Interpreting results from biomarker-guided clinical trials: avoiding “negative” or “failed” terminology

Interpreting results from biomarker-guided clinical trials: avoiding “negative” or “failed” terminology

Saved in:

Bibliographic Details
Main Authors:	Nurulamin M. Noor, Haiyan Zheng, David S. Robertson, Joshua Savage, Christina Yap, Andrea L. Jorgensen, James M. S. Wason, on behalf of the MRC-NIHR Trial Methodology Research Partnership (TMRP) Precision Medicine Working Group
Format:	Article
Language:	English
Published:	BMC 2025-05-01
Series:	BMC Medicine
Subjects:	Biomarkers Biomarker-driven Biomarker-guided Biomarker-stratified Precision medicine Clinical trials
Online Access:	https://doi.org/10.1186/s12916-025-04035-9
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Rheumatoid Arthritis Prevention: catalysing PlatfORm Trial delivery (RAPPORT)
by: Michelle Bardgett, et al.
Published: (2025-02-01)

New insights into biomarkers and risk stratification to predict hepatocellular cancer
by: Katrina Li, et al.
Published: (2025-04-01)

Psychotic relapse prediction via biomarker monitoring: a systematic review
by: Alexandros Smyrnis, et al.
Published: (2024-12-01)

Biomarkers in spinal muscular atrophy
by: Liping Yan, et al.
Published: (2025-07-01)

Precision Medicine in Age-Related Macular Degeneration: Current Approaches and Future Directions
by: Mehrdad Motamed Shariati
Published: (2025-03-01)

Master protocols in vocal biomarker development to reduce variability and advance clinical precision: a narrative review
by: Ayush Kalia, et al.
Published: (2025-06-01)

Diagnostic biomarkers for active tuberculosis: progress and challenges
by: Betânia M F Nogueira, et al.
Published: (2022-10-01)

Tissue Biomarkers in Gastric Cancer Treatment: Present and Future
by: Giulia Airò, et al.
Published: (2024-11-01)

Vitamin E Intake Attenuated the Association Between Elevated Blood Heavy Metal (Pb, Cd, and Hg) Concentrations and Diabetes Risk in Adults Aged 18–65 Years: Findings from 2007–2018 NHANES
by: Chenggang Yang, et al.
Published: (2024-12-01)

Retrospective analysis of inflammatory biomarkers and prognosis in non-small cell lung cancer without adenocarcinoma in situ
by: Qing Zhao, et al.
Published: (2025-03-01)

DEFINING CYTOKINES CONTENTS IN SOLVING MAIN CUNICAL ISSUES
by: V. S. Shirinskiy, et al.
Published: (2012-05-01)

Non-sputum-based samples and biomarkers for detection of Mycobacterium tuberculosis: the hope to improve childhood and HIV-associated tuberculosis diagnosis
by: George W. Kasule, et al.
Published: (2024-10-01)

Exploring CISD1 as a multifaceted biomarker in cancer: Implications for diagnosis, prognosis, and immunotherapeutic response
by: Caiyue Li, et al.
Published: (2025-11-01)

Obesity Biomarkers: Exploring Factors, Ramification, Machine Learning, and AI‐Unveiling Insights in Health Research
by: Ankita Awari, et al.
Published: (2025-07-01)

The Bridge2AI-voice application: initial feasibility study of voice data acquisition through mobile health
by: Elijah Moothedan, et al.
Published: (2025-04-01)

Advancements in Parkinson’s Disease Diagnosis: A Comprehensive Survey on Biomarker Integration and Machine Learning
by: Ruchira Pratihar, et al.
Published: (2024-11-01)

Innovative approach to the detection of circulating tumor biomarkers: multi-dimensional application of liposome technology
by: Weichu Tan, et al.
Published: (2025-04-01)

Predictive Biomarkers in the Management of Bladder Cancer: Perspectives in an Evolving Therapeutic Landscape
by: Patrick J. Hensley, et al.
Published: (2022-07-01)

Circulating apelin levels fail to link sarcopenia-related muscle parameters in older adults
by: Eunhye Ji, et al.
Published: (2025-03-01)

Role of metabolomic changes in diagnosis and assessment of treatment response in acute myeloid leukemia
by: Shabbir Hussain, et al.
Published: (2025-08-01)

The assessment of breast cancer biomarkers in diagnosis, prognosis and treatment monitoring: integrated analysis
by: Patrycja Królewska-Daszczyńska, et al.
Published: (2025-08-01)

Signatures of Six Autophagy‐Related Genes as Diagnostic Markers of Thyroid‐Associated Ophthalmopathy and Their Correlation With Immune Infiltration
by: Qintao Ma, et al.
Published: (2024-12-01)

Relationship between DLK-1 levels in blood serum and survival of patients with glioblastoma
by: A. I. Ryabova, et al.
Published: (2025-01-01)

Cerebrospinal Fluid Biomarkers of Alzheimer Disease
by: Kseniya V. Nevzorova, et al.
Published: (2025-06-01)

Navigating the Landscape of Plasma Biomarkers in Alzheimer's Disease: Focus on Past, Present, and Future Clinical Applications
by: Sarrah E. Ankeny, et al.
Published: (2024-09-01)

Circulating miRNAs as liquid biopsy biomarkers for diagnosis in patients with colorectal cancer: a systematic review and meta-analysis
by: Sydney Schwab, et al.
Published: (2025-07-01)

The diagnostic and prognostic value of C1orf174 in colorectal cancer
by: Elham Nazari, et al.
Published: (2024-11-01)

Non-invasive biomarkers to diagnose and monitor eosinophilic esophagitis: a systematic review
by: Sophia-Louise Noble, et al.
Published: (2025-06-01)

Development of Neurodegenerative Disease Diagnosis and Monitoring from Traditional to Digital Biomarkers
by: Jaeyoon Song, et al.
Published: (2025-02-01)

Circulating Galectin-3: A Prognostic Biomarker in Hepatocellular Carcinoma
by: Shadi Chamseddine, et al.
Published: (2024-11-01)

Proteomic discovery analysis of quantitatively assessed emphysema in the general population. The MESA Lung Study
by: Daniel E. Guzman, et al.
Published: (2025-07-01)

CHIT1 and DDAH1 levels relate to amyloid-related imaging abnormalities risk profile in Alzheimer’s disease patients
by: Marlies Oosthoek, et al.
Published: (2025-07-01)

Oxytocin in horse saliva: validation of a highly sensitive assay and a pilot report about changes in equine gastric ulcer syndrome
by: María Botía, et al.
Published: (2025-02-01)

Bioinformatic analysis of ferroptosis related biomarkers and potential therapeutic targets in vitiligo
by: Linli Liu, et al.
Published: (2025-01-01)

Introduction to the forensic research via omics markers in environmental health vulnerable areas (FROM) study
by: Jung-Yeon Kwon, et al.
Published: (2024-07-01)

Chronic Obstructive Pulmonary Disease and Metabolic Syndrome: A Maltese Study on Biomarkers and Clinical Implications
by: Gauci J, et al.
Published: (2025-07-01)

Impact of sevoflurane anesthesia on S-adenosylmethionine in neonates under general anesthesia
by: Saraswathi Nagappa, et al.
Published: (2025-04-01)

Plasma Matrix Metalloproteinases Signature as Biomarkers for Pediatric Tuberculosis Diagnosis: A Prospective Case–Control Study
by: Nathella Pavan Kumar, et al.
Published: (2025-05-01)

Deciphering Radiotherapy Resistance: A Proteomic Perspective
by: Davide Perico, et al.
Published: (2025-06-01)

The clinical significance of proadrenomedulin level in blood in sepsis patients
by: V. A. Rudnov, et al.
Published: (2019-11-01)