Sex-Specific Association between Serum Uric Acid and Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Patients
Across-sectional study was performed in 541 type 2 diabetic patients to determine the relationship between serum uric acid (SUA) and NAFLD in type 2 diabetic patients. Clinical parameters including SUA were determined and NAFLD was diagnosed by ultrasonography. SUA was significantly higher in type 2...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/3805372 |
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| author | Nengguang Fan Lijuan Zhang Zhenhua Xia Liang Peng Yufan Wang Yongde Peng |
| author_facet | Nengguang Fan Lijuan Zhang Zhenhua Xia Liang Peng Yufan Wang Yongde Peng |
| author_sort | Nengguang Fan |
| collection | DOAJ |
| description | Across-sectional study was performed in 541 type 2 diabetic patients to determine the relationship between serum uric acid (SUA) and NAFLD in type 2 diabetic patients. Clinical parameters including SUA were determined and NAFLD was diagnosed by ultrasonography. SUA was significantly higher in type 2 diabetic subjects with NAFLD than in those without NAFLD in men, but not in women. Furthermore, the prevalence rate of NAFLD increased progressively across the sex-specific SUA tertiles only in men (37.9%, 58.6%, and 72.6%, resp., P for trend < 0.001). After adjusting for confounding factors, the odd ratios (95% CI) for NAFLD were 1 (reference), 2.93 (95%CI 1.25–6.88), and 3.93 (95% CI 1.55–9.98), respectively, across the tertiles of SUA in men. Contrastingly, SUA levels in women were not independently associated with the risk of NAFLD. Our data suggests that SUA is specifically associated with NAFLD in male type 2 diabetic subjects, independent of insulin resistance and other metabolic factors. |
| format | Article |
| id | doaj-art-b51a69f1a5fd417e8d09bf6b02433f23 |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-b51a69f1a5fd417e8d09bf6b02433f232025-08-20T02:23:31ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/38053723805372Sex-Specific Association between Serum Uric Acid and Nonalcoholic Fatty Liver Disease in Type 2 Diabetic PatientsNengguang Fan0Lijuan Zhang1Zhenhua Xia2Liang Peng3Yufan Wang4Yongde Peng5Department of Endocrinology and Metabolism, Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shanghai 200080, ChinaDepartment of Endocrinology, Shanghai Songjiang Center Hospital, Shanghai 201600, ChinaDepartment of Endocrinology, Shanghai Songjiang Center Hospital, Shanghai 201600, ChinaDepartment of Laboratory Medicine, Shanghai Songjiang Center Hospital, Shanghai 201600, ChinaDepartment of Endocrinology and Metabolism, Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shanghai 200080, ChinaDepartment of Endocrinology and Metabolism, Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shanghai 200080, ChinaAcross-sectional study was performed in 541 type 2 diabetic patients to determine the relationship between serum uric acid (SUA) and NAFLD in type 2 diabetic patients. Clinical parameters including SUA were determined and NAFLD was diagnosed by ultrasonography. SUA was significantly higher in type 2 diabetic subjects with NAFLD than in those without NAFLD in men, but not in women. Furthermore, the prevalence rate of NAFLD increased progressively across the sex-specific SUA tertiles only in men (37.9%, 58.6%, and 72.6%, resp., P for trend < 0.001). After adjusting for confounding factors, the odd ratios (95% CI) for NAFLD were 1 (reference), 2.93 (95%CI 1.25–6.88), and 3.93 (95% CI 1.55–9.98), respectively, across the tertiles of SUA in men. Contrastingly, SUA levels in women were not independently associated with the risk of NAFLD. Our data suggests that SUA is specifically associated with NAFLD in male type 2 diabetic subjects, independent of insulin resistance and other metabolic factors.http://dx.doi.org/10.1155/2016/3805372 |
| spellingShingle | Nengguang Fan Lijuan Zhang Zhenhua Xia Liang Peng Yufan Wang Yongde Peng Sex-Specific Association between Serum Uric Acid and Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Patients Journal of Diabetes Research |
| title | Sex-Specific Association between Serum Uric Acid and Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Patients |
| title_full | Sex-Specific Association between Serum Uric Acid and Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Patients |
| title_fullStr | Sex-Specific Association between Serum Uric Acid and Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Patients |
| title_full_unstemmed | Sex-Specific Association between Serum Uric Acid and Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Patients |
| title_short | Sex-Specific Association between Serum Uric Acid and Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Patients |
| title_sort | sex specific association between serum uric acid and nonalcoholic fatty liver disease in type 2 diabetic patients |
| url | http://dx.doi.org/10.1155/2016/3805372 |
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