Prolonged fecal shedding of replication-competent virus, lasting immune activation, and intestinal inflammation in a rhesus macaque after experimental SARS-CoV-2 infection

Prolonged fecal shedding of replication-competent virus, lasting immune activation, and intestinal inflammation in a rhesus macaque after experimental SARS-CoV-2 infection

Infection of an adult rhesus macaque with SARS-CoV-2 led to viral RNAemia in nose, throat, and lungs. The animal also presented extended fecal shedding of viral genomic and subgenomic messenger RNA and replication-competent virus for more than 3 weeks after infection. Positron emission tomography re...

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Bibliographic Details
Main Authors: Kinga P. Böszörményi, Marieke A. Stammes, Zahra Fagrouch, Fidel Acar, Henk Niphuis, Gwendoline Kiemenyi Kayere, Lisette Meijer, Eric J. Snijder, Lia van der Hoek, Ben Berkhout, Willy M. Bogers, Judith M. A. van den Brand, Ivanela Kondova, Babs E. Verstrepen, Ernst J. Verschoor
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
SARS-CoV-2
COVID-19
rhesus macaque
virus shedding
PET-CT
intestinal inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2024.1505720/full
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