Ephedra extract-mediated gold nanoparticles on Kaolin: A natural approach for reduction and stabilization, with evaluation of antioxidant and anti-ovarian cancer activities
A straightforward, efficient, and environmentally friendly method has been developed to synthesize gold nanoparticles (Au NPs) supported on kaolin with no harmful additives, ephedra flower extract acts as a biogenic stabilizing and reducing agent. An analysis of the Au NPs/Kaolin composite's st...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Journal of Science: Advanced Materials and Devices |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468217925000061 |
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| author | Hui Yang Cui Wang Qingjiang Wang Feng Han |
| author_facet | Hui Yang Cui Wang Qingjiang Wang Feng Han |
| author_sort | Hui Yang |
| collection | DOAJ |
| description | A straightforward, efficient, and environmentally friendly method has been developed to synthesize gold nanoparticles (Au NPs) supported on kaolin with no harmful additives, ephedra flower extract acts as a biogenic stabilizing and reducing agent. An analysis of the Au NPs/Kaolin composite's structural properties was conducted using FE-SEM, TEM, EDX, and XRD assays. The biological activity of the composite was evaluated through cytotoxicity tests using the MTT assay. In addition, its potential anti-ovarian cancer properties were tested against several ovarian cancer cell lines, including TOV-21G, OV-90, SW 626, and UWB1.289, with IC50 values found to be 112, 250, 278, and 243 μg/mL, respectively. The ovarian cancer cell lines showed a dose-dependent decline in % cell viability. The HUVEC cell line was also used to evaluate the material's biocompatibility with normal cells. Based on the results, the bio-composite material is found promising as a therapeutic agent for treating human ovarian cancer. |
| format | Article |
| id | doaj-art-b4d97d16bf7c44afa092ba24478020b0 |
| institution | Kabale University |
| issn | 2468-2179 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Science: Advanced Materials and Devices |
| spelling | doaj-art-b4d97d16bf7c44afa092ba24478020b02025-02-06T05:12:38ZengElsevierJournal of Science: Advanced Materials and Devices2468-21792025-06-01102100853Ephedra extract-mediated gold nanoparticles on Kaolin: A natural approach for reduction and stabilization, with evaluation of antioxidant and anti-ovarian cancer activitiesHui Yang0Cui Wang1Qingjiang Wang2Feng Han3Department of Gynecology, Yantaishan Hospital, Yantai, Shandong, 264000, ChinaDepartment of Traditional Chinese Medicine, Ezhou Central Hospital, Ezhou, Hubei, 436000, ChinaDepartment of Equipment Section, YantaiQishanhospital, Yantai, Shandong, 264001, ChinaGynecology and Obstetrics, Xi 'an Qin Huang Hospital, Xi'an, Shaanxi, 710600, China; Corresponding author.A straightforward, efficient, and environmentally friendly method has been developed to synthesize gold nanoparticles (Au NPs) supported on kaolin with no harmful additives, ephedra flower extract acts as a biogenic stabilizing and reducing agent. An analysis of the Au NPs/Kaolin composite's structural properties was conducted using FE-SEM, TEM, EDX, and XRD assays. The biological activity of the composite was evaluated through cytotoxicity tests using the MTT assay. In addition, its potential anti-ovarian cancer properties were tested against several ovarian cancer cell lines, including TOV-21G, OV-90, SW 626, and UWB1.289, with IC50 values found to be 112, 250, 278, and 243 μg/mL, respectively. The ovarian cancer cell lines showed a dose-dependent decline in % cell viability. The HUVEC cell line was also used to evaluate the material's biocompatibility with normal cells. Based on the results, the bio-composite material is found promising as a therapeutic agent for treating human ovarian cancer.http://www.sciencedirect.com/science/article/pii/S2468217925000061Au NPsKaolinEphedraOvarian carcinomaMTT assay |
| spellingShingle | Hui Yang Cui Wang Qingjiang Wang Feng Han Ephedra extract-mediated gold nanoparticles on Kaolin: A natural approach for reduction and stabilization, with evaluation of antioxidant and anti-ovarian cancer activities Journal of Science: Advanced Materials and Devices Au NPs Kaolin Ephedra Ovarian carcinoma MTT assay |
| title | Ephedra extract-mediated gold nanoparticles on Kaolin: A natural approach for reduction and stabilization, with evaluation of antioxidant and anti-ovarian cancer activities |
| title_full | Ephedra extract-mediated gold nanoparticles on Kaolin: A natural approach for reduction and stabilization, with evaluation of antioxidant and anti-ovarian cancer activities |
| title_fullStr | Ephedra extract-mediated gold nanoparticles on Kaolin: A natural approach for reduction and stabilization, with evaluation of antioxidant and anti-ovarian cancer activities |
| title_full_unstemmed | Ephedra extract-mediated gold nanoparticles on Kaolin: A natural approach for reduction and stabilization, with evaluation of antioxidant and anti-ovarian cancer activities |
| title_short | Ephedra extract-mediated gold nanoparticles on Kaolin: A natural approach for reduction and stabilization, with evaluation of antioxidant and anti-ovarian cancer activities |
| title_sort | ephedra extract mediated gold nanoparticles on kaolin a natural approach for reduction and stabilization with evaluation of antioxidant and anti ovarian cancer activities |
| topic | Au NPs Kaolin Ephedra Ovarian carcinoma MTT assay |
| url | http://www.sciencedirect.com/science/article/pii/S2468217925000061 |
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