Mechanisms Linking Vitamin D Deficiency to Impaired Metabolism: An Overview
Vitamin D deficiency is a common health problem worldwide. Despite its known skeletal effects, studies have begun to explore its extra-skeletal effects, that is, in preventing metabolic diseases such as obesity, hyperlipidemia, and diabetes mellitus. The mechanisms by which vitamin D deficiency led...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2022/6453882 |
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| _version_ | 1832558408034680832 |
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| author | Nurulmuna Mohd Ghozali Nelli Giribabu Naguib Salleh |
| author_facet | Nurulmuna Mohd Ghozali Nelli Giribabu Naguib Salleh |
| author_sort | Nurulmuna Mohd Ghozali |
| collection | DOAJ |
| description | Vitamin D deficiency is a common health problem worldwide. Despite its known skeletal effects, studies have begun to explore its extra-skeletal effects, that is, in preventing metabolic diseases such as obesity, hyperlipidemia, and diabetes mellitus. The mechanisms by which vitamin D deficiency led to these unfavorable metabolic consequences have been explored. Current evidence indicates that the deficiency of vitamin D could impair the pancreatic β-cell functions, thus compromising its insulin secretion. Besides, vitamin D deficiency could also exacerbate inflammation, oxidative stress, and apoptosis in the pancreas and many organs, which leads to insulin resistance. Together, these will contribute to impairment in glucose homeostasis. This review summarizes the reported metabolic effects of vitamin D, in order to identify its potential use to prevent and overcome metabolic diseases. |
| format | Article |
| id | doaj-art-b4c65ea7b4e24d3aa95178c429433451 |
| institution | Kabale University |
| issn | 1687-8345 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-b4c65ea7b4e24d3aa95178c4294334512025-02-03T01:32:27ZengWileyInternational Journal of Endocrinology1687-83452022-01-01202210.1155/2022/6453882Mechanisms Linking Vitamin D Deficiency to Impaired Metabolism: An OverviewNurulmuna Mohd Ghozali0Nelli Giribabu1Naguib Salleh2Department of PhysiologyDepartment of PhysiologyDepartment of PhysiologyVitamin D deficiency is a common health problem worldwide. Despite its known skeletal effects, studies have begun to explore its extra-skeletal effects, that is, in preventing metabolic diseases such as obesity, hyperlipidemia, and diabetes mellitus. The mechanisms by which vitamin D deficiency led to these unfavorable metabolic consequences have been explored. Current evidence indicates that the deficiency of vitamin D could impair the pancreatic β-cell functions, thus compromising its insulin secretion. Besides, vitamin D deficiency could also exacerbate inflammation, oxidative stress, and apoptosis in the pancreas and many organs, which leads to insulin resistance. Together, these will contribute to impairment in glucose homeostasis. This review summarizes the reported metabolic effects of vitamin D, in order to identify its potential use to prevent and overcome metabolic diseases.http://dx.doi.org/10.1155/2022/6453882 |
| spellingShingle | Nurulmuna Mohd Ghozali Nelli Giribabu Naguib Salleh Mechanisms Linking Vitamin D Deficiency to Impaired Metabolism: An Overview International Journal of Endocrinology |
| title | Mechanisms Linking Vitamin D Deficiency to Impaired Metabolism: An Overview |
| title_full | Mechanisms Linking Vitamin D Deficiency to Impaired Metabolism: An Overview |
| title_fullStr | Mechanisms Linking Vitamin D Deficiency to Impaired Metabolism: An Overview |
| title_full_unstemmed | Mechanisms Linking Vitamin D Deficiency to Impaired Metabolism: An Overview |
| title_short | Mechanisms Linking Vitamin D Deficiency to Impaired Metabolism: An Overview |
| title_sort | mechanisms linking vitamin d deficiency to impaired metabolism an overview |
| url | http://dx.doi.org/10.1155/2022/6453882 |
| work_keys_str_mv | AT nurulmunamohdghozali mechanismslinkingvitaminddeficiencytoimpairedmetabolismanoverview AT nelligiribabu mechanismslinkingvitaminddeficiencytoimpairedmetabolismanoverview AT naguibsalleh mechanismslinkingvitaminddeficiencytoimpairedmetabolismanoverview |