From inflammation to malignancy: ginsenosides as a bridge between traditional healing and modern therapies for periodontitis and oral cancer
Periodontal disease and oral cancer are major global health issues, with periodontitis leading to tooth loss and linked to systemic diseases. Oral squamous cell carcinoma (OSCC), a leading cause of morbidity and mortality, is strongly associated with risk factors such as poor oral hygiene, smoking,...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-08-01
|
| Series: | Phytomedicine Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667031325000995 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849232646753746944 |
|---|---|
| author | Meysam Hosseinzadeh Hassan Bazvand Ehsan Gravand Mohammad Hossein Pourhanifeh |
| author_facet | Meysam Hosseinzadeh Hassan Bazvand Ehsan Gravand Mohammad Hossein Pourhanifeh |
| author_sort | Meysam Hosseinzadeh |
| collection | DOAJ |
| description | Periodontal disease and oral cancer are major global health issues, with periodontitis leading to tooth loss and linked to systemic diseases. Oral squamous cell carcinoma (OSCC), a leading cause of morbidity and mortality, is strongly associated with risk factors such as poor oral hygiene, smoking, and alcohol consumption. There is a connection between these conditions, as periodontal disease may elevate the risk of oral cancer through chronic inflammation and microbial dysbiosis. Ginsenosides, bioactive compounds found in ginseng, show promise for their therapeutic effects on both conditions. These saponins possess anti-inflammatory, antioxidant, and anticancer properties, and recent studies indicate they can modulate immune responses, inhibit tumor growth, and lower inflammatory markers in periodontitis by suppressing pro-inflammatory cytokines like IL-6 and TNF-α. This review discusses the therapeutic potential of ginsenosides in treating periodontitis and oral cancer, focusing on the underlying mechanisms. |
| format | Article |
| id | doaj-art-b4ae2b2aa8b5498f9e5e3ee8dfb283f0 |
| institution | Kabale University |
| issn | 2667-0313 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj-art-b4ae2b2aa8b5498f9e5e3ee8dfb283f02025-08-21T04:17:29ZengElsevierPhytomedicine Plus2667-03132025-08-015310082710.1016/j.phyplu.2025.100827From inflammation to malignancy: ginsenosides as a bridge between traditional healing and modern therapies for periodontitis and oral cancerMeysam Hosseinzadeh0Hassan Bazvand1Ehsan Gravand2Mohammad Hossein Pourhanifeh3Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, IranDepartment of Periodontics, School of Dental Medicine, Lorestan University of Medical Sciences, Khorramabad, IranDepartment of Periodontics, School of Dental Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran; Corresponding author at: Department of Periodontics, School of Dental Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.Research Hub Institute, Tehran, Iran; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran; Corresponding author at: Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.Periodontal disease and oral cancer are major global health issues, with periodontitis leading to tooth loss and linked to systemic diseases. Oral squamous cell carcinoma (OSCC), a leading cause of morbidity and mortality, is strongly associated with risk factors such as poor oral hygiene, smoking, and alcohol consumption. There is a connection between these conditions, as periodontal disease may elevate the risk of oral cancer through chronic inflammation and microbial dysbiosis. Ginsenosides, bioactive compounds found in ginseng, show promise for their therapeutic effects on both conditions. These saponins possess anti-inflammatory, antioxidant, and anticancer properties, and recent studies indicate they can modulate immune responses, inhibit tumor growth, and lower inflammatory markers in periodontitis by suppressing pro-inflammatory cytokines like IL-6 and TNF-α. This review discusses the therapeutic potential of ginsenosides in treating periodontitis and oral cancer, focusing on the underlying mechanisms.http://www.sciencedirect.com/science/article/pii/S2667031325000995GinsengPeriodontitisOral cancerOral microbiomeApoptosisNatural compound |
| spellingShingle | Meysam Hosseinzadeh Hassan Bazvand Ehsan Gravand Mohammad Hossein Pourhanifeh From inflammation to malignancy: ginsenosides as a bridge between traditional healing and modern therapies for periodontitis and oral cancer Phytomedicine Plus Ginseng Periodontitis Oral cancer Oral microbiome Apoptosis Natural compound |
| title | From inflammation to malignancy: ginsenosides as a bridge between traditional healing and modern therapies for periodontitis and oral cancer |
| title_full | From inflammation to malignancy: ginsenosides as a bridge between traditional healing and modern therapies for periodontitis and oral cancer |
| title_fullStr | From inflammation to malignancy: ginsenosides as a bridge between traditional healing and modern therapies for periodontitis and oral cancer |
| title_full_unstemmed | From inflammation to malignancy: ginsenosides as a bridge between traditional healing and modern therapies for periodontitis and oral cancer |
| title_short | From inflammation to malignancy: ginsenosides as a bridge between traditional healing and modern therapies for periodontitis and oral cancer |
| title_sort | from inflammation to malignancy ginsenosides as a bridge between traditional healing and modern therapies for periodontitis and oral cancer |
| topic | Ginseng Periodontitis Oral cancer Oral microbiome Apoptosis Natural compound |
| url | http://www.sciencedirect.com/science/article/pii/S2667031325000995 |
| work_keys_str_mv | AT meysamhosseinzadeh frominflammationtomalignancyginsenosidesasabridgebetweentraditionalhealingandmoderntherapiesforperiodontitisandoralcancer AT hassanbazvand frominflammationtomalignancyginsenosidesasabridgebetweentraditionalhealingandmoderntherapiesforperiodontitisandoralcancer AT ehsangravand frominflammationtomalignancyginsenosidesasabridgebetweentraditionalhealingandmoderntherapiesforperiodontitisandoralcancer AT mohammadhosseinpourhanifeh frominflammationtomalignancyginsenosidesasabridgebetweentraditionalhealingandmoderntherapiesforperiodontitisandoralcancer |