Heme Oxygenase-1: A Critical Link between Iron Metabolism, Erythropoiesis, and Development
The first mature cells to arise in the developing mammalian embryo belong to the erythroid lineage. This highlights the immediacy of the need for red blood cells during embryogenesis and for survival. Linked with this pressure is the necessity of the embryo to obtain and transport iron, synthesize h...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2011/473709 |
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| author | Stuart T. Fraser Robyn G. Midwinter Birgit S. Berger Roland Stocker |
| author_facet | Stuart T. Fraser Robyn G. Midwinter Birgit S. Berger Roland Stocker |
| author_sort | Stuart T. Fraser |
| collection | DOAJ |
| description | The first mature cells to arise in the developing mammalian embryo belong to the erythroid lineage. This highlights the immediacy of the need for red blood cells during embryogenesis and for survival. Linked with this pressure is the necessity of the embryo to obtain and transport iron, synthesize hemoglobin, and then dispose of the potentially toxic heme via the stress-induced protein heme oxygenase-1 (HO-1, encoded by Hmox1 in the mouse). Null mutation of Hmox1 results in significant embryonic mortality as well as anemia and defective iron recycling. Here, we discuss the interrelated nature of this critical enzyme with iron trafficking, erythroid cell function, and embryonic survival. |
| format | Article |
| id | doaj-art-b4af3104f0f34a8e990d86bd894f5063 |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-b4af3104f0f34a8e990d86bd894f50632025-02-03T06:06:41ZengWileyAdvances in Hematology1687-91041687-91122011-01-01201110.1155/2011/473709473709Heme Oxygenase-1: A Critical Link between Iron Metabolism, Erythropoiesis, and DevelopmentStuart T. Fraser0Robyn G. Midwinter1Birgit S. Berger2Roland Stocker3Laboratory for Blood Cell Development, Disciplines of Physiology, Anatomy and Histology, School of Medical Sciences and Bosch Institute, University of Sydney, Medical Foundation Building, 92-94 Parramatta Road, Camperdown, NSW 2050, AustraliaCenter for Vascular Research, Discipline of Pathology, School of Medical Sciences and Bosch Institute, University of Sydney, Medical Foundation Building, 92–94 Parramatta Road, Camperdown, NSW 2050, AustraliaCenter for Vascular Research, Discipline of Pathology, School of Medical Sciences and Bosch Institute, University of Sydney, Medical Foundation Building, 92–94 Parramatta Road, Camperdown, NSW 2050, AustraliaCenter for Vascular Research, Discipline of Pathology, School of Medical Sciences and Bosch Institute, University of Sydney, Medical Foundation Building, 92–94 Parramatta Road, Camperdown, NSW 2050, AustraliaThe first mature cells to arise in the developing mammalian embryo belong to the erythroid lineage. This highlights the immediacy of the need for red blood cells during embryogenesis and for survival. Linked with this pressure is the necessity of the embryo to obtain and transport iron, synthesize hemoglobin, and then dispose of the potentially toxic heme via the stress-induced protein heme oxygenase-1 (HO-1, encoded by Hmox1 in the mouse). Null mutation of Hmox1 results in significant embryonic mortality as well as anemia and defective iron recycling. Here, we discuss the interrelated nature of this critical enzyme with iron trafficking, erythroid cell function, and embryonic survival.http://dx.doi.org/10.1155/2011/473709 |
| spellingShingle | Stuart T. Fraser Robyn G. Midwinter Birgit S. Berger Roland Stocker Heme Oxygenase-1: A Critical Link between Iron Metabolism, Erythropoiesis, and Development Advances in Hematology |
| title | Heme Oxygenase-1: A Critical Link between Iron Metabolism, Erythropoiesis, and Development |
| title_full | Heme Oxygenase-1: A Critical Link between Iron Metabolism, Erythropoiesis, and Development |
| title_fullStr | Heme Oxygenase-1: A Critical Link between Iron Metabolism, Erythropoiesis, and Development |
| title_full_unstemmed | Heme Oxygenase-1: A Critical Link between Iron Metabolism, Erythropoiesis, and Development |
| title_short | Heme Oxygenase-1: A Critical Link between Iron Metabolism, Erythropoiesis, and Development |
| title_sort | heme oxygenase 1 a critical link between iron metabolism erythropoiesis and development |
| url | http://dx.doi.org/10.1155/2011/473709 |
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