Serum Potassium and Glucose Regulation in the ADDITION-Leicester Screening Study
Introduction. Previous observational studies have shown conflicting results between plasma K+ concentrations and risk of type 2 diabetes. To help clarify the evidence we aimed to determine whether an association existed between serum K+ and glucose regulation within a UK multiethnic population. Meth...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/923749 |
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| author | Patrice Carter Danielle H. Bodicoat Lauren M. Quinn Francesco Zaccardi David R. Webb Kamlesh Khunti Melanie J. Davies |
| author_facet | Patrice Carter Danielle H. Bodicoat Lauren M. Quinn Francesco Zaccardi David R. Webb Kamlesh Khunti Melanie J. Davies |
| author_sort | Patrice Carter |
| collection | DOAJ |
| description | Introduction. Previous observational studies have shown conflicting results between plasma K+ concentrations and risk of type 2 diabetes. To help clarify the evidence we aimed to determine whether an association existed between serum K+ and glucose regulation within a UK multiethnic population. Methods. Participants were recruited as part of the ADDITION Leicester study, a population based screening study. Individuals from primary care between the age of 40 and 75 years if White European or 25 and 75 years if South Asian or Afro Caribbean were recruited. Tests for associations between baseline characteristics and K+ quartiles were conducted using linear regression models. Results. Data showed individuals in the lowest K+ quartile had significantly greater 2-hour glucose levels (0.53 mmol/L, 95% CI: 0.36 to 0.70, P≤0.001) than those in the highest K+ quartile. This estimation did not change with adjustment for potential confounders. Conversely, participants in the lowest K+ quartile had a 0.14% lower HbA1c (95% CI −0.19 to −0.10: P≤0.001) compared to those in the highest K+ quartile. Conclusion. This cross-sectional analysis demonstrated that lower K+ was associated with greater 2 hr glucose. The data supports the possibility that K+ may influence glucose regulation and further research is warranted. |
| format | Article |
| id | doaj-art-b52ad4cffb92431783d31e78338d0564 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-b52ad4cffb92431783d31e78338d05642025-02-03T06:01:21ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/923749923749Serum Potassium and Glucose Regulation in the ADDITION-Leicester Screening StudyPatrice Carter0Danielle H. Bodicoat1Lauren M. Quinn2Francesco Zaccardi3David R. Webb4Kamlesh Khunti5Melanie J. Davies6University of Leicester, Diabetes Research Centre, Leicester Diabetes Centre, Leicester General Hospital, Leicester LE5 4PW, UKUniversity of Leicester, Diabetes Research Centre, Leicester Diabetes Centre, Leicester General Hospital, Leicester LE5 4PW, UKNuffield Science Bursary, University of Birmingham, Birmingham B15 2TT, UKUniversity of Leicester, Diabetes Research Centre, Leicester Diabetes Centre, Leicester General Hospital, Leicester LE5 4PW, UKUniversity of Leicester, Diabetes Research Centre, Leicester Diabetes Centre, Leicester General Hospital, Leicester LE5 4PW, UKUniversity of Leicester, Diabetes Research Centre, Leicester Diabetes Centre, Leicester General Hospital, Leicester LE5 4PW, UKUniversity of Leicester, Diabetes Research Centre, Leicester Diabetes Centre, Leicester General Hospital, Leicester LE5 4PW, UKIntroduction. Previous observational studies have shown conflicting results between plasma K+ concentrations and risk of type 2 diabetes. To help clarify the evidence we aimed to determine whether an association existed between serum K+ and glucose regulation within a UK multiethnic population. Methods. Participants were recruited as part of the ADDITION Leicester study, a population based screening study. Individuals from primary care between the age of 40 and 75 years if White European or 25 and 75 years if South Asian or Afro Caribbean were recruited. Tests for associations between baseline characteristics and K+ quartiles were conducted using linear regression models. Results. Data showed individuals in the lowest K+ quartile had significantly greater 2-hour glucose levels (0.53 mmol/L, 95% CI: 0.36 to 0.70, P≤0.001) than those in the highest K+ quartile. This estimation did not change with adjustment for potential confounders. Conversely, participants in the lowest K+ quartile had a 0.14% lower HbA1c (95% CI −0.19 to −0.10: P≤0.001) compared to those in the highest K+ quartile. Conclusion. This cross-sectional analysis demonstrated that lower K+ was associated with greater 2 hr glucose. The data supports the possibility that K+ may influence glucose regulation and further research is warranted.http://dx.doi.org/10.1155/2015/923749 |
| spellingShingle | Patrice Carter Danielle H. Bodicoat Lauren M. Quinn Francesco Zaccardi David R. Webb Kamlesh Khunti Melanie J. Davies Serum Potassium and Glucose Regulation in the ADDITION-Leicester Screening Study Journal of Diabetes Research |
| title | Serum Potassium and Glucose Regulation in the ADDITION-Leicester Screening Study |
| title_full | Serum Potassium and Glucose Regulation in the ADDITION-Leicester Screening Study |
| title_fullStr | Serum Potassium and Glucose Regulation in the ADDITION-Leicester Screening Study |
| title_full_unstemmed | Serum Potassium and Glucose Regulation in the ADDITION-Leicester Screening Study |
| title_short | Serum Potassium and Glucose Regulation in the ADDITION-Leicester Screening Study |
| title_sort | serum potassium and glucose regulation in the addition leicester screening study |
| url | http://dx.doi.org/10.1155/2015/923749 |
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