Phytochemicals in Breast Cancer Prevention and Treatment: A Comprehensive Review
Extensive investigation has been conducted on plant-based resources for their pharmacological usefulness, including various cancer types. The scope of this review is wider than several studies with a particular focus on breast cancer, which is an international health concern while studying sources o...
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2025-01-01
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| author | Adil Farooq Wali Jayachithra Ramakrishna Pillai Sirajunisa Talath Pooja Shivappa Sathvik Belagodu Sridhar Mohamed El-Tanani Imran Rashid Rangraze Omnia Ibrahim Mohamed Nowar Nizar Al Ani |
| author_facet | Adil Farooq Wali Jayachithra Ramakrishna Pillai Sirajunisa Talath Pooja Shivappa Sathvik Belagodu Sridhar Mohamed El-Tanani Imran Rashid Rangraze Omnia Ibrahim Mohamed Nowar Nizar Al Ani |
| author_sort | Adil Farooq Wali |
| collection | DOAJ |
| description | Extensive investigation has been conducted on plant-based resources for their pharmacological usefulness, including various cancer types. The scope of this review is wider than several studies with a particular focus on breast cancer, which is an international health concern while studying sources of flavonoids, carotenoids, polyphenols, saponins, phenolic compounds, terpenoids, and glycosides apart from focusing on nursing. Important findings from prior studies are synthesized to explore these compounds’ sources, mechanisms of action, complementary and synergistic effects, and associated side effects. It was reviewed that the exposure to certain doses of catechins, piperlongumine, lycopene, isoflavones and cucurbitacinfor a sufficient period can provide profound anticancer benefits through biological events such as cell cycle arrest, cells undergoing apoptosis and disruption of signaling pathways including, but not limited to JAK-STAT3, HER2-integrin, and MAPK. Besides, the study also covers the potential adverse effects of these phytochemicals. Regarding mechanisms, the widest attention is paid to Complementary and synergistic strategies are discussed which indicate that it would be realistic to alter the dosage and delivery systems of liposomes, nanoparticles, nanoemulsions, and films to enhance efficacy. Future research directions include refining these delivery approaches, further elucidating molecular mechanisms, and conducting clinical trials to validate findings. These efforts could significantly advance the role of phytocompounds in breast cancer management. |
| format | Article |
| id | doaj-art-b482c34fafe84686b47e4fae00436f0d |
| institution | Kabale University |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Current Issues in Molecular Biology |
| spelling | doaj-art-b482c34fafe84686b47e4fae00436f0d2025-01-24T13:27:27ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452025-01-014713010.3390/cimb47010030Phytochemicals in Breast Cancer Prevention and Treatment: A Comprehensive ReviewAdil Farooq Wali0Jayachithra Ramakrishna Pillai1Sirajunisa Talath2Pooja Shivappa3Sathvik Belagodu Sridhar4Mohamed El-Tanani5Imran Rashid Rangraze6Omnia Ibrahim Mohamed7Nowar Nizar Al Ani8Department of Pharmaceutical Chemistry, College of Pharmacy, RAK Medical and Health Sciences University, Ras Al Khaimah 11172, United Arab EmiratesDepartment of Pharmaceutical Chemistry, College of Pharmacy, RAK Medical and Health Sciences University, Ras Al Khaimah 11172, United Arab EmiratesDepartment of Pharmaceutical Chemistry, College of Pharmacy, RAK Medical and Health Sciences University, Ras Al Khaimah 11172, United Arab EmiratesTranslational Medicinal Research Centre, Department of Biochemistry, RAK Medical and Health Sciences University, Ras Al Khaimah 11172, United Arab EmiratesDepartment of Clinical Pharmacy & Pharmacology, RAK College of Pharmacy, RAK Medical and Health Sciences University, Ras Al Khaimah 11172, United Arab EmiratesRAK College of Pharmacy, RAK Medical and Health Science University, Ras Al Khaimah 11172, United Arab EmiratesRAK College of Medical Sciences, RAK Medical and Health Science University, Ras Al Khaimah 11172, United Arab EmiratesDepartment of General Education, RAK Medical and Health Sciences University, Ras Al Khaimah 11172, United Arab EmiratesDepartment of General Education, RAK Medical and Health Sciences University, Ras Al Khaimah 11172, United Arab EmiratesExtensive investigation has been conducted on plant-based resources for their pharmacological usefulness, including various cancer types. The scope of this review is wider than several studies with a particular focus on breast cancer, which is an international health concern while studying sources of flavonoids, carotenoids, polyphenols, saponins, phenolic compounds, terpenoids, and glycosides apart from focusing on nursing. Important findings from prior studies are synthesized to explore these compounds’ sources, mechanisms of action, complementary and synergistic effects, and associated side effects. It was reviewed that the exposure to certain doses of catechins, piperlongumine, lycopene, isoflavones and cucurbitacinfor a sufficient period can provide profound anticancer benefits through biological events such as cell cycle arrest, cells undergoing apoptosis and disruption of signaling pathways including, but not limited to JAK-STAT3, HER2-integrin, and MAPK. Besides, the study also covers the potential adverse effects of these phytochemicals. Regarding mechanisms, the widest attention is paid to Complementary and synergistic strategies are discussed which indicate that it would be realistic to alter the dosage and delivery systems of liposomes, nanoparticles, nanoemulsions, and films to enhance efficacy. Future research directions include refining these delivery approaches, further elucidating molecular mechanisms, and conducting clinical trials to validate findings. These efforts could significantly advance the role of phytocompounds in breast cancer management.https://www.mdpi.com/1467-3045/47/1/30nanotechnologyanticancer activityflavonoidsapoptosissignaling pathways inhibitionsynergistic effects |
| spellingShingle | Adil Farooq Wali Jayachithra Ramakrishna Pillai Sirajunisa Talath Pooja Shivappa Sathvik Belagodu Sridhar Mohamed El-Tanani Imran Rashid Rangraze Omnia Ibrahim Mohamed Nowar Nizar Al Ani Phytochemicals in Breast Cancer Prevention and Treatment: A Comprehensive Review Current Issues in Molecular Biology nanotechnology anticancer activity flavonoids apoptosis signaling pathways inhibition synergistic effects |
| title | Phytochemicals in Breast Cancer Prevention and Treatment: A Comprehensive Review |
| title_full | Phytochemicals in Breast Cancer Prevention and Treatment: A Comprehensive Review |
| title_fullStr | Phytochemicals in Breast Cancer Prevention and Treatment: A Comprehensive Review |
| title_full_unstemmed | Phytochemicals in Breast Cancer Prevention and Treatment: A Comprehensive Review |
| title_short | Phytochemicals in Breast Cancer Prevention and Treatment: A Comprehensive Review |
| title_sort | phytochemicals in breast cancer prevention and treatment a comprehensive review |
| topic | nanotechnology anticancer activity flavonoids apoptosis signaling pathways inhibition synergistic effects |
| url | https://www.mdpi.com/1467-3045/47/1/30 |
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