Mucus-penetrating microbiota drive chronic low-grade intestinal inflammation and metabolic dysregulation
Metabolic syndrome is, in humans, associated with alterations in the composition and localization of the intestinal microbiota, including encroachment of bacteria within the colon’s inner mucus layer. Possible promoters of these events include dietary emulsifiers, such as carboxymethylcellulose (CMC...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2025.2455790 |
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| author | Melissa C. Kordahi Noëmie Daniel Andrew T. Gewirtz Benoit Chassaing |
| author_facet | Melissa C. Kordahi Noëmie Daniel Andrew T. Gewirtz Benoit Chassaing |
| author_sort | Melissa C. Kordahi |
| collection | DOAJ |
| description | Metabolic syndrome is, in humans, associated with alterations in the composition and localization of the intestinal microbiota, including encroachment of bacteria within the colon’s inner mucus layer. Possible promoters of these events include dietary emulsifiers, such as carboxymethylcellulose (CMC) and polysorbate-80 (P80), which, in mice, result in altered microbiota composition, encroachment, low-grade inflammation and metabolic syndrome. While assessments of gut microbiota composition have largely focused on fecal/luminal samples, we hypothesize an outsized role for changes in mucus microbiota in driving low-grade inflammation and its consequences. In support of this notion, we herein report that both CMC and P80 led to stark changes in the mucus microbiome, markedly distinct from those observed in feces. Moreover, transfer of mucus microbiota from CMC- and P80-fed mice to germfree mice resulted in microbiota encroachment, low-grade inflammation, and various features of metabolic syndrome. Thus, we conclude that mucus-associated bacteria are pivotal determinants of intestinal inflammatory tone and host metabolism. |
| format | Article |
| id | doaj-art-b4a2a649737246469a625063cfe23827 |
| institution | Kabale University |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-b4a2a649737246469a625063cfe238272025-01-27T04:04:03ZengTaylor & Francis GroupGut Microbes1949-09761949-09842025-12-0117110.1080/19490976.2025.2455790Mucus-penetrating microbiota drive chronic low-grade intestinal inflammation and metabolic dysregulationMelissa C. Kordahi0Noëmie Daniel1Andrew T. Gewirtz2Benoit Chassaing3Microbiome-Host Interactions, Institut Pasteur, Université Paris Cité, INSERM U1306, CNRS UMR6047, Paris, FranceMicrobiome-Host Interactions, Institut Pasteur, Université Paris Cité, INSERM U1306, CNRS UMR6047, Paris, FranceInstitute for Biomedical Sciences, Centre for Inflammation, Immunity and Infection, Digestive Disease Research Group, Georgia State University, Atlanta, GA, USAMicrobiome-Host Interactions, Institut Pasteur, Université Paris Cité, INSERM U1306, CNRS UMR6047, Paris, FranceMetabolic syndrome is, in humans, associated with alterations in the composition and localization of the intestinal microbiota, including encroachment of bacteria within the colon’s inner mucus layer. Possible promoters of these events include dietary emulsifiers, such as carboxymethylcellulose (CMC) and polysorbate-80 (P80), which, in mice, result in altered microbiota composition, encroachment, low-grade inflammation and metabolic syndrome. While assessments of gut microbiota composition have largely focused on fecal/luminal samples, we hypothesize an outsized role for changes in mucus microbiota in driving low-grade inflammation and its consequences. In support of this notion, we herein report that both CMC and P80 led to stark changes in the mucus microbiome, markedly distinct from those observed in feces. Moreover, transfer of mucus microbiota from CMC- and P80-fed mice to germfree mice resulted in microbiota encroachment, low-grade inflammation, and various features of metabolic syndrome. Thus, we conclude that mucus-associated bacteria are pivotal determinants of intestinal inflammatory tone and host metabolism.https://www.tandfonline.com/doi/10.1080/19490976.2025.2455790Microbiotamucusencroachmentinflammationmetabolic deregulations |
| spellingShingle | Melissa C. Kordahi Noëmie Daniel Andrew T. Gewirtz Benoit Chassaing Mucus-penetrating microbiota drive chronic low-grade intestinal inflammation and metabolic dysregulation Gut Microbes Microbiota mucus encroachment inflammation metabolic deregulations |
| title | Mucus-penetrating microbiota drive chronic low-grade intestinal inflammation and metabolic dysregulation |
| title_full | Mucus-penetrating microbiota drive chronic low-grade intestinal inflammation and metabolic dysregulation |
| title_fullStr | Mucus-penetrating microbiota drive chronic low-grade intestinal inflammation and metabolic dysregulation |
| title_full_unstemmed | Mucus-penetrating microbiota drive chronic low-grade intestinal inflammation and metabolic dysregulation |
| title_short | Mucus-penetrating microbiota drive chronic low-grade intestinal inflammation and metabolic dysregulation |
| title_sort | mucus penetrating microbiota drive chronic low grade intestinal inflammation and metabolic dysregulation |
| topic | Microbiota mucus encroachment inflammation metabolic deregulations |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2025.2455790 |
| work_keys_str_mv | AT melissackordahi mucuspenetratingmicrobiotadrivechroniclowgradeintestinalinflammationandmetabolicdysregulation AT noemiedaniel mucuspenetratingmicrobiotadrivechroniclowgradeintestinalinflammationandmetabolicdysregulation AT andrewtgewirtz mucuspenetratingmicrobiotadrivechroniclowgradeintestinalinflammationandmetabolicdysregulation AT benoitchassaing mucuspenetratingmicrobiotadrivechroniclowgradeintestinalinflammationandmetabolicdysregulation |