Low hemoglobin A1c levels in a patient with diabetic ketoacidosis: Fulminant type 1 diabetes mellitus
Fulminant type 1 diabetes mellitus (FT1DM) is a clinical condition that is characterized by remarkably rapid and complete pancreatic β-cell destruction, rapid onset of hyperglycemic symptoms followed by ketoacidosis. In most cases this process takes a few days. Although rare, there have been clinic...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hacettepe University Institute of Child Health
2018-04-01
|
| Series: | The Turkish Journal of Pediatrics |
| Subjects: | |
| Online Access: | https://turkjpediatr.org/article/view/841 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850042060529205248 |
|---|---|
| author | Melikşah Keskin Şenay Savaş-Erdeve Semra Çetinkaya Zehra Aycan |
| author_facet | Melikşah Keskin Şenay Savaş-Erdeve Semra Çetinkaya Zehra Aycan |
| author_sort | Melikşah Keskin |
| collection | DOAJ |
| description |
Fulminant type 1 diabetes mellitus (FT1DM) is a clinical condition that is characterized by remarkably rapid and complete pancreatic β-cell destruction, rapid onset of hyperglycemic symptoms followed by ketoacidosis. In most cases this process takes a few days. Although rare, there have been clinical manifestations with a prolonged progress that lasts longer than one week. This study focused on the case of a 35-monthold boy who was referred to our clinic with the diagnosis of diabetic ketoacidosis, and later had a modest elevation in hemoglobin A1c (HbA1c) levels (6.7 %) incompatible with his significantly elevated blood glucose levels. The autoantibodies against pancreatic β-cells were negative. On the basis of these above mentioned findings, our patient was then diagnosed with fulminant type 1 diabetes mellitus. If patients with diabetic ketoacidosis have no elevation in HbA1c levels, they should be assessed for possible clinical factors that can lead to lower detectable levels of HbA1c. Furthermore, FT1DM which is characterized by very rapid and potentially fatal progression should be considered as a differential diagnosis in these patients.
|
| format | Article |
| id | doaj-art-b5482ee98c8d47748e7be228c7139a3d |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2018-04-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-b5482ee98c8d47748e7be228c7139a3d2025-08-20T02:55:38ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212018-04-0160210.24953/turkjped.2018.02.015Low hemoglobin A1c levels in a patient with diabetic ketoacidosis: Fulminant type 1 diabetes mellitusMelikşah Keskin0Şenay Savaş-Erdeve1Semra Çetinkaya2Zehra Aycan3Pediatric Endocrinology Clinic, Dr. Sami Ulus Obstetrics and Gynecology and Pediatrics Training and Research Hospital, Ankara, Turkey.Pediatric Endocrinology Clinic, Dr. Sami Ulus Obstetrics and Gynecology and Pediatrics Training and Research Hospital, Ankara, Turkey.Pediatric Endocrinology Clinic, Dr. Sami Ulus Obstetrics and Gynecology and Pediatrics Training and Research Hospital, Ankara, Turkey.Pediatric Endocrinology Clinic, Dr. Sami Ulus Obstetrics and Gynecology and Pediatrics Training and Research Hospital, Ankara, Turkey. Fulminant type 1 diabetes mellitus (FT1DM) is a clinical condition that is characterized by remarkably rapid and complete pancreatic β-cell destruction, rapid onset of hyperglycemic symptoms followed by ketoacidosis. In most cases this process takes a few days. Although rare, there have been clinical manifestations with a prolonged progress that lasts longer than one week. This study focused on the case of a 35-monthold boy who was referred to our clinic with the diagnosis of diabetic ketoacidosis, and later had a modest elevation in hemoglobin A1c (HbA1c) levels (6.7 %) incompatible with his significantly elevated blood glucose levels. The autoantibodies against pancreatic β-cells were negative. On the basis of these above mentioned findings, our patient was then diagnosed with fulminant type 1 diabetes mellitus. If patients with diabetic ketoacidosis have no elevation in HbA1c levels, they should be assessed for possible clinical factors that can lead to lower detectable levels of HbA1c. Furthermore, FT1DM which is characterized by very rapid and potentially fatal progression should be considered as a differential diagnosis in these patients. https://turkjpediatr.org/article/view/841childhooddiabetic ketoacidosisinsulin dependent diabetes mellitus |
| spellingShingle | Melikşah Keskin Şenay Savaş-Erdeve Semra Çetinkaya Zehra Aycan Low hemoglobin A1c levels in a patient with diabetic ketoacidosis: Fulminant type 1 diabetes mellitus The Turkish Journal of Pediatrics childhood diabetic ketoacidosis insulin dependent diabetes mellitus |
| title | Low hemoglobin A1c levels in a patient with diabetic ketoacidosis: Fulminant type 1 diabetes mellitus |
| title_full | Low hemoglobin A1c levels in a patient with diabetic ketoacidosis: Fulminant type 1 diabetes mellitus |
| title_fullStr | Low hemoglobin A1c levels in a patient with diabetic ketoacidosis: Fulminant type 1 diabetes mellitus |
| title_full_unstemmed | Low hemoglobin A1c levels in a patient with diabetic ketoacidosis: Fulminant type 1 diabetes mellitus |
| title_short | Low hemoglobin A1c levels in a patient with diabetic ketoacidosis: Fulminant type 1 diabetes mellitus |
| title_sort | low hemoglobin a1c levels in a patient with diabetic ketoacidosis fulminant type 1 diabetes mellitus |
| topic | childhood diabetic ketoacidosis insulin dependent diabetes mellitus |
| url | https://turkjpediatr.org/article/view/841 |
| work_keys_str_mv | AT meliksahkeskin lowhemoglobina1clevelsinapatientwithdiabeticketoacidosisfulminanttype1diabetesmellitus AT senaysavaserdeve lowhemoglobina1clevelsinapatientwithdiabeticketoacidosisfulminanttype1diabetesmellitus AT semracetinkaya lowhemoglobina1clevelsinapatientwithdiabeticketoacidosisfulminanttype1diabetesmellitus AT zehraaycan lowhemoglobina1clevelsinapatientwithdiabeticketoacidosisfulminanttype1diabetesmellitus |