Causal relationship between inflammatory bowel disease and sex: a Mendelian randomization study
ObjectiveThe aim of this study was to investigate the bidirectional causal relationship between sex hormones and IBD through a two-sample bidirectional Mendelian randomization (MR) study.MethodsBased on Genome-Wide Association Study (GWAS) pooled data on SHBG, total testosterone, bioavailable testos...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1338701/full |
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| author | Kaiwen Wang Yu Lou Shunjie Tian Zhihui Tao Zhihui Tao |
| author_facet | Kaiwen Wang Yu Lou Shunjie Tian Zhihui Tao Zhihui Tao |
| author_sort | Kaiwen Wang |
| collection | DOAJ |
| description | ObjectiveThe aim of this study was to investigate the bidirectional causal relationship between sex hormones and IBD through a two-sample bidirectional Mendelian randomization (MR) study.MethodsBased on Genome-Wide Association Study (GWAS) pooled data on SHBG, total testosterone, bioavailable testosterone, estradiol, and IBD in a European population, we performed two-sample bidirectional MR analyses using single nucleotide polymorphisms (SNPs) as instrumental variables. We used inverse variance weighting (IVW), weighted median, weighted mode, and MR-Egger to assess bidirectional causality between sex hormones and IBD.ResultsThere was no causal relationship between sex hormones and IBD in women (P > 0.05), and there was a causal and positive correlation between SHBG and testosterone and IBD in men.The OR for SHBG was 1.22 (95% CI: 1.09-1.37, P = 0.0004), and for testosterone was 1.20 (95% CI: 1.04-1.39, P = 0.0145).IBD did not significantly interact with female sex hormones but resulted in a decrease in SHBG (OR = 1.02, 95% CI: 1.00-1.04, P = 0.0195) and testosterone (OR = 1.01, 95% CI: 1.00 -1.02, P = 0.0200) in men.ConclusionThere is no causal relationship between female sex hormones and IBD, but male SHBG and testosterone are positively correlated with the risk of IBD and IBD promotes elevated levels of SHBG and testosterone in males, suggesting that sex hormones play different roles in IBD patients of different sexes. |
| format | Article |
| id | doaj-art-b571c172d2fb4db7b69ded9d440cd839 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-b571c172d2fb4db7b69ded9d440cd8392025-01-29T05:21:32ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011610.3389/fendo.2025.13387011338701Causal relationship between inflammatory bowel disease and sex: a Mendelian randomization studyKaiwen Wang0Yu Lou1Shunjie Tian2Zhihui Tao3Zhihui Tao4Department of Oncology, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Oncology, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Oncology, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaObjectiveThe aim of this study was to investigate the bidirectional causal relationship between sex hormones and IBD through a two-sample bidirectional Mendelian randomization (MR) study.MethodsBased on Genome-Wide Association Study (GWAS) pooled data on SHBG, total testosterone, bioavailable testosterone, estradiol, and IBD in a European population, we performed two-sample bidirectional MR analyses using single nucleotide polymorphisms (SNPs) as instrumental variables. We used inverse variance weighting (IVW), weighted median, weighted mode, and MR-Egger to assess bidirectional causality between sex hormones and IBD.ResultsThere was no causal relationship between sex hormones and IBD in women (P > 0.05), and there was a causal and positive correlation between SHBG and testosterone and IBD in men.The OR for SHBG was 1.22 (95% CI: 1.09-1.37, P = 0.0004), and for testosterone was 1.20 (95% CI: 1.04-1.39, P = 0.0145).IBD did not significantly interact with female sex hormones but resulted in a decrease in SHBG (OR = 1.02, 95% CI: 1.00-1.04, P = 0.0195) and testosterone (OR = 1.01, 95% CI: 1.00 -1.02, P = 0.0200) in men.ConclusionThere is no causal relationship between female sex hormones and IBD, but male SHBG and testosterone are positively correlated with the risk of IBD and IBD promotes elevated levels of SHBG and testosterone in males, suggesting that sex hormones play different roles in IBD patients of different sexes.https://www.frontiersin.org/articles/10.3389/fendo.2025.1338701/fullsex hormoneIBDMendelian randomizationgenome-wide associationbiomarker |
| spellingShingle | Kaiwen Wang Yu Lou Shunjie Tian Zhihui Tao Zhihui Tao Causal relationship between inflammatory bowel disease and sex: a Mendelian randomization study Frontiers in Endocrinology sex hormone IBD Mendelian randomization genome-wide association biomarker |
| title | Causal relationship between inflammatory bowel disease and sex: a Mendelian randomization study |
| title_full | Causal relationship between inflammatory bowel disease and sex: a Mendelian randomization study |
| title_fullStr | Causal relationship between inflammatory bowel disease and sex: a Mendelian randomization study |
| title_full_unstemmed | Causal relationship between inflammatory bowel disease and sex: a Mendelian randomization study |
| title_short | Causal relationship between inflammatory bowel disease and sex: a Mendelian randomization study |
| title_sort | causal relationship between inflammatory bowel disease and sex a mendelian randomization study |
| topic | sex hormone IBD Mendelian randomization genome-wide association biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1338701/full |
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