Specific determination of hepatitis B e antigen by antibodies targeting precore unique epitope facilitates clinical diagnosis and drug evaluation against hepatitis B virus infection

Specific determination of hepatitis B e antigen by antibodies targeting precore unique epitope facilitates clinical diagnosis and drug evaluation against hepatitis B virus infection

Hepatitis B e antigen (HBeAg) is a widely used marker both for chronic hepatitis B (CHB) clinical management and HBV-related basic research. However, due to its high amino acid sequence homology to hepatitis B core antigen (HBcAg), most of available anti-HBe antibodies are cross-reactive with HBcAg...

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Main Authors: Shao-Juan Wang, Zi-Min Chen, Min Wei, Jia-Qi Liu, Zong-Lin Li, Tian-Shu Shi, Sheng Nian, Rao Fu, Yang-Tao Wu, Ya-Li Zhang, Ying-Bin Wang, Tian-Ying Zhang, Jun Zhang, Jun-Hui Xiong, Shu-Ping Tong, Sheng-Xiang Ge, Quan Yuan, Ning-Shao Xia
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Emerging Microbes and Infections
Subjects:
Hepatitis B virus
Hepatitis B e antigen
monoclonal antibody
cccDNA surrogate
immunoassay
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2020.1862631
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https://www.tandfonline.com/doi/10.1080/22221751.2020.1862631

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