DHA Supplementation during Pregnancy and Lactation Affects Infants' Cellular but Not Humoral Immune Response
Background. It is currently recommended that diet of pregnant mothers contain 200–300 mg DHA/day. Aim. To determine whether DHA supplementation during pregnancy and lactation affects infants' immune response. Methods. 60 women in ≥3rd pregnancy studied; 30 randomly assigned to receive DHA 400 m...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2011/493925 |
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| author | Esther Granot Einat Jakobovich Ruth Rabinowitz Paloma Levy Michael Schlesinger |
| author_facet | Esther Granot Einat Jakobovich Ruth Rabinowitz Paloma Levy Michael Schlesinger |
| author_sort | Esther Granot |
| collection | DOAJ |
| description | Background. It is currently recommended that diet of pregnant mothers contain 200–300 mg DHA/day. Aim. To determine whether DHA supplementation during pregnancy and lactation affects infants' immune response. Methods. 60 women in ≥3rd pregnancy studied; 30 randomly assigned to receive DHA 400 mg/day from 12th week gestation until 4 months postpartum. From breast-fed infants, blood obtained for anti-HBs antibodies, immunoglobulins, lymphocyte subset phenotyping, and intracellular cytokine production. Results. CD4+ lymphocytes did not differ between groups, but CD4CD45RA/CD4 (naïve cells) significantly higher in infants in DHA+ group. Proportion of CD4 and CD8 cells producing IFNγ significantly lower in DHA+ group, with no differences in proportion of IL4-producing cells. Immunoglobulins and anti-HBs levels did not differ between groups. Conclusions. In infants of mothers receiving DHA supplementation, a higher percentage of CD4 naïve cells and decreased CD4 and CD8 IFNγ production is compatible with attenuation of a proinflammatory response. |
| format | Article |
| id | doaj-art-b4596a39306d417dae7c7937136f262c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b4596a39306d417dae7c7937136f262c2025-02-03T00:59:13ZengWileyMediators of Inflammation0962-93511466-18612011-01-01201110.1155/2011/493925493925DHA Supplementation during Pregnancy and Lactation Affects Infants' Cellular but Not Humoral Immune ResponseEsther Granot0Einat Jakobovich1Ruth Rabinowitz2Paloma Levy3Michael Schlesinger4Department of Pediatrics, Kaplan Medical Center, P.O. Box 1, Rehovot, IsraelDepartment of Pediatrics, Kaplan Medical Center, P.O. Box 1, Rehovot, IsraelDepartment of Developmental Biology and Cancer Research, Hadassah Medical School, Hebrew University, Jerusalem, IsraelDepartment of Developmental Biology and Cancer Research, Hadassah Medical School, Hebrew University, Jerusalem, IsraelDepartment of Developmental Biology and Cancer Research, Hadassah Medical School, Hebrew University, Jerusalem, IsraelBackground. It is currently recommended that diet of pregnant mothers contain 200–300 mg DHA/day. Aim. To determine whether DHA supplementation during pregnancy and lactation affects infants' immune response. Methods. 60 women in ≥3rd pregnancy studied; 30 randomly assigned to receive DHA 400 mg/day from 12th week gestation until 4 months postpartum. From breast-fed infants, blood obtained for anti-HBs antibodies, immunoglobulins, lymphocyte subset phenotyping, and intracellular cytokine production. Results. CD4+ lymphocytes did not differ between groups, but CD4CD45RA/CD4 (naïve cells) significantly higher in infants in DHA+ group. Proportion of CD4 and CD8 cells producing IFNγ significantly lower in DHA+ group, with no differences in proportion of IL4-producing cells. Immunoglobulins and anti-HBs levels did not differ between groups. Conclusions. In infants of mothers receiving DHA supplementation, a higher percentage of CD4 naïve cells and decreased CD4 and CD8 IFNγ production is compatible with attenuation of a proinflammatory response.http://dx.doi.org/10.1155/2011/493925 |
| spellingShingle | Esther Granot Einat Jakobovich Ruth Rabinowitz Paloma Levy Michael Schlesinger DHA Supplementation during Pregnancy and Lactation Affects Infants' Cellular but Not Humoral Immune Response Mediators of Inflammation |
| title | DHA Supplementation during Pregnancy and Lactation Affects Infants' Cellular but Not Humoral Immune Response |
| title_full | DHA Supplementation during Pregnancy and Lactation Affects Infants' Cellular but Not Humoral Immune Response |
| title_fullStr | DHA Supplementation during Pregnancy and Lactation Affects Infants' Cellular but Not Humoral Immune Response |
| title_full_unstemmed | DHA Supplementation during Pregnancy and Lactation Affects Infants' Cellular but Not Humoral Immune Response |
| title_short | DHA Supplementation during Pregnancy and Lactation Affects Infants' Cellular but Not Humoral Immune Response |
| title_sort | dha supplementation during pregnancy and lactation affects infants cellular but not humoral immune response |
| url | http://dx.doi.org/10.1155/2011/493925 |
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