Complete Resolution of Pseudomalignant Erosion in a Reflux Gastroesophageal Polyp with Proton Pump Inhibitor
Pseudomalignant erosion is a diagnostic pitfall for pathologists in the differential diagnosis of malignant neoplasms. Here, we present a challenging case of a biopsy specimen from the eroded head of a polyp at the esophagogastric junction. A malignant neoplasm could not be ruled out due to the pres...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2015/657059 |
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| author | Takahiko Nakajima Haruo Yagi Hayato Baba Takashi Minamisaka Shigeharu Miwa Shinichi Hayashi Takeshi Nishida Hideki Hatta Koichi Tsuneyama Johji Imura |
| author_facet | Takahiko Nakajima Haruo Yagi Hayato Baba Takashi Minamisaka Shigeharu Miwa Shinichi Hayashi Takeshi Nishida Hideki Hatta Koichi Tsuneyama Johji Imura |
| author_sort | Takahiko Nakajima |
| collection | DOAJ |
| description | Pseudomalignant erosion is a diagnostic pitfall for pathologists in the differential diagnosis of malignant neoplasms. Here, we present a challenging case of a biopsy specimen from the eroded head of a polyp at the esophagogastric junction. A malignant neoplasm could not be ruled out due to the presence of bizarre stromal cells. A second biopsy performed after the administration of a proton pump inhibitor (PPI) for 4 weeks revealed endoscopic resolution of the polyp along with the complete histological resolution of the bizarre stromal cells and led to the diagnosis of pseudomalignant erosion in a reflux gastroesophageal polyp. In conclusion, histological and endoscopic response to PPI therapy is an important clue for the correct diagnosis of reflux gastroesophageal polyps with pseudomalignant erosion. |
| format | Article |
| id | doaj-art-b518e178a2a24098b5d9d1c08d3b9d74 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-b518e178a2a24098b5d9d1c08d3b9d742025-02-03T01:30:40ZengWileyCase Reports in Pathology2090-67812090-679X2015-01-01201510.1155/2015/657059657059Complete Resolution of Pseudomalignant Erosion in a Reflux Gastroesophageal Polyp with Proton Pump InhibitorTakahiko Nakajima0Haruo Yagi1Hayato Baba2Takashi Minamisaka3Shigeharu Miwa4Shinichi Hayashi5Takeshi Nishida6Hideki Hatta7Koichi Tsuneyama8Johji Imura9Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanDepartment of Surgery, Kouseiren Namerikawa Hospital, 119 Tokiwa-cho, Namerikawa 936-8585, JapanDepartment of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanDepartment of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanDepartment of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanDepartment of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanDepartment of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanDepartment of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanDepartment of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanDepartment of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanPseudomalignant erosion is a diagnostic pitfall for pathologists in the differential diagnosis of malignant neoplasms. Here, we present a challenging case of a biopsy specimen from the eroded head of a polyp at the esophagogastric junction. A malignant neoplasm could not be ruled out due to the presence of bizarre stromal cells. A second biopsy performed after the administration of a proton pump inhibitor (PPI) for 4 weeks revealed endoscopic resolution of the polyp along with the complete histological resolution of the bizarre stromal cells and led to the diagnosis of pseudomalignant erosion in a reflux gastroesophageal polyp. In conclusion, histological and endoscopic response to PPI therapy is an important clue for the correct diagnosis of reflux gastroesophageal polyps with pseudomalignant erosion.http://dx.doi.org/10.1155/2015/657059 |
| spellingShingle | Takahiko Nakajima Haruo Yagi Hayato Baba Takashi Minamisaka Shigeharu Miwa Shinichi Hayashi Takeshi Nishida Hideki Hatta Koichi Tsuneyama Johji Imura Complete Resolution of Pseudomalignant Erosion in a Reflux Gastroesophageal Polyp with Proton Pump Inhibitor Case Reports in Pathology |
| title | Complete Resolution of Pseudomalignant Erosion in a Reflux Gastroesophageal Polyp with Proton Pump Inhibitor |
| title_full | Complete Resolution of Pseudomalignant Erosion in a Reflux Gastroesophageal Polyp with Proton Pump Inhibitor |
| title_fullStr | Complete Resolution of Pseudomalignant Erosion in a Reflux Gastroesophageal Polyp with Proton Pump Inhibitor |
| title_full_unstemmed | Complete Resolution of Pseudomalignant Erosion in a Reflux Gastroesophageal Polyp with Proton Pump Inhibitor |
| title_short | Complete Resolution of Pseudomalignant Erosion in a Reflux Gastroesophageal Polyp with Proton Pump Inhibitor |
| title_sort | complete resolution of pseudomalignant erosion in a reflux gastroesophageal polyp with proton pump inhibitor |
| url | http://dx.doi.org/10.1155/2015/657059 |
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