The Photobiology of Lutein and Zeaxanthin in the Eye
Lutein and zeaxanthin are antioxidants found in the human retina and macula. Recent clinical trials have determined that age- and diet-related loss of lutein and zeaxanthin enhances phototoxic damage to the human eye and that supplementation of these carotenoids has a protective effect against photo...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2015/687173 |
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| author | Joan E. Roberts Jessica Dennison |
| author_facet | Joan E. Roberts Jessica Dennison |
| author_sort | Joan E. Roberts |
| collection | DOAJ |
| description | Lutein and zeaxanthin are antioxidants found in the human retina and macula. Recent clinical trials have determined that age- and diet-related loss of lutein and zeaxanthin enhances phototoxic damage to the human eye and that supplementation of these carotenoids has a protective effect against photoinduced damage to the lens and the retina. Two of the major mechanisms of protection offered by lutein and zeaxanthin against age-related blue light damage are the quenching of singlet oxygen and other reactive oxygen species and the absorption of blue light. Determining the specific reactive intermediate(s) produced by a particular phototoxic ocular chromophore not only defines the mechanism of toxicity but can also later be used as a tool to prevent damage. |
| format | Article |
| id | doaj-art-b4b1a9ca5d864b698eaa57b2bb215261 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-b4b1a9ca5d864b698eaa57b2bb2152612025-02-03T01:33:02ZengWileyJournal of Ophthalmology2090-004X2090-00582015-01-01201510.1155/2015/687173687173The Photobiology of Lutein and Zeaxanthin in the EyeJoan E. Roberts0Jessica Dennison1Department of Natural Sciences, Fordham University, New York City, NY 10023, USADepartment of Natural Sciences, Fordham University, New York City, NY 10023, USALutein and zeaxanthin are antioxidants found in the human retina and macula. Recent clinical trials have determined that age- and diet-related loss of lutein and zeaxanthin enhances phototoxic damage to the human eye and that supplementation of these carotenoids has a protective effect against photoinduced damage to the lens and the retina. Two of the major mechanisms of protection offered by lutein and zeaxanthin against age-related blue light damage are the quenching of singlet oxygen and other reactive oxygen species and the absorption of blue light. Determining the specific reactive intermediate(s) produced by a particular phototoxic ocular chromophore not only defines the mechanism of toxicity but can also later be used as a tool to prevent damage.http://dx.doi.org/10.1155/2015/687173 |
| spellingShingle | Joan E. Roberts Jessica Dennison The Photobiology of Lutein and Zeaxanthin in the Eye Journal of Ophthalmology |
| title | The Photobiology of Lutein and Zeaxanthin in the Eye |
| title_full | The Photobiology of Lutein and Zeaxanthin in the Eye |
| title_fullStr | The Photobiology of Lutein and Zeaxanthin in the Eye |
| title_full_unstemmed | The Photobiology of Lutein and Zeaxanthin in the Eye |
| title_short | The Photobiology of Lutein and Zeaxanthin in the Eye |
| title_sort | photobiology of lutein and zeaxanthin in the eye |
| url | http://dx.doi.org/10.1155/2015/687173 |
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