Ferritin nanocage loading lycopene for improving blood-brain barrier transcytosis and attenuating D-galactose-induced apoptosis in PC12 cells
Aging is a physiological process that leads to degeneration and functional decline of the brain. This is accompanied by intracellular peroxidation and neuronal apoptosis. Natural antioxidants possess a remarkable effect on attenuating the oxidative stress cascade and apoptosis of neurons; however, t...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2025-03-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2024.9250057 |
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| author | Xiaoyu Xia Han Li Xianbing Xu Zhenyu Wang Junjie Yi Guanghua Zhao Ming Du |
| author_facet | Xiaoyu Xia Han Li Xianbing Xu Zhenyu Wang Junjie Yi Guanghua Zhao Ming Du |
| author_sort | Xiaoyu Xia |
| collection | DOAJ |
| description | Aging is a physiological process that leads to degeneration and functional decline of the brain. This is accompanied by intracellular peroxidation and neuronal apoptosis. Natural antioxidants possess a remarkable effect on attenuating the oxidative stress cascade and apoptosis of neurons; however, the challenge of using natural antioxidants for neuroprotection is fabricating a delivery system to overcome the blood-brain barrier (BBB) transport. Herein, we successfully created a stable delivery platform built on rigid ferritin nanocage loading natural lycopene molecules, crossing the BBB in quantity and being taken up in neurons. This nanoparticle worked on D-galactose-induced senescence via alleviating neuronal hyperoxidation injury and weakening neuronal apoptosis in PC12 and BV2 cells. More importantly, this natural delivery system possesses inherent biocompatibility and potential application in improving the bioavailability of bioactive edible compounds with low water solubility. This study demonstrated the effectiveness of natural antioxidant nanomedicines in maintaining the defenses of intracerebral peroxidation and improve degenerating neurons, providing the potential to combat further imbalances of neuronal microenvironment in aging neuropathy. |
| format | Article |
| id | doaj-art-b50de17d93ac4d90bafd6030909d72ec |
| institution | DOAJ |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-b50de17d93ac4d90bafd6030909d72ec2025-08-20T02:41:14ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302025-03-01143925005710.26599/FSHW.2024.9250057Ferritin nanocage loading lycopene for improving blood-brain barrier transcytosis and attenuating D-galactose-induced apoptosis in PC12 cellsXiaoyu Xia0Han Li1Xianbing Xu2Zhenyu Wang3Junjie Yi4Guanghua Zhao5Ming Du6School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, ChinaSchool of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, ChinaSchool of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, ChinaSchool of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, ChinaFaculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, ChinaCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaSchool of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, ChinaAging is a physiological process that leads to degeneration and functional decline of the brain. This is accompanied by intracellular peroxidation and neuronal apoptosis. Natural antioxidants possess a remarkable effect on attenuating the oxidative stress cascade and apoptosis of neurons; however, the challenge of using natural antioxidants for neuroprotection is fabricating a delivery system to overcome the blood-brain barrier (BBB) transport. Herein, we successfully created a stable delivery platform built on rigid ferritin nanocage loading natural lycopene molecules, crossing the BBB in quantity and being taken up in neurons. This nanoparticle worked on D-galactose-induced senescence via alleviating neuronal hyperoxidation injury and weakening neuronal apoptosis in PC12 and BV2 cells. More importantly, this natural delivery system possesses inherent biocompatibility and potential application in improving the bioavailability of bioactive edible compounds with low water solubility. This study demonstrated the effectiveness of natural antioxidant nanomedicines in maintaining the defenses of intracerebral peroxidation and improve degenerating neurons, providing the potential to combat further imbalances of neuronal microenvironment in aging neuropathy.https://www.sciopen.com/article/10.26599/FSHW.2024.9250057ferritinlycopenenanocarrierneuroprotectionaging |
| spellingShingle | Xiaoyu Xia Han Li Xianbing Xu Zhenyu Wang Junjie Yi Guanghua Zhao Ming Du Ferritin nanocage loading lycopene for improving blood-brain barrier transcytosis and attenuating D-galactose-induced apoptosis in PC12 cells Food Science and Human Wellness ferritin lycopene nanocarrier neuroprotection aging |
| title | Ferritin nanocage loading lycopene for improving blood-brain barrier transcytosis and attenuating D-galactose-induced apoptosis in PC12 cells |
| title_full | Ferritin nanocage loading lycopene for improving blood-brain barrier transcytosis and attenuating D-galactose-induced apoptosis in PC12 cells |
| title_fullStr | Ferritin nanocage loading lycopene for improving blood-brain barrier transcytosis and attenuating D-galactose-induced apoptosis in PC12 cells |
| title_full_unstemmed | Ferritin nanocage loading lycopene for improving blood-brain barrier transcytosis and attenuating D-galactose-induced apoptosis in PC12 cells |
| title_short | Ferritin nanocage loading lycopene for improving blood-brain barrier transcytosis and attenuating D-galactose-induced apoptosis in PC12 cells |
| title_sort | ferritin nanocage loading lycopene for improving blood brain barrier transcytosis and attenuating d galactose induced apoptosis in pc12 cells |
| topic | ferritin lycopene nanocarrier neuroprotection aging |
| url | https://www.sciopen.com/article/10.26599/FSHW.2024.9250057 |
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