Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans.

Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans.

For cells the passage from life to death can involve a regulated, programmed transition. In contrast to cell death, the mechanisms of systemic collapse underlying organismal death remain poorly understood. Here we present evidence of a cascade of cell death involving the calpain-cathepsin necrosis p...

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Main Authors: Cassandra Coburn, Erik Allman, Parag Mahanti, Alexandre Benedetto, Filipe Cabreiro, Zachary Pincus, Filip Matthijssens, Caroline Araiz, Abraham Mandel, Manolis Vlachos, Sally-Anne Edwards, Grahame Fischer, Alexander Davidson, Rosina E Pryor, Ailsa Stevens, Frank J Slack, Nektarios Tavernarakis, Bart P Braeckman, Frank C Schroeder, Keith Nehrke, David Gems
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-07-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.1001613
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https://doi.org/10.1371/journal.pbio.1001613

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