Acute effect of hemodialysis on serum levels of the proinflammatory cytokines
Chronic inflammation is a common feature of end-stage renal disease, which carries a heightened risk of atherosclerosis and other co-morbid conditions. Dialysis treatment per se can bring additional risk factors for inflammation, such as increased risk of local graft and fistula infections, impure d...
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| Format: | Article |
| Language: | English |
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Wiley
2003-01-01
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| Series: | Mediators of Inflammation |
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| Online Access: | http://dx.doi.org/10.1080/0962935031000096935 |
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| author | Mehmet Tarakçıoğlu Ayşe Binnur Erbağci Celalettin Usalan Rukiye Deveci Ramazan Kocabaş |
| author_facet | Mehmet Tarakçıoğlu Ayşe Binnur Erbağci Celalettin Usalan Rukiye Deveci Ramazan Kocabaş |
| author_sort | Mehmet Tarakçıoğlu |
| collection | DOAJ |
| description | Chronic inflammation is a common feature of end-stage renal disease, which carries a heightened risk of atherosclerosis and other co-morbid conditions. Dialysis treatment per se can bring additional risk factors for inflammation, such as increased risk of local graft and fistula infections, impure dialysate or bio-incompatible membranes. Our study was designed to determine whether a hemodialysis session leads to an acute substantial alteration in the plasma levels of the proinflammatory cytokines interleukin (IL)-6, IL-1β and tumor necrosis factor (TNF)-α, the T-lymphocyte activation factor soluble IL-2 receptor (sIL-2R), and an inflammation mediator and chemotactic granulocyte factor, IL-8, in end-stage renal disease patients receiving chronic intermittent HD. In this study, 21 (12 male/nine female) patients undergoing chronic hemodialysis were enrolled. The acute effect of a hemodialysis session on serum cytokine concentrations was assessed by comparison of pre-hemodialysis and post-hemodialysis determinations. Serum IL-1β, sIL-2R, IL-6, IL-8 and TNF-α levels were determined with chemiluminescence enzyme immunometric assays. |
| format | Article |
| id | doaj-art-b4ebdf116f804324b5cebbf7ca284bfa |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b4ebdf116f804324b5cebbf7ca284bfa2025-08-20T02:23:31ZengWileyMediators of Inflammation0962-93511466-18612003-01-01121151910.1080/0962935031000096935Acute effect of hemodialysis on serum levels of the proinflammatory cytokinesMehmet Tarakçıoğlu0Ayşe Binnur Erbağci1Celalettin Usalan2Rukiye Deveci3Ramazan Kocabaş4Department of Biochemistry and Clinical Biochemistry, Gaziantep University, Medicine Faculty, Şehitkamil Gaziantep, Gaziantep 27310, TurkeyDepartment of Biochemistry and Clinical Biochemistry, Gaziantep University, Medicine Faculty, Şehitkamil Gaziantep, Gaziantep 27310, TurkeyDepartment of Nephrology, Gaziantep University, Medicine Faculty, Şehitkamil Gaziantep, Gaziantep 27310, TurkeyDepartment of Biochemistry and Clinical Biochemistry, Gaziantep University, Medicine Faculty, Şehitkamil Gaziantep, Gaziantep 27310, TurkeyDepartment of Biochemistry and Clinical Biochemistry, Gaziantep University, Medicine Faculty, Şehitkamil Gaziantep, Gaziantep 27310, TurkeyChronic inflammation is a common feature of end-stage renal disease, which carries a heightened risk of atherosclerosis and other co-morbid conditions. Dialysis treatment per se can bring additional risk factors for inflammation, such as increased risk of local graft and fistula infections, impure dialysate or bio-incompatible membranes. Our study was designed to determine whether a hemodialysis session leads to an acute substantial alteration in the plasma levels of the proinflammatory cytokines interleukin (IL)-6, IL-1β and tumor necrosis factor (TNF)-α, the T-lymphocyte activation factor soluble IL-2 receptor (sIL-2R), and an inflammation mediator and chemotactic granulocyte factor, IL-8, in end-stage renal disease patients receiving chronic intermittent HD. In this study, 21 (12 male/nine female) patients undergoing chronic hemodialysis were enrolled. The acute effect of a hemodialysis session on serum cytokine concentrations was assessed by comparison of pre-hemodialysis and post-hemodialysis determinations. Serum IL-1β, sIL-2R, IL-6, IL-8 and TNF-α levels were determined with chemiluminescence enzyme immunometric assays.http://dx.doi.org/10.1080/0962935031000096935HemodialysisProinflammatory cytokinesSoluble interleukin-2 receptorInterleukin-8Clearance. |
| spellingShingle | Mehmet Tarakçıoğlu Ayşe Binnur Erbağci Celalettin Usalan Rukiye Deveci Ramazan Kocabaş Acute effect of hemodialysis on serum levels of the proinflammatory cytokines Mediators of Inflammation Hemodialysis Proinflammatory cytokines Soluble interleukin-2 receptor Interleukin-8 Clearance. |
| title | Acute effect of hemodialysis on serum levels of the proinflammatory cytokines |
| title_full | Acute effect of hemodialysis on serum levels of the proinflammatory cytokines |
| title_fullStr | Acute effect of hemodialysis on serum levels of the proinflammatory cytokines |
| title_full_unstemmed | Acute effect of hemodialysis on serum levels of the proinflammatory cytokines |
| title_short | Acute effect of hemodialysis on serum levels of the proinflammatory cytokines |
| title_sort | acute effect of hemodialysis on serum levels of the proinflammatory cytokines |
| topic | Hemodialysis Proinflammatory cytokines Soluble interleukin-2 receptor Interleukin-8 Clearance. |
| url | http://dx.doi.org/10.1080/0962935031000096935 |
| work_keys_str_mv | AT mehmettarakcıoglu acuteeffectofhemodialysisonserumlevelsoftheproinflammatorycytokines AT aysebinnurerbagci acuteeffectofhemodialysisonserumlevelsoftheproinflammatorycytokines AT celalettinusalan acuteeffectofhemodialysisonserumlevelsoftheproinflammatorycytokines AT rukiyedeveci acuteeffectofhemodialysisonserumlevelsoftheproinflammatorycytokines AT ramazankocabas acuteeffectofhemodialysisonserumlevelsoftheproinflammatorycytokines |