Neuropsychiatric symptoms in patients with dementia and the longitudinal costs of informal care in the Cache County population
Abstract Introduction Severity of dementia and neuropsychiatric symptoms contribute to increasing informal care costs. We examined which neuropsychiatric symptoms subdomains (NPS‐SD) were associated with informal costs in a population‐based sample. Methods Dementia progression and informal costs (20...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
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| Online Access: | https://doi.org/10.1016/j.trci.2019.01.002 |
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| author | Gail B. Rattinger Chelsea L. Sanders Elizabeth Vernon Sarah Schwartz Stephanie Behrens Constantine G. Lyketsos JoAnn T. Tschanz |
| author_facet | Gail B. Rattinger Chelsea L. Sanders Elizabeth Vernon Sarah Schwartz Stephanie Behrens Constantine G. Lyketsos JoAnn T. Tschanz |
| author_sort | Gail B. Rattinger |
| collection | DOAJ |
| description | Abstract Introduction Severity of dementia and neuropsychiatric symptoms contribute to increasing informal care costs. We examined which neuropsychiatric symptoms subdomains (NPS‐SD) were associated with informal costs in a population‐based sample. Methods Dementia progression and informal costs (2015 dollars) were estimated from the Cache County Dementia Progression Study. Overall NPS and specific NPS‐SD were assessed with the Neuropsychiatric Inventory. Generalized Estimating Equations (GEE with gamma‐distribution/log‐link) modeled the relationship between NPS‐SDs and informal cost trajectories. Results Two hundred eighty participants (52.1% female; age M = 85.67, SD = 5.60) exhibited an adjusted cost increase of 5.6% (P = .005), 6.4% (P < .001), 7.6% (P = .030), and 13% (P = .024) for every increasing Neuropsychiatric Inventory unit in psychosis‐SD, affective‐SD, agitation/aggression‐SD, and apathy‐SD, respectively. An increase in each unit of apathy was associated with a 2% annual decrease in costs (P = .040). Discussion We extend our prior work on informal costs and dementia severity by identifying NPS‐SD associated with informal costs. Interventions targeting NPS‐SD may lower informal costs. |
| format | Article |
| id | doaj-art-b4e0dcbe7ed045bebcf4e678cbca7028 |
| institution | OA Journals |
| issn | 2352-8737 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj-art-b4e0dcbe7ed045bebcf4e678cbca70282025-08-20T02:36:54ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372019-01-0151818810.1016/j.trci.2019.01.002Neuropsychiatric symptoms in patients with dementia and the longitudinal costs of informal care in the Cache County populationGail B. Rattinger0Chelsea L. Sanders1Elizabeth Vernon2Sarah Schwartz3Stephanie Behrens4Constantine G. Lyketsos5JoAnn T. Tschanz6School of Pharmacy and Pharmaceutical Sciences, Binghamton University State University of New YorkNew YorkNYUSADepartment of PsychologyUtah State UniversityLoganUTUSADepartment of PsychologyUtah State UniversityLoganUTUSADepartment of Mathematics and StatisticsUtah State UniversityLoganUTUSADepartment of PsychologyUtah State UniversityLoganUTUSAJohns Hopkins Bayview Medical CenterBaltimoreMDUSADepartment of PsychologyUtah State UniversityLoganUTUSAAbstract Introduction Severity of dementia and neuropsychiatric symptoms contribute to increasing informal care costs. We examined which neuropsychiatric symptoms subdomains (NPS‐SD) were associated with informal costs in a population‐based sample. Methods Dementia progression and informal costs (2015 dollars) were estimated from the Cache County Dementia Progression Study. Overall NPS and specific NPS‐SD were assessed with the Neuropsychiatric Inventory. Generalized Estimating Equations (GEE with gamma‐distribution/log‐link) modeled the relationship between NPS‐SDs and informal cost trajectories. Results Two hundred eighty participants (52.1% female; age M = 85.67, SD = 5.60) exhibited an adjusted cost increase of 5.6% (P = .005), 6.4% (P < .001), 7.6% (P = .030), and 13% (P = .024) for every increasing Neuropsychiatric Inventory unit in psychosis‐SD, affective‐SD, agitation/aggression‐SD, and apathy‐SD, respectively. An increase in each unit of apathy was associated with a 2% annual decrease in costs (P = .040). Discussion We extend our prior work on informal costs and dementia severity by identifying NPS‐SD associated with informal costs. Interventions targeting NPS‐SD may lower informal costs.https://doi.org/10.1016/j.trci.2019.01.002Informal costs of dementiaNeuropsychiatric symptomsDementiaAlzheimer's disease |
| spellingShingle | Gail B. Rattinger Chelsea L. Sanders Elizabeth Vernon Sarah Schwartz Stephanie Behrens Constantine G. Lyketsos JoAnn T. Tschanz Neuropsychiatric symptoms in patients with dementia and the longitudinal costs of informal care in the Cache County population Alzheimer’s & Dementia: Translational Research & Clinical Interventions Informal costs of dementia Neuropsychiatric symptoms Dementia Alzheimer's disease |
| title | Neuropsychiatric symptoms in patients with dementia and the longitudinal costs of informal care in the Cache County population |
| title_full | Neuropsychiatric symptoms in patients with dementia and the longitudinal costs of informal care in the Cache County population |
| title_fullStr | Neuropsychiatric symptoms in patients with dementia and the longitudinal costs of informal care in the Cache County population |
| title_full_unstemmed | Neuropsychiatric symptoms in patients with dementia and the longitudinal costs of informal care in the Cache County population |
| title_short | Neuropsychiatric symptoms in patients with dementia and the longitudinal costs of informal care in the Cache County population |
| title_sort | neuropsychiatric symptoms in patients with dementia and the longitudinal costs of informal care in the cache county population |
| topic | Informal costs of dementia Neuropsychiatric symptoms Dementia Alzheimer's disease |
| url | https://doi.org/10.1016/j.trci.2019.01.002 |
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