Powering the Immune System: Mitochondria in Immune Function and Deficiency
Mitochondria are critical subcellular organelles that are required for several metabolic processes, including oxidative phosphorylation, as well as signaling and tissue-specific processes. Current understanding of the role of mitochondria in both the innate and adaptive immune systems is expanding....
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/164309 |
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| _version_ | 1832556406356574208 |
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| author | Melissa A. Walker Stefano Volpi Katherine B. Sims Jolan E. Walter Elisabetta Traggiai |
| author_facet | Melissa A. Walker Stefano Volpi Katherine B. Sims Jolan E. Walter Elisabetta Traggiai |
| author_sort | Melissa A. Walker |
| collection | DOAJ |
| description | Mitochondria are critical subcellular organelles that are required for several metabolic processes, including oxidative phosphorylation, as well as signaling and tissue-specific processes. Current understanding of the role of mitochondria in both the innate and adaptive immune systems is expanding. Concurrently, immunodeficiencies arising from perturbation of mitochondrial elements are increasingly recognized. Recent observations of immune dysfunction and increased incidence of infection in patients with primary mitochondrial disorders further support an important role for mitochondria in the proper function of the immune system. Here we review current findings. |
| format | Article |
| id | doaj-art-b51131e2575447809ffcf29ff1acbb7e |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-b51131e2575447809ffcf29ff1acbb7e2025-02-03T05:45:29ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/164309164309Powering the Immune System: Mitochondria in Immune Function and DeficiencyMelissa A. Walker0Stefano Volpi1Katherine B. Sims2Jolan E. Walter3Elisabetta Traggiai4Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USADepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, 16147 Genova, ItalyDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02114, USADivision of Allergy and Immunology, Department of Pediatrics, Massachusetts General Hospital for Children, Boston, MA 02114, USANovartis Institute for Research in Biomedicine, Basel, SwitzerlandMitochondria are critical subcellular organelles that are required for several metabolic processes, including oxidative phosphorylation, as well as signaling and tissue-specific processes. Current understanding of the role of mitochondria in both the innate and adaptive immune systems is expanding. Concurrently, immunodeficiencies arising from perturbation of mitochondrial elements are increasingly recognized. Recent observations of immune dysfunction and increased incidence of infection in patients with primary mitochondrial disorders further support an important role for mitochondria in the proper function of the immune system. Here we review current findings.http://dx.doi.org/10.1155/2014/164309 |
| spellingShingle | Melissa A. Walker Stefano Volpi Katherine B. Sims Jolan E. Walter Elisabetta Traggiai Powering the Immune System: Mitochondria in Immune Function and Deficiency Journal of Immunology Research |
| title | Powering the Immune System: Mitochondria in Immune Function and Deficiency |
| title_full | Powering the Immune System: Mitochondria in Immune Function and Deficiency |
| title_fullStr | Powering the Immune System: Mitochondria in Immune Function and Deficiency |
| title_full_unstemmed | Powering the Immune System: Mitochondria in Immune Function and Deficiency |
| title_short | Powering the Immune System: Mitochondria in Immune Function and Deficiency |
| title_sort | powering the immune system mitochondria in immune function and deficiency |
| url | http://dx.doi.org/10.1155/2014/164309 |
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