The LncRNA PRNCR1 rs13252298 GG genotype is correlated with reducing susceptibility to recurrent spontaneous miscarriage in a southern Chinese population
Background: LncRNAs play diverse roles and participate in various biological processes within the human body. It has been frequently reported that they are involved in the occurrence and development of recurrent spontaneous miscarriage. PRNCR1 , a crucial player in several types of cancers, may also...
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SAGE Publishing
2024-11-01
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| Series: | SAGE Open Medicine |
| Online Access: | https://doi.org/10.1177/20503121241303075 |
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| author | Hanran Mai Junyi Ke Xilian Luo Zilin Zheng Jieyi Luo Chenlu Wang Yueling Lin Menghua He Yanxia Qu Yufen Xu Lanyan Fu Lei Pi Huazhong Zhou Xiaoqiong Gu Di Che Liandong Zuo |
| author_facet | Hanran Mai Junyi Ke Xilian Luo Zilin Zheng Jieyi Luo Chenlu Wang Yueling Lin Menghua He Yanxia Qu Yufen Xu Lanyan Fu Lei Pi Huazhong Zhou Xiaoqiong Gu Di Che Liandong Zuo |
| author_sort | Hanran Mai |
| collection | DOAJ |
| description | Background: LncRNAs play diverse roles and participate in various biological processes within the human body. It has been frequently reported that they are involved in the occurrence and development of recurrent spontaneous miscarriage. PRNCR1 , a crucial player in several types of cancers, may also have implications for recurrent spontaneous miscarriage risk. However, the correlation between PRNCR1 rs13252298 A > G polymorphism and this risk remains unclear. In summary, we conducted the following experiments to investigate the association between the PRNCR1 polymorphic site rs13252298 and susceptibility to recurrent spontaneous miscarriage. Method: Our research included 695 healthy controls and 413 patients with recurrent spontaneous miscarriage from southern China. Genotyping was performed using the TaqMan method. Result: Our findings revealed that there is a relationship between PRNCR1 rs13252298 A > G polymorphism and lower susceptibility to recurrent spontaneous miscarriage (AG and AA: adjusted OR = 0.794, 95% CI = 0.527–1.196, p = 0.2696; GG and AA: adjusted OR = 0.705, 95% CI = 0.542–0.917, p = 0.0092; dominant model: adjusted OR = 0.722, 95% CI = 0.563–0.926, p = 0.0104; recessive model: adjusted OR = 0.949, 95% CI = 0.644–1.398, p = 0.7912). Conclusion: The results of our study demonstrate that the PRNCR1 rs13252298 A > G allele may contribute to a decreased risk of recurrent spontaneous miscarriage. The rs13252298 polymorphism could potentially serve as a biomarker for detecting recurrent spontaneous miscarriage risk and aiding prevention efforts. |
| format | Article |
| id | doaj-art-b51cfc506cab4a988ebcd18fe2d201cf |
| institution | OA Journals |
| issn | 2050-3121 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medicine |
| spelling | doaj-art-b51cfc506cab4a988ebcd18fe2d201cf2025-08-20T02:07:13ZengSAGE PublishingSAGE Open Medicine2050-31212024-11-011210.1177/20503121241303075The LncRNA PRNCR1 rs13252298 GG genotype is correlated with reducing susceptibility to recurrent spontaneous miscarriage in a southern Chinese populationHanran Mai0Junyi Ke1Xilian Luo2Zilin Zheng3Jieyi Luo4Chenlu Wang5Yueling Lin6Menghua He7Yanxia Qu8Yufen Xu9Lanyan Fu10Lei Pi11Huazhong Zhou12Xiaoqiong Gu13Di Che14Liandong Zuo15Department of Andrology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaDepartment of Clinical Biological Resource Bank, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangdong, Guangzhou, ChinaDepartment of Clinical Biological Resource Bank, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangdong, Guangzhou, ChinaDepartment of Clinical Biological Resource Bank, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangdong, Guangzhou, ChinaDepartment of Gynecology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangdong, Guangzhou, ChinaDepartment of Clinical Biological Resource Bank, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangdong, Guangzhou, ChinaDepartment of Clinical Biological Resource Bank, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangdong, Guangzhou, ChinaDepartment of Clinical Lab, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, ChinaDepartment of Gynecology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangdong, Guangzhou, ChinaDepartment of Clinical Biological Resource Bank, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangdong, Guangzhou, ChinaDepartment of Clinical Biological Resource Bank, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangdong, Guangzhou, ChinaDepartment of Clinical Biological Resource Bank, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangdong, Guangzhou, ChinaDepartment of Clinical Biological Resource Bank, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangdong, Guangzhou, ChinaDepartment of Clinical Biological Resource Bank, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangdong, Guangzhou, ChinaDepartment of Clinical Biological Resource Bank, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangdong, Guangzhou, ChinaDepartment of Andrology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaBackground: LncRNAs play diverse roles and participate in various biological processes within the human body. It has been frequently reported that they are involved in the occurrence and development of recurrent spontaneous miscarriage. PRNCR1 , a crucial player in several types of cancers, may also have implications for recurrent spontaneous miscarriage risk. However, the correlation between PRNCR1 rs13252298 A > G polymorphism and this risk remains unclear. In summary, we conducted the following experiments to investigate the association between the PRNCR1 polymorphic site rs13252298 and susceptibility to recurrent spontaneous miscarriage. Method: Our research included 695 healthy controls and 413 patients with recurrent spontaneous miscarriage from southern China. Genotyping was performed using the TaqMan method. Result: Our findings revealed that there is a relationship between PRNCR1 rs13252298 A > G polymorphism and lower susceptibility to recurrent spontaneous miscarriage (AG and AA: adjusted OR = 0.794, 95% CI = 0.527–1.196, p = 0.2696; GG and AA: adjusted OR = 0.705, 95% CI = 0.542–0.917, p = 0.0092; dominant model: adjusted OR = 0.722, 95% CI = 0.563–0.926, p = 0.0104; recessive model: adjusted OR = 0.949, 95% CI = 0.644–1.398, p = 0.7912). Conclusion: The results of our study demonstrate that the PRNCR1 rs13252298 A > G allele may contribute to a decreased risk of recurrent spontaneous miscarriage. The rs13252298 polymorphism could potentially serve as a biomarker for detecting recurrent spontaneous miscarriage risk and aiding prevention efforts.https://doi.org/10.1177/20503121241303075 |
| spellingShingle | Hanran Mai Junyi Ke Xilian Luo Zilin Zheng Jieyi Luo Chenlu Wang Yueling Lin Menghua He Yanxia Qu Yufen Xu Lanyan Fu Lei Pi Huazhong Zhou Xiaoqiong Gu Di Che Liandong Zuo The LncRNA PRNCR1 rs13252298 GG genotype is correlated with reducing susceptibility to recurrent spontaneous miscarriage in a southern Chinese population SAGE Open Medicine |
| title | The LncRNA PRNCR1 rs13252298 GG genotype is correlated with reducing susceptibility to recurrent spontaneous miscarriage in a southern Chinese population |
| title_full | The LncRNA PRNCR1 rs13252298 GG genotype is correlated with reducing susceptibility to recurrent spontaneous miscarriage in a southern Chinese population |
| title_fullStr | The LncRNA PRNCR1 rs13252298 GG genotype is correlated with reducing susceptibility to recurrent spontaneous miscarriage in a southern Chinese population |
| title_full_unstemmed | The LncRNA PRNCR1 rs13252298 GG genotype is correlated with reducing susceptibility to recurrent spontaneous miscarriage in a southern Chinese population |
| title_short | The LncRNA PRNCR1 rs13252298 GG genotype is correlated with reducing susceptibility to recurrent spontaneous miscarriage in a southern Chinese population |
| title_sort | lncrna prncr1 rs13252298 gg genotype is correlated with reducing susceptibility to recurrent spontaneous miscarriage in a southern chinese population |
| url | https://doi.org/10.1177/20503121241303075 |
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