Tumor-Related Exosomes Contribute to Tumor-Promoting Microenvironment: An Immunological Perspective
Exosomes are a kind of cell-released membrane-form structures which contain proteins, lipids, and nucleic acids. These vesicular organelles play a key role in intercellular communication. Numerous experiments demonstrated that tumor-related exosomes (TEXs) can induce immune surveillance in the micro...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/1073947 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556213793980416 |
|---|---|
| author | Wuzhen Chen Jingxin Jiang Wenjie Xia Jian Huang |
| author_facet | Wuzhen Chen Jingxin Jiang Wenjie Xia Jian Huang |
| author_sort | Wuzhen Chen |
| collection | DOAJ |
| description | Exosomes are a kind of cell-released membrane-form structures which contain proteins, lipids, and nucleic acids. These vesicular organelles play a key role in intercellular communication. Numerous experiments demonstrated that tumor-related exosomes (TEXs) can induce immune surveillance in the microenvironment in vivo and in vitro. They can interfere with the maturation of DC cells, impair NK cell activation, induce myeloid-derived suppressor cells, and educate macrophages into protumor phenotype. They can also selectively induce effector T cell apoptosis via Fas/FasL interaction and enhance regulatory T cell proliferation and function by releasing TGF-β. In this review, we focus on the TEX-induced immunosuppression and microenvironment change. Based on the truth that TEXs play crucial roles in suppressing the immune system, studies on modification of exosomes as immunotherapy strategies will also be discussed. |
| format | Article |
| id | doaj-art-b55a0aa29e084d619c4ef9bb5ed66408 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-b55a0aa29e084d619c4ef9bb5ed664082025-02-03T05:45:58ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/10739471073947Tumor-Related Exosomes Contribute to Tumor-Promoting Microenvironment: An Immunological PerspectiveWuzhen Chen0Jingxin Jiang1Wenjie Xia2Jian Huang3Department of Surgical Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Surgical Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Surgical Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Surgical Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaExosomes are a kind of cell-released membrane-form structures which contain proteins, lipids, and nucleic acids. These vesicular organelles play a key role in intercellular communication. Numerous experiments demonstrated that tumor-related exosomes (TEXs) can induce immune surveillance in the microenvironment in vivo and in vitro. They can interfere with the maturation of DC cells, impair NK cell activation, induce myeloid-derived suppressor cells, and educate macrophages into protumor phenotype. They can also selectively induce effector T cell apoptosis via Fas/FasL interaction and enhance regulatory T cell proliferation and function by releasing TGF-β. In this review, we focus on the TEX-induced immunosuppression and microenvironment change. Based on the truth that TEXs play crucial roles in suppressing the immune system, studies on modification of exosomes as immunotherapy strategies will also be discussed.http://dx.doi.org/10.1155/2017/1073947 |
| spellingShingle | Wuzhen Chen Jingxin Jiang Wenjie Xia Jian Huang Tumor-Related Exosomes Contribute to Tumor-Promoting Microenvironment: An Immunological Perspective Journal of Immunology Research |
| title | Tumor-Related Exosomes Contribute to Tumor-Promoting Microenvironment: An Immunological Perspective |
| title_full | Tumor-Related Exosomes Contribute to Tumor-Promoting Microenvironment: An Immunological Perspective |
| title_fullStr | Tumor-Related Exosomes Contribute to Tumor-Promoting Microenvironment: An Immunological Perspective |
| title_full_unstemmed | Tumor-Related Exosomes Contribute to Tumor-Promoting Microenvironment: An Immunological Perspective |
| title_short | Tumor-Related Exosomes Contribute to Tumor-Promoting Microenvironment: An Immunological Perspective |
| title_sort | tumor related exosomes contribute to tumor promoting microenvironment an immunological perspective |
| url | http://dx.doi.org/10.1155/2017/1073947 |
| work_keys_str_mv | AT wuzhenchen tumorrelatedexosomescontributetotumorpromotingmicroenvironmentanimmunologicalperspective AT jingxinjiang tumorrelatedexosomescontributetotumorpromotingmicroenvironmentanimmunologicalperspective AT wenjiexia tumorrelatedexosomescontributetotumorpromotingmicroenvironmentanimmunologicalperspective AT jianhuang tumorrelatedexosomescontributetotumorpromotingmicroenvironmentanimmunologicalperspective |