Role of Neutrophil Gelatinase-Associated Lipocalin in the Diagnosis and Early Treatment of Acute Kidney Injury in a Case Series of Patients with Acute Decompensated Heart Failure: A Case Series
Patients with acute decompensated heart failure (ADHF) frequently develop worsening in renal function until Acute Kidney Injury (AKI). The use of kidney injury biomarkers could be useful in the early diagnosis of AKI. In the present study, the role of the neutrophil gelatinase-associated lipocalin (...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/3708210 |
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| author | Silvia Angeletti Marta Fogolari Davide Morolla Federico Capone Sebastiano Costantino Silvia Spoto Marina De Cesaris Alessandra Lo Presti Massimo Ciccozzi Giordano Dicuonzo |
| author_facet | Silvia Angeletti Marta Fogolari Davide Morolla Federico Capone Sebastiano Costantino Silvia Spoto Marina De Cesaris Alessandra Lo Presti Massimo Ciccozzi Giordano Dicuonzo |
| author_sort | Silvia Angeletti |
| collection | DOAJ |
| description | Patients with acute decompensated heart failure (ADHF) frequently develop worsening in renal function until Acute Kidney Injury (AKI). The use of kidney injury biomarkers could be useful in the early diagnosis of AKI. In the present study, the role of the neutrophil gelatinase-associated lipocalin (NGAL), compared to the standard creatinine, in ADHF patients, was analyzed to evaluate if an early treatment could affect the outcome. A case series of 24 ADHF patients was enrolled and patients randomly divided in two groups (Group A and Group B). In Group A, NGAL, creatinine, and eGFR were measured, while in Group B, creatinine and eGFR alone were measured. NGAL was measured by turbidimetric immunoassay and creatinine using an enzymatic spectrophotometric method. In presence of AKI, creatinine increase and eGFR decrease were significantly lower in Group A than in Group B, whereas in absence of AKI the difference between the two groups was not significant. Hospitalization stay was significantly lower in Group A (receiving early treatment based on NGAL) than in Group B. In ADHF patients, plasma NGAL in combination with creatinine was superior to the standard creatinine in the diagnosis and early treatment of AKI with a better outcome and a decreased hospital stay. |
| format | Article |
| id | doaj-art-b49bd41f14a24175b6893f92e29b0fcd |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-b49bd41f14a24175b6893f92e29b0fcd2025-02-03T01:29:58ZengWileyCardiology Research and Practice2090-80162090-05972016-01-01201610.1155/2016/37082103708210Role of Neutrophil Gelatinase-Associated Lipocalin in the Diagnosis and Early Treatment of Acute Kidney Injury in a Case Series of Patients with Acute Decompensated Heart Failure: A Case SeriesSilvia Angeletti0Marta Fogolari1Davide Morolla2Federico Capone3Sebastiano Costantino4Silvia Spoto5Marina De Cesaris6Alessandra Lo Presti7Massimo Ciccozzi8Giordano Dicuonzo9Clinical Pathology and Microbiology Laboratory, University Hospital Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Rome, ItalyClinical Pathology and Microbiology Laboratory, University Hospital Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Rome, ItalyInternal Medicine Department, University Hospital Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Rome, ItalyInternal Medicine Department, University Hospital Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Rome, ItalyInternal Medicine Department, University Hospital Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Rome, ItalyInternal Medicine Department, University Hospital Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Rome, ItalyClinical Pathology and Microbiology Laboratory, University Hospital Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Rome, ItalyDepartment of Infectious, Parasitic and Immunomediated Diseases, National Institute of Health, Viale Regina Elena 299, 00161 Rome, ItalyClinical Pathology and Microbiology Laboratory, University Hospital Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Rome, ItalyClinical Pathology and Microbiology Laboratory, University Hospital Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Rome, ItalyPatients with acute decompensated heart failure (ADHF) frequently develop worsening in renal function until Acute Kidney Injury (AKI). The use of kidney injury biomarkers could be useful in the early diagnosis of AKI. In the present study, the role of the neutrophil gelatinase-associated lipocalin (NGAL), compared to the standard creatinine, in ADHF patients, was analyzed to evaluate if an early treatment could affect the outcome. A case series of 24 ADHF patients was enrolled and patients randomly divided in two groups (Group A and Group B). In Group A, NGAL, creatinine, and eGFR were measured, while in Group B, creatinine and eGFR alone were measured. NGAL was measured by turbidimetric immunoassay and creatinine using an enzymatic spectrophotometric method. In presence of AKI, creatinine increase and eGFR decrease were significantly lower in Group A than in Group B, whereas in absence of AKI the difference between the two groups was not significant. Hospitalization stay was significantly lower in Group A (receiving early treatment based on NGAL) than in Group B. In ADHF patients, plasma NGAL in combination with creatinine was superior to the standard creatinine in the diagnosis and early treatment of AKI with a better outcome and a decreased hospital stay.http://dx.doi.org/10.1155/2016/3708210 |
| spellingShingle | Silvia Angeletti Marta Fogolari Davide Morolla Federico Capone Sebastiano Costantino Silvia Spoto Marina De Cesaris Alessandra Lo Presti Massimo Ciccozzi Giordano Dicuonzo Role of Neutrophil Gelatinase-Associated Lipocalin in the Diagnosis and Early Treatment of Acute Kidney Injury in a Case Series of Patients with Acute Decompensated Heart Failure: A Case Series Cardiology Research and Practice |
| title | Role of Neutrophil Gelatinase-Associated Lipocalin in the Diagnosis and Early Treatment of Acute Kidney Injury in a Case Series of Patients with Acute Decompensated Heart Failure: A Case Series |
| title_full | Role of Neutrophil Gelatinase-Associated Lipocalin in the Diagnosis and Early Treatment of Acute Kidney Injury in a Case Series of Patients with Acute Decompensated Heart Failure: A Case Series |
| title_fullStr | Role of Neutrophil Gelatinase-Associated Lipocalin in the Diagnosis and Early Treatment of Acute Kidney Injury in a Case Series of Patients with Acute Decompensated Heart Failure: A Case Series |
| title_full_unstemmed | Role of Neutrophil Gelatinase-Associated Lipocalin in the Diagnosis and Early Treatment of Acute Kidney Injury in a Case Series of Patients with Acute Decompensated Heart Failure: A Case Series |
| title_short | Role of Neutrophil Gelatinase-Associated Lipocalin in the Diagnosis and Early Treatment of Acute Kidney Injury in a Case Series of Patients with Acute Decompensated Heart Failure: A Case Series |
| title_sort | role of neutrophil gelatinase associated lipocalin in the diagnosis and early treatment of acute kidney injury in a case series of patients with acute decompensated heart failure a case series |
| url | http://dx.doi.org/10.1155/2016/3708210 |
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