological process using parsimony phylogenetics. Gene expression microarray data of ovarian endometriosis obtained from NCBI database were polarized and coded into derived (abnormal) and ancestral (normal) states. Such alterations are referred to as synapomorphies in a phylogenetic sense (or biomarkers). Subsequent gene linkage was modeled by Genomatix BiblioSphere Pathway software. A list of clonally shared derived (abnormal) expressions revealed the pattern of heterogeneity among specimens. In addition, it has identified disruptions within the major regulatory pathways including those involved in cell proliferation, steroidogenesis, angiogenesis, cytoskeletal organization and integrity, and tumorigenesis, as well as cell adhesion and migration. Furthermore, the analysis supported the potential central involvement of ESR2 in the initiation of endometriosis. The pathogenesis mapping showed that eutopic and ectopic lesions have different molecular biosignatures.http://dx.doi.org/10.1155/2011/719059 |
| spellingShingle | Mones Abu-Asab Ming Zhang Dennis Amini Nihad Abu-Asab Hakima Amri Endometriosis Gene Expression Heterogeneity and Biosignature: A Phylogenetic Analysis Obstetrics and Gynecology International |
| title | Endometriosis Gene Expression Heterogeneity and Biosignature: A Phylogenetic Analysis |
| title_full | Endometriosis Gene Expression Heterogeneity and Biosignature: A Phylogenetic Analysis |
| title_fullStr | Endometriosis Gene Expression Heterogeneity and Biosignature: A Phylogenetic Analysis |
| title_full_unstemmed | Endometriosis Gene Expression Heterogeneity and Biosignature: A Phylogenetic Analysis |
| title_short | Endometriosis Gene Expression Heterogeneity and Biosignature: A Phylogenetic Analysis |
| title_sort | endometriosis gene expression heterogeneity and biosignature a phylogenetic analysis |
| url | http://dx.doi.org/10.1155/2011/719059 |
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