Phasing millions of samples achieves near perfect accuracy, enabling parent-of-origin analyses

Phasing millions of samples achieves near perfect accuracy, enabling parent-of-origin analyses

Summary: Haplotype phasing, the process of determining which genetic variants are physically located on the same chromosome, is crucial for genetic analyses. Here, we benchmark SHAPEIT and Beagle, two state-of-the-art phasing methods, on two large datasets: >8 million research-consented 23andMe,...

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Bibliographic Details
Main Authors: Cole M. Williams, Jared O’Connell, Ethan Jewett, William A. Freyman, Christopher R. Gignoux, Sohini Ramachandran, Amy L. Williams
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:HGG Advances
Subjects:
haplotype phasing
identity-by-descent
population genetics
statistical phasing
parent-of-origin
inheritance
Online Access:http://www.sciencedirect.com/science/article/pii/S266624772500082X
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http://www.sciencedirect.com/science/article/pii/S266624772500082X

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