Inflammatory rheumatic diseases with onset after SARS-CoV-2 infection or COVID-19 vaccination: a report of 267 cases from the COVID-19 and ASD group
Objectives To better define the spectrum of new-onset post-COVID-19 and post-COVID-19 vaccine inflammatory rheumatic diseases (IRD) from a large multicentric observational study.Methods Consecutive cases of IRD encountered during a 12-month period and satisfying one of the following inclusion criter...
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BMJ Publishing Group
2023-06-01
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| author | Laura Massaro Annamaria Iagnocco Florenzo Iannone Corrado Campochiaro Maria De Santis Ilaria Cavazzana Piero Ruscitti Roberto Giacomelli Rosario Foti Lorenzo Dagna Giovanna Cuomo Giacomo De Luca Francesco Caso Ilenia Di Cola Clodoveo Ferri Vincenzo Raimondo Francesco Ursini Veronica Brusi Giuseppe Varcasia Roberta Pellegrini Domenico Olivo Giuseppe Murdaca Carlo Selmi Olga Addimanda Erika Pigatto Francesca Francioso Rossella De Angelis Jacopo Ciaffi Luana Mancarella Marcella Visentini Francesca Motta Virginia Caira Alberto Lo Gullo Caterina Naclerio Elena Marchetti Sebastiano Lorusso Jessica Luppino Roberta Foti Massimo Reta |
| author_facet | Laura Massaro Annamaria Iagnocco Florenzo Iannone Corrado Campochiaro Maria De Santis Ilaria Cavazzana Piero Ruscitti Roberto Giacomelli Rosario Foti Lorenzo Dagna Giovanna Cuomo Giacomo De Luca Francesco Caso Ilenia Di Cola Clodoveo Ferri Vincenzo Raimondo Francesco Ursini Veronica Brusi Giuseppe Varcasia Roberta Pellegrini Domenico Olivo Giuseppe Murdaca Carlo Selmi Olga Addimanda Erika Pigatto Francesca Francioso Rossella De Angelis Jacopo Ciaffi Luana Mancarella Marcella Visentini Francesca Motta Virginia Caira Alberto Lo Gullo Caterina Naclerio Elena Marchetti Sebastiano Lorusso Jessica Luppino Roberta Foti Massimo Reta |
| author_sort | Laura Massaro |
| collection | DOAJ |
| description | Objectives To better define the spectrum of new-onset post-COVID-19 and post-COVID-19 vaccine inflammatory rheumatic diseases (IRD) from a large multicentric observational study.Methods Consecutive cases of IRD encountered during a 12-month period and satisfying one of the following inclusion criteria: (a) onset of the rheumatic manifestations within 4 weeks from SARS-CoV-2 infection or (b) onset of the rheumatic manifestations within 4 weeks from the administration of one of the COVID-19 vaccines ws recruited.Results The final analysis cohort comprised 267 patients, of which 122 (45.2%) in the post-COVID-19 and 145 (54.8%) in the postvaccine cohort. Distribution of IRD categories differed between the two cohorts: the post-COVID-19 cohort had a higher percentage of patients classified as having inflammatory joint diseases (IJD, 52.5% vs 37.2%, p=0.013) while the post-vaccine cohort had a higher prevalence of patients classified as polymyalgia rheumatica (PMR, 33.1% vs 21.3%, p=0.032). No differences were detected in the percentage of patients diagnosed with connective tissue diseases (CTD 19.7% vs 20.7%, p=0.837) or vasculitis (6.6% vs 9.0%, p=0.467). Despite the short follow-up period, IJD and PMR patients’ response to first-line therapy was favourable, with both groups achieving a drop in baseline disease activity scores of ~30% and ~70% respectively.Conclusion Our article reports the largest cohort published to date of new-onset IRD following SARS-CoV-2 infection or COVID-19 vaccines. Although causality cannot be ascertained, the spectrum of possible clinical manifestations is broad and includes IJD, PMR, CTD and vasculitis. |
| format | Article |
| id | doaj-art-b46499e98e0648859f5100544700ca32 |
| institution | Kabale University |
| issn | 2056-5933 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | RMD Open |
| spelling | doaj-art-b46499e98e0648859f5100544700ca322025-02-06T06:20:10ZengBMJ Publishing GroupRMD Open2056-59332023-06-019210.1136/rmdopen-2023-003022Inflammatory rheumatic diseases with onset after SARS-CoV-2 infection or COVID-19 vaccination: a report of 267 cases from the COVID-19 and ASD groupLaura Massaro0Annamaria Iagnocco1Florenzo Iannone2Corrado Campochiaro3Maria De Santis4Ilaria Cavazzana5Piero Ruscitti6Roberto Giacomelli7Rosario Foti8Lorenzo Dagna9Giovanna Cuomo10Giacomo De Luca11Francesco Caso12Ilenia Di Cola13Clodoveo Ferri14Vincenzo Raimondo15Francesco Ursini16Veronica Brusi17Giuseppe Varcasia18Roberta Pellegrini19Domenico Olivo20Giuseppe Murdaca21Carlo Selmi22Olga Addimanda23Erika Pigatto24Francesca Francioso25Rossella De Angelis26Jacopo Ciaffi27Luana Mancarella28Marcella Visentini29Francesca Motta30Virginia Caira31Alberto Lo Gullo32Caterina Naclerio33Elena Marchetti34Sebastiano Lorusso35Jessica Luppino36Roberta Foti37Massimo Reta381Sapienza, University of Rome, Internal Medicine and Medical Specialties, Rome, ItalyAcademic Rheumatology Centre, Dipartimento Scienze Cliniche Biologiche, Università di Torino - AO Mauriziano Torino, Turin, ItalyRheumatology Unit, DiMePRe-J, University of Bari, Bari, ItalyUnit of Immunology, Rheumatology, Allergy ad Rre Disesaes. IRCCS San Raffaele Hospital. Vita-Salute Vita-Salute San Raffaele University, Milan, ItalyDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, ItalyEuropean Reference Network ReCONNET, pavia, Italy30 Division of Rheumatology, Department of Clinical Sciences and Applied Biotechnology, University of L`Aquila, L`Aquila, Abruzzo, Italy18 Università Campus Bio-Medico di Roma Facoltà Dipartimentale di Medicina e Chirurgia, Roma, ItalyUnit of Rheumatology, Department of Medicine, ARNAS Garibaldi Hospital, Catania, ItalyUnit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), Department of Internal Medicine, IRCCS San Raffaele Hospital, Milan, ItalyDepartment of Precision Medicine, University of Campania `L. Vanvitelli`, Naples, ItalyUnit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital, Milan, Italy7Rheumatology Unit, Department of Clinical Medicine and Surgery, University Federico II, Napoli, ItalyRheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L`Aquila, L`Aquila, Italy1Scleroderma Unit, Chair of Rheumatology, University of Modena and Reggio Emilia, Modena, ItalyRheumatology Unit, Rheumatology Hospital `Madonna dello Scoglio`, Cotronei, ItalyMedicine and Rheumatology Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, ItalyMedicine & Rheumatology Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, ItalyUO Reumatologia, Ospedale di Castrovillari, Castrovillari, ItalyUOC Medicina Interna `M.Valentini`, Presidio Ospedaliero `Annunziata`, Cosenza, ItalyRheumatology Outpatient Clinic, ASP Crotone, Crotone, ItalyDepartment of Internal Medicine, Ospedale Policlinico San Martino, Genoa, ItalyDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, ItalyIRCCS, ISTITUTO ORTOPEDICO RIZZOLI, BOLOGNA, BOLOGNA, ItalyRheumatology Outpatient Clinic, Ospedale Villa Salus, Mestre, ItalyRheumatology Unit, Department of Clinical and Molecular Sciences, `Carlo Urbani` Hospital, Polytechnic University of Marche, Ancona, ItalyDepartment of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, ItalyMedicine and Rheumatology Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, ItalyMedicine & Rheumatology Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy2Sapienza University of Rome, Rome, ItalyDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, ItalyUO Reumatologia, Ospedale di Castrovillari, Castrovillari, ItalyUOSD Reumatologia ARNAS Garibaldi, Catania, ItalyRheumatology Unit, `Mauro Scarlato` Hospital, Scafati, ItalyDepartment of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum University of Bologna, Bologna, ItalyFondazione Policlinico Universitario Campus Bio-Medico, Rome, ItalyRheumatology Unit, Rheumatology Hospital `Madonna dello Scoglio`, Cotronei, ItalyUnit of Rheumatology, Department of Medicine, ARNAS Garibaldi Hospital, Catania, ItalyUO Interaziendale Medicina Interna ad Indirizzo Reumatologico, AUSL BO—IRCCS AOU BO, Bologna, ItalyObjectives To better define the spectrum of new-onset post-COVID-19 and post-COVID-19 vaccine inflammatory rheumatic diseases (IRD) from a large multicentric observational study.Methods Consecutive cases of IRD encountered during a 12-month period and satisfying one of the following inclusion criteria: (a) onset of the rheumatic manifestations within 4 weeks from SARS-CoV-2 infection or (b) onset of the rheumatic manifestations within 4 weeks from the administration of one of the COVID-19 vaccines ws recruited.Results The final analysis cohort comprised 267 patients, of which 122 (45.2%) in the post-COVID-19 and 145 (54.8%) in the postvaccine cohort. Distribution of IRD categories differed between the two cohorts: the post-COVID-19 cohort had a higher percentage of patients classified as having inflammatory joint diseases (IJD, 52.5% vs 37.2%, p=0.013) while the post-vaccine cohort had a higher prevalence of patients classified as polymyalgia rheumatica (PMR, 33.1% vs 21.3%, p=0.032). No differences were detected in the percentage of patients diagnosed with connective tissue diseases (CTD 19.7% vs 20.7%, p=0.837) or vasculitis (6.6% vs 9.0%, p=0.467). Despite the short follow-up period, IJD and PMR patients’ response to first-line therapy was favourable, with both groups achieving a drop in baseline disease activity scores of ~30% and ~70% respectively.Conclusion Our article reports the largest cohort published to date of new-onset IRD following SARS-CoV-2 infection or COVID-19 vaccines. Although causality cannot be ascertained, the spectrum of possible clinical manifestations is broad and includes IJD, PMR, CTD and vasculitis.https://rmdopen.bmj.com/content/9/2/e003022.full |
| spellingShingle | Laura Massaro Annamaria Iagnocco Florenzo Iannone Corrado Campochiaro Maria De Santis Ilaria Cavazzana Piero Ruscitti Roberto Giacomelli Rosario Foti Lorenzo Dagna Giovanna Cuomo Giacomo De Luca Francesco Caso Ilenia Di Cola Clodoveo Ferri Vincenzo Raimondo Francesco Ursini Veronica Brusi Giuseppe Varcasia Roberta Pellegrini Domenico Olivo Giuseppe Murdaca Carlo Selmi Olga Addimanda Erika Pigatto Francesca Francioso Rossella De Angelis Jacopo Ciaffi Luana Mancarella Marcella Visentini Francesca Motta Virginia Caira Alberto Lo Gullo Caterina Naclerio Elena Marchetti Sebastiano Lorusso Jessica Luppino Roberta Foti Massimo Reta Inflammatory rheumatic diseases with onset after SARS-CoV-2 infection or COVID-19 vaccination: a report of 267 cases from the COVID-19 and ASD group RMD Open |
| title | Inflammatory rheumatic diseases with onset after SARS-CoV-2 infection or COVID-19 vaccination: a report of 267 cases from the COVID-19 and ASD group |
| title_full | Inflammatory rheumatic diseases with onset after SARS-CoV-2 infection or COVID-19 vaccination: a report of 267 cases from the COVID-19 and ASD group |
| title_fullStr | Inflammatory rheumatic diseases with onset after SARS-CoV-2 infection or COVID-19 vaccination: a report of 267 cases from the COVID-19 and ASD group |
| title_full_unstemmed | Inflammatory rheumatic diseases with onset after SARS-CoV-2 infection or COVID-19 vaccination: a report of 267 cases from the COVID-19 and ASD group |
| title_short | Inflammatory rheumatic diseases with onset after SARS-CoV-2 infection or COVID-19 vaccination: a report of 267 cases from the COVID-19 and ASD group |
| title_sort | inflammatory rheumatic diseases with onset after sars cov 2 infection or covid 19 vaccination a report of 267 cases from the covid 19 and asd group |
| url | https://rmdopen.bmj.com/content/9/2/e003022.full |
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