Comparing Sensitivity and Specificity of Addenbrooke’s Cognitive Examination-I, III and Mini-Addenbrooke’s Cognitive Examination in Parkinson’s Disease
Background. Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterized by numerous motor and nonmotor symptoms. Neurocognitive disorders (NCD) are one of the most troublesome problems and their diagnosis is often challenging. Methods. We compared the sensitivity and...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2018/5932028 |
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| author | Tivadar Lucza Zsuzsanna Ascherman Márton Kovács Attila Makkos Márk Harmat Annamária Juhász József Janszky Sámuel Komoly Norbert Kovács Krisztina Dorn Kázmér Karádi |
| author_facet | Tivadar Lucza Zsuzsanna Ascherman Márton Kovács Attila Makkos Márk Harmat Annamária Juhász József Janszky Sámuel Komoly Norbert Kovács Krisztina Dorn Kázmér Karádi |
| author_sort | Tivadar Lucza |
| collection | DOAJ |
| description | Background. Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterized by numerous motor and nonmotor symptoms. Neurocognitive disorders (NCD) are one of the most troublesome problems and their diagnosis is often challenging. Methods. We compared the sensitivity and specificity of several versions of Addenbrooke Cognitive Examination (ACE, ACE-III, and Mini-ACE) on 552 subjects with PD. Normal cognition, mild and major NCD were judged in accordance with the respective criteria of the Diagnostic and Statistical Manual of Mental Disorders 5th edition. Subsequently, we applied the receiver operation characteristic (ROC) analysis in comparison of different education levels. Results. For subjects with education level 0–8 and 9–12 years, the ACE-III had the best discriminating capabilities for mild NCD (cut-off scores: 83.5 and 85.5 points, respectively), while Mini-ACE was the best for subjects having education > 12 years (cut-off score: 25.5 points). For detecting major NCD, ACE-III had the best diagnostic accuracy in all levels of education (cut-off scores: 70.5, 77.5, and 78.5 points for subjects having education level 0–8, 9–12, and >12 years, respectively). Conclusion. ACE-III and its nested version, the Mini-ACE, had the best screening abilities for detecting mild and major NCD in PD. |
| format | Article |
| id | doaj-art-b51fe26d5e3c4122b6b49b331c8d56df |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-b51fe26d5e3c4122b6b49b331c8d56df2025-02-03T01:00:17ZengWileyBehavioural Neurology0953-41801875-85842018-01-01201810.1155/2018/59320285932028Comparing Sensitivity and Specificity of Addenbrooke’s Cognitive Examination-I, III and Mini-Addenbrooke’s Cognitive Examination in Parkinson’s DiseaseTivadar Lucza0Zsuzsanna Ascherman1Márton Kovács2Attila Makkos3Márk Harmat4Annamária Juhász5József Janszky6Sámuel Komoly7Norbert Kovács8Krisztina Dorn9Kázmér Karádi10Institute of Behavioral Sciences, University of Pécs, Pécs, HungaryDepartment of Neurology, University of Pécs, Pécs, HungaryDepartment of Neurology, University of Pécs, Pécs, HungaryDepartment of Neurology, University of Pécs, Pécs, HungaryDepartment of Neurology, University of Pécs, Pécs, HungaryDepartment of Neurology, University of Pécs, Pécs, HungaryDepartment of Neurology, University of Pécs, Pécs, HungaryDepartment of Neurology, University of Pécs, Pécs, HungaryDepartment of Neurology, University of Pécs, Pécs, HungaryPediatric Clinic, University of Pécs, Pécs, HungaryInstitute of Behavioral Sciences, University of Pécs, Pécs, HungaryBackground. Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterized by numerous motor and nonmotor symptoms. Neurocognitive disorders (NCD) are one of the most troublesome problems and their diagnosis is often challenging. Methods. We compared the sensitivity and specificity of several versions of Addenbrooke Cognitive Examination (ACE, ACE-III, and Mini-ACE) on 552 subjects with PD. Normal cognition, mild and major NCD were judged in accordance with the respective criteria of the Diagnostic and Statistical Manual of Mental Disorders 5th edition. Subsequently, we applied the receiver operation characteristic (ROC) analysis in comparison of different education levels. Results. For subjects with education level 0–8 and 9–12 years, the ACE-III had the best discriminating capabilities for mild NCD (cut-off scores: 83.5 and 85.5 points, respectively), while Mini-ACE was the best for subjects having education > 12 years (cut-off score: 25.5 points). For detecting major NCD, ACE-III had the best diagnostic accuracy in all levels of education (cut-off scores: 70.5, 77.5, and 78.5 points for subjects having education level 0–8, 9–12, and >12 years, respectively). Conclusion. ACE-III and its nested version, the Mini-ACE, had the best screening abilities for detecting mild and major NCD in PD.http://dx.doi.org/10.1155/2018/5932028 |
| spellingShingle | Tivadar Lucza Zsuzsanna Ascherman Márton Kovács Attila Makkos Márk Harmat Annamária Juhász József Janszky Sámuel Komoly Norbert Kovács Krisztina Dorn Kázmér Karádi Comparing Sensitivity and Specificity of Addenbrooke’s Cognitive Examination-I, III and Mini-Addenbrooke’s Cognitive Examination in Parkinson’s Disease Behavioural Neurology |
| title | Comparing Sensitivity and Specificity of Addenbrooke’s Cognitive Examination-I, III and Mini-Addenbrooke’s Cognitive Examination in Parkinson’s Disease |
| title_full | Comparing Sensitivity and Specificity of Addenbrooke’s Cognitive Examination-I, III and Mini-Addenbrooke’s Cognitive Examination in Parkinson’s Disease |
| title_fullStr | Comparing Sensitivity and Specificity of Addenbrooke’s Cognitive Examination-I, III and Mini-Addenbrooke’s Cognitive Examination in Parkinson’s Disease |
| title_full_unstemmed | Comparing Sensitivity and Specificity of Addenbrooke’s Cognitive Examination-I, III and Mini-Addenbrooke’s Cognitive Examination in Parkinson’s Disease |
| title_short | Comparing Sensitivity and Specificity of Addenbrooke’s Cognitive Examination-I, III and Mini-Addenbrooke’s Cognitive Examination in Parkinson’s Disease |
| title_sort | comparing sensitivity and specificity of addenbrooke s cognitive examination i iii and mini addenbrooke s cognitive examination in parkinson s disease |
| url | http://dx.doi.org/10.1155/2018/5932028 |
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