Quercetin attenuates cisplatin-induced fatigue through mechanisms associated with the regulation of the HPA axis and MCP-1 signaling
IntroductionCancer-related fatigue (CRF) is a common symptom induced by chemotherapy. The main objective of the present study was to investigate whether quercetin regulates the hypothalamic-pituitary-adrenal (HPA) axis and chemoattractant protein-1 (MCP-1) signaling, two factors contributing to CRF...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1530132/full |
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| author | Cheng-Hung Chuang Yu-An Tai Ting-Jing Wu Ying-Jui Ho Shu-Lan Yeh Shu-Lan Yeh |
| author_facet | Cheng-Hung Chuang Yu-An Tai Ting-Jing Wu Ying-Jui Ho Shu-Lan Yeh Shu-Lan Yeh |
| author_sort | Cheng-Hung Chuang |
| collection | DOAJ |
| description | IntroductionCancer-related fatigue (CRF) is a common symptom induced by chemotherapy. The main objective of the present study was to investigate whether quercetin regulates the hypothalamic-pituitary-adrenal (HPA) axis and chemoattractant protein-1 (MCP-1) signaling, two factors contributing to CRF in mice exposed to cisplatin.MethodsMale BALB/c mice were randomly assigned to the following five groups for 15 weeks: Control, CDDP, CDDP+TAK779 (an antagonist of MCP-1 receptor, human CC chemokine receptor R2 (CCR2)), CDDP+OQ (a diet containing 1% quercetin) and CDDP+IQ (quercetin given by ip, 10 mg/kg, 3 times/week).ResultsThe results first showed that OQ and IQ significantly increased grip strength and locomotor activity, decreased plasma cortisol/corticosterone levels, and decreased the corticotropin releasing hormone (CRH) mRNA level in the brain tissues in mice exposed to CDDP. OQ and IQ also decreased CDDP-induced plasma levels of MCP-1 as well as the mRNA expression of MCP-1 and CCR2 in the brain stem. TAK779 significantly increased grip strength and tended to decrease the cortisol/corticosterone levels in CDDP-exposed mice, indicating the association between the HPA axis and MCP-1 signaling.ConclusionTaken together, the study suggests that quercetin could attenuate CDDP-induced CRF through the mechanisms associated with downregulation of the HPA axis and MCP-1 signaling in mice. |
| format | Article |
| id | doaj-art-b4658876d8bb4e5291c5e75b13651716 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-b4658876d8bb4e5291c5e75b136517162025-01-30T05:10:19ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011210.3389/fnut.2025.15301321530132Quercetin attenuates cisplatin-induced fatigue through mechanisms associated with the regulation of the HPA axis and MCP-1 signalingCheng-Hung Chuang0Yu-An Tai1Ting-Jing Wu2Ying-Jui Ho3Shu-Lan Yeh4Shu-Lan Yeh5Department of Nutrition, Hungkuang University, Taichung, TaiwanDepartment of Nutritional Science, Chung Shan Medical University, Taichung, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung, TaiwanDepartment of Psychology, Chung Shan Medical University, Taichung, TaiwanDepartment of Nutritional Science, Chung Shan Medical University, Taichung, TaiwanDepartment of Nutrition, Chung Shan Medical University Hospital, Taichung, TaiwanIntroductionCancer-related fatigue (CRF) is a common symptom induced by chemotherapy. The main objective of the present study was to investigate whether quercetin regulates the hypothalamic-pituitary-adrenal (HPA) axis and chemoattractant protein-1 (MCP-1) signaling, two factors contributing to CRF in mice exposed to cisplatin.MethodsMale BALB/c mice were randomly assigned to the following five groups for 15 weeks: Control, CDDP, CDDP+TAK779 (an antagonist of MCP-1 receptor, human CC chemokine receptor R2 (CCR2)), CDDP+OQ (a diet containing 1% quercetin) and CDDP+IQ (quercetin given by ip, 10 mg/kg, 3 times/week).ResultsThe results first showed that OQ and IQ significantly increased grip strength and locomotor activity, decreased plasma cortisol/corticosterone levels, and decreased the corticotropin releasing hormone (CRH) mRNA level in the brain tissues in mice exposed to CDDP. OQ and IQ also decreased CDDP-induced plasma levels of MCP-1 as well as the mRNA expression of MCP-1 and CCR2 in the brain stem. TAK779 significantly increased grip strength and tended to decrease the cortisol/corticosterone levels in CDDP-exposed mice, indicating the association between the HPA axis and MCP-1 signaling.ConclusionTaken together, the study suggests that quercetin could attenuate CDDP-induced CRF through the mechanisms associated with downregulation of the HPA axis and MCP-1 signaling in mice.https://www.frontiersin.org/articles/10.3389/fnut.2025.1530132/fullquercetincisplatincancer-related fatigueHPA axisMCP-1 |
| spellingShingle | Cheng-Hung Chuang Yu-An Tai Ting-Jing Wu Ying-Jui Ho Shu-Lan Yeh Shu-Lan Yeh Quercetin attenuates cisplatin-induced fatigue through mechanisms associated with the regulation of the HPA axis and MCP-1 signaling Frontiers in Nutrition quercetin cisplatin cancer-related fatigue HPA axis MCP-1 |
| title | Quercetin attenuates cisplatin-induced fatigue through mechanisms associated with the regulation of the HPA axis and MCP-1 signaling |
| title_full | Quercetin attenuates cisplatin-induced fatigue through mechanisms associated with the regulation of the HPA axis and MCP-1 signaling |
| title_fullStr | Quercetin attenuates cisplatin-induced fatigue through mechanisms associated with the regulation of the HPA axis and MCP-1 signaling |
| title_full_unstemmed | Quercetin attenuates cisplatin-induced fatigue through mechanisms associated with the regulation of the HPA axis and MCP-1 signaling |
| title_short | Quercetin attenuates cisplatin-induced fatigue through mechanisms associated with the regulation of the HPA axis and MCP-1 signaling |
| title_sort | quercetin attenuates cisplatin induced fatigue through mechanisms associated with the regulation of the hpa axis and mcp 1 signaling |
| topic | quercetin cisplatin cancer-related fatigue HPA axis MCP-1 |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1530132/full |
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