Peripheral monocyte transcriptional signatures of inflammation and oxidative stress in Parkinson’s disease

Peripheral monocyte transcriptional signatures of inflammation and oxidative stress in Parkinson’s disease

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuron loss in the substantia nigra, which is accompanied by immune dysfunction and chronic inflammation. Peripheral monocytes, key players in systemic inflammation, cross the blood-brain barrier and a...

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Bibliographic Details
Main Authors: Aaron D. Thome, Jinghong Wang, Farah Atassi, Jason R. Thonhoff, Alireza Faridar, Weihua Zhao, David R. Beers, Eugene C. Lai, Stanley H. Appel
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
Parkinson’s disease
monocytes
inflammation
neuroinflammation
oxidative stress
peripheral biomarkers
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1571074/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1571074/full

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