Targeting Setdb1 in T cells induces transplant tolerance without compromising antitumor immunity

Targeting Setdb1 in T cells induces transplant tolerance without compromising antitumor immunity

Abstract Suppressing immune responses promotes allograft survival but also favours tumour progression and recurrence. Selectively suppressing allograft rejection while maintaining or even enhancing antitumor immunity is challenging. Here, we show loss of allograft-related rejection in mice deficient...

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Main Authors: Xiaosheng Tan, Xiangli Zhao, Zunsong Hu, Ding-Sheng Jiang, Zhibo Ma, Lingjuan Sun, Jingzeng Wang, Xia Huang, Bin Xie, Mi Wu, Min Ma, Cong-Yi Wang, Shu Zhang, Li Chen, Zhishui Chen, Gang Chen, Peixiang Lan
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58841-z
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