The role of activated partial thrombin time in mediating the impact of poorly glycemic control on diabetic peripheral neuropathy in patients with type 2 diabetes mellitus
AimThis study aims to investigate the role of activated partial thrombin time (APTT) as a potential mediator in the relationship between suboptimal glycemic control and diabetic peripheral neuropathy (DPN) in individuals with type 2 diabetes mellitus (T2DM).MethodsA total of 183 T2DM patients were e...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1501323/full |
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| author | Hui Zhang Minghui Chen Lijie Sun Wenwen Zhu Wenwen Zhu Tong Niu Huzaifa Fareeduddin Mohammmed Farooqui Hongxiao Wang Bing Song Jumei Wang Haoqiang Zhang |
| author_facet | Hui Zhang Minghui Chen Lijie Sun Wenwen Zhu Wenwen Zhu Tong Niu Huzaifa Fareeduddin Mohammmed Farooqui Hongxiao Wang Bing Song Jumei Wang Haoqiang Zhang |
| author_sort | Hui Zhang |
| collection | DOAJ |
| description | AimThis study aims to investigate the role of activated partial thrombin time (APTT) as a potential mediator in the relationship between suboptimal glycemic control and diabetic peripheral neuropathy (DPN) in individuals with type 2 diabetes mellitus (T2DM).MethodsA total of 183 T2DM patients were enrolled in this study. Comprehensive clinical data, including coagulation parameters and nerve conduction velocity, were collected and compared between patients with and without DPN. Subsequent correlation and regression analyses were conducted to explore the associations among APTT, HbA1c levels, and nerve conduction velocities. Moreover, mediation analyses were performed to evaluate the total, direct, and indirect effects of HbA1c on specific nerve conduction velocities, with APTT serving as a mediator.ResultsIn comparison to 101 patients without DPN, 82 patients with DPN exhibited significantly elevated levels of HbA1c and decreased levels of APTT. Notably, levels of APTT and HbA1c were correlated with conduction velocities of Tibial nerve motor fibers, as well as sensory fibers of the Ulnar nerve, Median nerve, and Sural nerve. Furthermore, both elevated HbA1c and decreased APTT were identified as risk factors for DPN in T2DM individuals. Mediation analysis showed that APTT mediated the indirect effect of HbA1c on the conduction velocities of sensory fibers in both the ulnar nerve and sural nerve (95% CI: -0.3448, -0.0135; -0.3523, -0.0180). APTT mediated the relationship between HbA1c and the conduction velocities of sensory fibers in the ulnar nerve or sural nerve by 34.66% or 22.03%, respectively.ConclusionsIn patients with T2DM, uncontrolled HbA1c and shorter APTT emerges as risk factors for DPN. Additionally, the effect of increased HbA1c upon DPN, especially for influenced conduction velocities of sensory fibers in both the ulnar nerve and sural nerve may partly medicated by decreased APTT. |
| format | Article |
| id | doaj-art-b5599ce96a424da6b1d63181e9d15798 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-b5599ce96a424da6b1d63181e9d157982025-01-23T05:10:32ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011610.3389/fendo.2025.15013231501323The role of activated partial thrombin time in mediating the impact of poorly glycemic control on diabetic peripheral neuropathy in patients with type 2 diabetes mellitusHui Zhang0Minghui Chen1Lijie Sun2Wenwen Zhu3Wenwen Zhu4Tong Niu5Huzaifa Fareeduddin Mohammmed Farooqui6Hongxiao Wang7Bing Song8Jumei Wang9Haoqiang Zhang10Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, ChinaDepartment of Endocrinology, Institute of Endocrine and Metabolic Diseases, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, ChinaDepartment of Endocrinology, Institute of Endocrine and Metabolic Diseases, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, ChinaDepartment of Endocrinology, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, ChinaAffiliated Zhongda Hospital of Southeast University, Nanjing, ChinaAffiliated Zhongda Hospital of Southeast University, Nanjing, ChinaAffiliated Zhongda Hospital of Southeast University, Nanjing, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, ChinaDepartment of Endocrinology, Institute of Endocrine and Metabolic Diseases, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, ChinaDepartment of Endocrinology, Institute of Endocrine and Metabolic Diseases, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, ChinaAimThis study aims to investigate the role of activated partial thrombin time (APTT) as a potential mediator in the relationship between suboptimal glycemic control and diabetic peripheral neuropathy (DPN) in individuals with type 2 diabetes mellitus (T2DM).MethodsA total of 183 T2DM patients were enrolled in this study. Comprehensive clinical data, including coagulation parameters and nerve conduction velocity, were collected and compared between patients with and without DPN. Subsequent correlation and regression analyses were conducted to explore the associations among APTT, HbA1c levels, and nerve conduction velocities. Moreover, mediation analyses were performed to evaluate the total, direct, and indirect effects of HbA1c on specific nerve conduction velocities, with APTT serving as a mediator.ResultsIn comparison to 101 patients without DPN, 82 patients with DPN exhibited significantly elevated levels of HbA1c and decreased levels of APTT. Notably, levels of APTT and HbA1c were correlated with conduction velocities of Tibial nerve motor fibers, as well as sensory fibers of the Ulnar nerve, Median nerve, and Sural nerve. Furthermore, both elevated HbA1c and decreased APTT were identified as risk factors for DPN in T2DM individuals. Mediation analysis showed that APTT mediated the indirect effect of HbA1c on the conduction velocities of sensory fibers in both the ulnar nerve and sural nerve (95% CI: -0.3448, -0.0135; -0.3523, -0.0180). APTT mediated the relationship between HbA1c and the conduction velocities of sensory fibers in the ulnar nerve or sural nerve by 34.66% or 22.03%, respectively.ConclusionsIn patients with T2DM, uncontrolled HbA1c and shorter APTT emerges as risk factors for DPN. Additionally, the effect of increased HbA1c upon DPN, especially for influenced conduction velocities of sensory fibers in both the ulnar nerve and sural nerve may partly medicated by decreased APTT.https://www.frontiersin.org/articles/10.3389/fendo.2025.1501323/fullactivated partial thrombin timediabetic peripheral neuropathytype 2 diabetes mellitushyperglycemianerve conduction velocity |
| spellingShingle | Hui Zhang Minghui Chen Lijie Sun Wenwen Zhu Wenwen Zhu Tong Niu Huzaifa Fareeduddin Mohammmed Farooqui Hongxiao Wang Bing Song Jumei Wang Haoqiang Zhang The role of activated partial thrombin time in mediating the impact of poorly glycemic control on diabetic peripheral neuropathy in patients with type 2 diabetes mellitus Frontiers in Endocrinology activated partial thrombin time diabetic peripheral neuropathy type 2 diabetes mellitus hyperglycemia nerve conduction velocity |
| title | The role of activated partial thrombin time in mediating the impact of poorly glycemic control on diabetic peripheral neuropathy in patients with type 2 diabetes mellitus |
| title_full | The role of activated partial thrombin time in mediating the impact of poorly glycemic control on diabetic peripheral neuropathy in patients with type 2 diabetes mellitus |
| title_fullStr | The role of activated partial thrombin time in mediating the impact of poorly glycemic control on diabetic peripheral neuropathy in patients with type 2 diabetes mellitus |
| title_full_unstemmed | The role of activated partial thrombin time in mediating the impact of poorly glycemic control on diabetic peripheral neuropathy in patients with type 2 diabetes mellitus |
| title_short | The role of activated partial thrombin time in mediating the impact of poorly glycemic control on diabetic peripheral neuropathy in patients with type 2 diabetes mellitus |
| title_sort | role of activated partial thrombin time in mediating the impact of poorly glycemic control on diabetic peripheral neuropathy in patients with type 2 diabetes mellitus |
| topic | activated partial thrombin time diabetic peripheral neuropathy type 2 diabetes mellitus hyperglycemia nerve conduction velocity |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1501323/full |
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