Iron and ferroptosis in kidney disease: molecular and metabolic mechanisms
Maintaining iron homeostasis is necessary for kidney functioning. There is more and more research indicating that kidney disease is often caused by iron imbalance. Over the past decade, ferroptosis’ role in mediating the development and progression of renal disorders, such as acute kidney injury (re...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1531577/full |
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| author | Wenjie Wang Jingdi Chen Liying Zhan Handong Zou Lu Wang Mengmeng Guo Hang Gao Jing Xu Wei Wu |
| author_facet | Wenjie Wang Jingdi Chen Liying Zhan Handong Zou Lu Wang Mengmeng Guo Hang Gao Jing Xu Wei Wu |
| author_sort | Wenjie Wang |
| collection | DOAJ |
| description | Maintaining iron homeostasis is necessary for kidney functioning. There is more and more research indicating that kidney disease is often caused by iron imbalance. Over the past decade, ferroptosis’ role in mediating the development and progression of renal disorders, such as acute kidney injury (renal ischemia-reperfusion injury, drug-induced acute kidney injury, severe acute pancreatitis induced acute kidney injury and sepsis-associated acute kidney injury), chronic kidney disease (diabetic nephropathy, renal fibrosis, autosomal dominant polycystic kidney disease) and renal cell carcinoma, has come into focus. Thus, knowing kidney iron metabolism and ferroptosis regulation may enhance disease therapy. In this review, we discuss the metabolic and molecular mechanisms of iron signaling and ferroptosis in kidney disease. We also explore the possible targets of ferroptosis in the therapy of renal illness, as well as their existing limitations and future strategies. |
| format | Article |
| id | doaj-art-b508ff6a2d3040fc8705634c20e8b5e1 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-b508ff6a2d3040fc8705634c20e8b5e12025-02-05T05:17:51ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011610.3389/fimmu.2025.15315771531577Iron and ferroptosis in kidney disease: molecular and metabolic mechanismsWenjie Wang0Jingdi Chen1Liying Zhan2Handong Zou3Lu Wang4Mengmeng Guo5Hang Gao6Jing Xu7Wei Wu8Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaDepartment of orthopedics, The Airborne Military Hospital, Wuhan, Hubei, ChinaDepartment of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaDepartment of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaDepartment of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaThe First Clinical College of Wuhan University, Wuhan, Hubei, ChinaDepartment of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaDepartment of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaDepartment of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaMaintaining iron homeostasis is necessary for kidney functioning. There is more and more research indicating that kidney disease is often caused by iron imbalance. Over the past decade, ferroptosis’ role in mediating the development and progression of renal disorders, such as acute kidney injury (renal ischemia-reperfusion injury, drug-induced acute kidney injury, severe acute pancreatitis induced acute kidney injury and sepsis-associated acute kidney injury), chronic kidney disease (diabetic nephropathy, renal fibrosis, autosomal dominant polycystic kidney disease) and renal cell carcinoma, has come into focus. Thus, knowing kidney iron metabolism and ferroptosis regulation may enhance disease therapy. In this review, we discuss the metabolic and molecular mechanisms of iron signaling and ferroptosis in kidney disease. We also explore the possible targets of ferroptosis in the therapy of renal illness, as well as their existing limitations and future strategies.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1531577/fullkidney diseaseferroptosismechanismtreatmentmetabolic |
| spellingShingle | Wenjie Wang Jingdi Chen Liying Zhan Handong Zou Lu Wang Mengmeng Guo Hang Gao Jing Xu Wei Wu Iron and ferroptosis in kidney disease: molecular and metabolic mechanisms Frontiers in Immunology kidney disease ferroptosis mechanism treatment metabolic |
| title | Iron and ferroptosis in kidney disease: molecular and metabolic mechanisms |
| title_full | Iron and ferroptosis in kidney disease: molecular and metabolic mechanisms |
| title_fullStr | Iron and ferroptosis in kidney disease: molecular and metabolic mechanisms |
| title_full_unstemmed | Iron and ferroptosis in kidney disease: molecular and metabolic mechanisms |
| title_short | Iron and ferroptosis in kidney disease: molecular and metabolic mechanisms |
| title_sort | iron and ferroptosis in kidney disease molecular and metabolic mechanisms |
| topic | kidney disease ferroptosis mechanism treatment metabolic |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1531577/full |
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