Suppressed Programmed Death 1 Expression on CD4+ and CD8+ T Cells in Psoriatic Patients
Psoriasis is a chronic inflammatory disease mediated by T cell immunity. Programmed death 1 (PD-1), a coinhibitory receptor, plays an important role in immune regulation and maintaining peripheral tolerance. The aim of the study was to compare the expression of PD-1 on the peripheral T cells between...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/5385102 |
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| author | Joanna Bartosińska Ewelina Zakrzewska Dorota Raczkiewicz Joanna Purkot Anna Michalak-Stoma Małgorzata Kowal Dorota Krasowska Grażyna Chodorowska Krzysztof Giannopoulos |
| author_facet | Joanna Bartosińska Ewelina Zakrzewska Dorota Raczkiewicz Joanna Purkot Anna Michalak-Stoma Małgorzata Kowal Dorota Krasowska Grażyna Chodorowska Krzysztof Giannopoulos |
| author_sort | Joanna Bartosińska |
| collection | DOAJ |
| description | Psoriasis is a chronic inflammatory disease mediated by T cell immunity. Programmed death 1 (PD-1), a coinhibitory receptor, plays an important role in immune regulation and maintaining peripheral tolerance. The aim of the study was to compare the expression of PD-1 on the peripheral T cells between psoriatic patients and healthy controls. The study included 75 psoriatic patients and 52 healthy volunteers. The percentages and absolute numbers of CD3+, CD4+, CD8+, CD4+PD-1+, and CD8+PD-1+ T cells were analyzed using flow cytometry. The absolute numbers and percentages of CD4+PD-1+ and CD8+PD-1+ T cells were significantly decreased in the psoriatic patients in comparison with the control group. No significant correlations were found between the absolute numbers and percentages of CD4+PD-1+ or CD8+PD-1+ T cells and clinical characteristics of psoriasis. Decreased PD-1 expression on the T cells may be responsible for impaired negative regulation of immune response in psoriasis pathogenesis. |
| format | Article |
| id | doaj-art-b4d66bf008c84a6ebadaf619a24bd317 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b4d66bf008c84a6ebadaf619a24bd3172025-02-03T00:59:18ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/53851025385102Suppressed Programmed Death 1 Expression on CD4+ and CD8+ T Cells in Psoriatic PatientsJoanna Bartosińska0Ewelina Zakrzewska1Dorota Raczkiewicz2Joanna Purkot3Anna Michalak-Stoma4Małgorzata Kowal5Dorota Krasowska6Grażyna Chodorowska7Krzysztof Giannopoulos8Department of Dermatology, Venereology and Paediatric Dermatology, Medical University of Lublin, Lublin, PolandExperimental Hematooncology Department, Medical University of Lublin, Lublin, PolandInstitute of Statistics and Demography, Warsaw School of Economics, Warsaw, PolandExperimental Hematooncology Department, Medical University of Lublin, Lublin, PolandDepartment of Dermatology, Venereology and Paediatric Dermatology, Medical University of Lublin, Lublin, PolandDepartment of Dermatology, Venereology and Paediatric Dermatology, Medical University of Lublin, Lublin, PolandDepartment of Dermatology, Venereology and Paediatric Dermatology, Medical University of Lublin, Lublin, PolandDepartment of Dermatology, Venereology and Paediatric Dermatology, Medical University of Lublin, Lublin, PolandExperimental Hematooncology Department, Medical University of Lublin, Lublin, PolandPsoriasis is a chronic inflammatory disease mediated by T cell immunity. Programmed death 1 (PD-1), a coinhibitory receptor, plays an important role in immune regulation and maintaining peripheral tolerance. The aim of the study was to compare the expression of PD-1 on the peripheral T cells between psoriatic patients and healthy controls. The study included 75 psoriatic patients and 52 healthy volunteers. The percentages and absolute numbers of CD3+, CD4+, CD8+, CD4+PD-1+, and CD8+PD-1+ T cells were analyzed using flow cytometry. The absolute numbers and percentages of CD4+PD-1+ and CD8+PD-1+ T cells were significantly decreased in the psoriatic patients in comparison with the control group. No significant correlations were found between the absolute numbers and percentages of CD4+PD-1+ or CD8+PD-1+ T cells and clinical characteristics of psoriasis. Decreased PD-1 expression on the T cells may be responsible for impaired negative regulation of immune response in psoriasis pathogenesis.http://dx.doi.org/10.1155/2017/5385102 |
| spellingShingle | Joanna Bartosińska Ewelina Zakrzewska Dorota Raczkiewicz Joanna Purkot Anna Michalak-Stoma Małgorzata Kowal Dorota Krasowska Grażyna Chodorowska Krzysztof Giannopoulos Suppressed Programmed Death 1 Expression on CD4+ and CD8+ T Cells in Psoriatic Patients Mediators of Inflammation |
| title | Suppressed Programmed Death 1 Expression on CD4+ and CD8+ T Cells in Psoriatic Patients |
| title_full | Suppressed Programmed Death 1 Expression on CD4+ and CD8+ T Cells in Psoriatic Patients |
| title_fullStr | Suppressed Programmed Death 1 Expression on CD4+ and CD8+ T Cells in Psoriatic Patients |
| title_full_unstemmed | Suppressed Programmed Death 1 Expression on CD4+ and CD8+ T Cells in Psoriatic Patients |
| title_short | Suppressed Programmed Death 1 Expression on CD4+ and CD8+ T Cells in Psoriatic Patients |
| title_sort | suppressed programmed death 1 expression on cd4 and cd8 t cells in psoriatic patients |
| url | http://dx.doi.org/10.1155/2017/5385102 |
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