Advances in bioinformatics and multi-omics integration: transforming viral infectious disease research in veterinary medicine
Abstract The world is changing due to factors like bioterrorism, massive environmental changes, globalization of trade and commerce, growing urbanization, changing climate, and pollution. Numerous diseases have emerged because of these factors, especially in companion and food-producing animals. Num...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Virology Journal |
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| Online Access: | https://doi.org/10.1186/s12985-025-02640-x |
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| author | Alyaa Elrashedy Walid Mousa Mohamed Nayel Akram Salama Ahmed Zaghawa Ahmed Elsify Mohamed E. Hasan |
| author_facet | Alyaa Elrashedy Walid Mousa Mohamed Nayel Akram Salama Ahmed Zaghawa Ahmed Elsify Mohamed E. Hasan |
| author_sort | Alyaa Elrashedy |
| collection | DOAJ |
| description | Abstract The world is changing due to factors like bioterrorism, massive environmental changes, globalization of trade and commerce, growing urbanization, changing climate, and pollution. Numerous diseases have emerged because of these factors, especially in companion and food-producing animals. Numerous pathogens have established themselves in naïve populations, harming reproduction, productivity, and health. Bioinformatics is considered a valuable tool in infectious disease research, as it provides a comprehensive overview of the identification of pathogens, their genetic makeup, and their evolutionary relationship. Therefore, there is an urgent need for a novel bioinformatics approach to help decipher and model viral epidemiology and informatics on domestic animals and livestock. With significant advancements in bioinformatics and NGS, researchers can now identify contigs, which are contiguous sequences of DNA that are assembled from overlapping fragments, assemble a complete genome, perform phylogenetic analysis to diagnose, investigate the risk of viral diseases in animals, handle and share large biological datasets across various species. Additionally, multi-omics data integration further deepens our understanding of homology, divergence, mutations, and evolutionary relationships, providing a comprehensive perspective on the molecular mechanisms driving animal pathogens infections. This review aims to reveal the importance of utilizing the multidisciplinary areas of bioinformatics, genomics, proteomics, transcriptomics, metabolomics, and metagenomics and their roles in studying viral infectious diseases in veterinary medicine that will eventually improve the health of animals. |
| format | Article |
| id | doaj-art-b5451b5a8fc749cd887408db7ba54bfd |
| institution | Kabale University |
| issn | 1743-422X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj-art-b5451b5a8fc749cd887408db7ba54bfd2025-02-02T12:08:38ZengBMCVirology Journal1743-422X2025-01-0122111710.1186/s12985-025-02640-xAdvances in bioinformatics and multi-omics integration: transforming viral infectious disease research in veterinary medicineAlyaa Elrashedy0Walid Mousa1Mohamed Nayel2Akram Salama3Ahmed Zaghawa4Ahmed Elsify5Mohamed E. Hasan6Department of Animal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, University of Sadat CityDepartment of Animal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, University of Sadat CityDepartment of Animal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, University of Sadat CityDepartment of Animal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, University of Sadat CityDepartment of Animal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, University of Sadat CityDepartment of Animal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, University of Sadat CityBioinformatics Department, Genetic Engineering and Biotechnology Research Institute, University of Sadat CityAbstract The world is changing due to factors like bioterrorism, massive environmental changes, globalization of trade and commerce, growing urbanization, changing climate, and pollution. Numerous diseases have emerged because of these factors, especially in companion and food-producing animals. Numerous pathogens have established themselves in naïve populations, harming reproduction, productivity, and health. Bioinformatics is considered a valuable tool in infectious disease research, as it provides a comprehensive overview of the identification of pathogens, their genetic makeup, and their evolutionary relationship. Therefore, there is an urgent need for a novel bioinformatics approach to help decipher and model viral epidemiology and informatics on domestic animals and livestock. With significant advancements in bioinformatics and NGS, researchers can now identify contigs, which are contiguous sequences of DNA that are assembled from overlapping fragments, assemble a complete genome, perform phylogenetic analysis to diagnose, investigate the risk of viral diseases in animals, handle and share large biological datasets across various species. Additionally, multi-omics data integration further deepens our understanding of homology, divergence, mutations, and evolutionary relationships, providing a comprehensive perspective on the molecular mechanisms driving animal pathogens infections. This review aims to reveal the importance of utilizing the multidisciplinary areas of bioinformatics, genomics, proteomics, transcriptomics, metabolomics, and metagenomics and their roles in studying viral infectious diseases in veterinary medicine that will eventually improve the health of animals.https://doi.org/10.1186/s12985-025-02640-xGenomicsProteomicsNGSTranscriptomicsMetabolomicsMetagenomics |
| spellingShingle | Alyaa Elrashedy Walid Mousa Mohamed Nayel Akram Salama Ahmed Zaghawa Ahmed Elsify Mohamed E. Hasan Advances in bioinformatics and multi-omics integration: transforming viral infectious disease research in veterinary medicine Virology Journal Genomics Proteomics NGS Transcriptomics Metabolomics Metagenomics |
| title | Advances in bioinformatics and multi-omics integration: transforming viral infectious disease research in veterinary medicine |
| title_full | Advances in bioinformatics and multi-omics integration: transforming viral infectious disease research in veterinary medicine |
| title_fullStr | Advances in bioinformatics and multi-omics integration: transforming viral infectious disease research in veterinary medicine |
| title_full_unstemmed | Advances in bioinformatics and multi-omics integration: transforming viral infectious disease research in veterinary medicine |
| title_short | Advances in bioinformatics and multi-omics integration: transforming viral infectious disease research in veterinary medicine |
| title_sort | advances in bioinformatics and multi omics integration transforming viral infectious disease research in veterinary medicine |
| topic | Genomics Proteomics NGS Transcriptomics Metabolomics Metagenomics |
| url | https://doi.org/10.1186/s12985-025-02640-x |
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