Emerging role of gut microbiota extracellular vesicle in neurodegenerative disorders and insights on their therapeutic management
Abstract Targeting gut flora to lower sickness risk is a growing scientific subject. The intricate network of microorganisms (gut microbiota) in the human intestines regulates many physiological systems and may be important for general health. Recent research has shown a dynamic relationship between...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | iMetaOmics |
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| Online Access: | https://doi.org/10.1002/imo2.33 |
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| author | Adil Hassan Yin Huang Mahjabina Otmilda Hapsari Sudiro Xiangxiu Wang Jingqin He Yan Wei Xiaoling Liao Guixue Wang |
| author_facet | Adil Hassan Yin Huang Mahjabina Otmilda Hapsari Sudiro Xiangxiu Wang Jingqin He Yan Wei Xiaoling Liao Guixue Wang |
| author_sort | Adil Hassan |
| collection | DOAJ |
| description | Abstract Targeting gut flora to lower sickness risk is a growing scientific subject. The intricate network of microorganisms (gut microbiota) in the human intestines regulates many physiological systems and may be important for general health. Recent research has shown a dynamic relationship between gut microbiota and central nervous system (CNS). Dysbiosis is key to establishing and progressing human diseases, including neurodegenerative disorders. Recently, gut microbiota extracellular vesicles (GMEVs) have been suggested as brain‐gut communication carriers. Vesicle components contact immune receptors, initiating neuroinflammatory immune responses and causing neurodegenerative diseases. This study seeks to explain how the gut microbiota and its extracellular vesicles cause or worsen neurodegenerative diseases. We also highlighted recent advances in our understanding of these GMEVs' and cargo's routes, which could be used in drug delivery treatments. This study also examines the current state and potential therapeutic effects of GMEVs on neurodegenerative illnesses. |
| format | Article |
| id | doaj-art-b50502e1413542aaa7725e7fbbf2157c |
| institution | Kabale University |
| issn | 2996-9506 2996-9514 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | iMetaOmics |
| spelling | doaj-art-b50502e1413542aaa7725e7fbbf2157c2025-01-31T16:15:24ZengWileyiMetaOmics2996-95062996-95142024-12-0112n/an/a10.1002/imo2.33Emerging role of gut microbiota extracellular vesicle in neurodegenerative disorders and insights on their therapeutic managementAdil Hassan0Yin Huang1Mahjabina2Otmilda Hapsari Sudiro3Xiangxiu Wang4Jingqin He5Yan Wei6Xiaoling Liao7Guixue Wang8Department of Materials Science, college of Materials and New Energy, Chongqing Key Laboratory of Nano/Micro Composite Materials and Devices Chongqing University of Science and Technology Chongqing ChinaDepartment of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical University Chongqing ChinaDepartment of Bioengining, College of Bioengineering, Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College Chongqing University Chongqing ChinaDepartment of Bioengining, College of Bioengineering, Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College Chongqing University Chongqing ChinaJinFeng Laboratory Chongqing ChinaDepartment of Materials Science, college of Materials and New Energy, Chongqing Key Laboratory of Nano/Micro Composite Materials and Devices Chongqing University of Science and Technology Chongqing ChinaInstitute of Cardiovascular Research, Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province Southwest Medical University Luzhou Sichuan ChinaDepartment of Materials Science, college of Materials and New Energy, Chongqing Key Laboratory of Nano/Micro Composite Materials and Devices Chongqing University of Science and Technology Chongqing ChinaJinFeng Laboratory Chongqing ChinaAbstract Targeting gut flora to lower sickness risk is a growing scientific subject. The intricate network of microorganisms (gut microbiota) in the human intestines regulates many physiological systems and may be important for general health. Recent research has shown a dynamic relationship between gut microbiota and central nervous system (CNS). Dysbiosis is key to establishing and progressing human diseases, including neurodegenerative disorders. Recently, gut microbiota extracellular vesicles (GMEVs) have been suggested as brain‐gut communication carriers. Vesicle components contact immune receptors, initiating neuroinflammatory immune responses and causing neurodegenerative diseases. This study seeks to explain how the gut microbiota and its extracellular vesicles cause or worsen neurodegenerative diseases. We also highlighted recent advances in our understanding of these GMEVs' and cargo's routes, which could be used in drug delivery treatments. This study also examines the current state and potential therapeutic effects of GMEVs on neurodegenerative illnesses.https://doi.org/10.1002/imo2.33brain dysfunctiondrug delivery systemgut microbiota extracellular vesicleneurodegenerative disordersneuro‐inflammation |
| spellingShingle | Adil Hassan Yin Huang Mahjabina Otmilda Hapsari Sudiro Xiangxiu Wang Jingqin He Yan Wei Xiaoling Liao Guixue Wang Emerging role of gut microbiota extracellular vesicle in neurodegenerative disorders and insights on their therapeutic management iMetaOmics brain dysfunction drug delivery system gut microbiota extracellular vesicle neurodegenerative disorders neuro‐inflammation |
| title | Emerging role of gut microbiota extracellular vesicle in neurodegenerative disorders and insights on their therapeutic management |
| title_full | Emerging role of gut microbiota extracellular vesicle in neurodegenerative disorders and insights on their therapeutic management |
| title_fullStr | Emerging role of gut microbiota extracellular vesicle in neurodegenerative disorders and insights on their therapeutic management |
| title_full_unstemmed | Emerging role of gut microbiota extracellular vesicle in neurodegenerative disorders and insights on their therapeutic management |
| title_short | Emerging role of gut microbiota extracellular vesicle in neurodegenerative disorders and insights on their therapeutic management |
| title_sort | emerging role of gut microbiota extracellular vesicle in neurodegenerative disorders and insights on their therapeutic management |
| topic | brain dysfunction drug delivery system gut microbiota extracellular vesicle neurodegenerative disorders neuro‐inflammation |
| url | https://doi.org/10.1002/imo2.33 |
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