Application of Physiologically Based Pharmacokinetic Models in Chemical Risk Assessment
Post-exposure risk assessment of chemical and environmental stressors is a public health challenge. Linking exposure to health outcomes is a 4-step process: exposure assessment, hazard identification, dose response assessment, and risk characterization. This process is increasingly adopting “in sili...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2012/904603 |
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| _version_ | 1832555877354176512 |
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| author | Moiz Mumtaz Jeffrey Fisher Benjamin Blount Patricia Ruiz |
| author_facet | Moiz Mumtaz Jeffrey Fisher Benjamin Blount Patricia Ruiz |
| author_sort | Moiz Mumtaz |
| collection | DOAJ |
| description | Post-exposure risk assessment of chemical and environmental stressors is a public health challenge. Linking exposure to health outcomes is a 4-step process: exposure assessment, hazard identification, dose response assessment, and risk characterization. This process is increasingly adopting “in silico” tools such as physiologically based pharmacokinetic (PBPK) models to fine-tune exposure assessments and determine internal doses in target organs/tissues. Many excellent PBPK models have been developed. But most, because of their scientific sophistication, have found limited field application—health assessors rarely use them. Over the years, government agencies, stakeholders/partners, and the scientific community have attempted to use these models or their underlying principles in combination with other practical procedures. During the past two decades, through cooperative agreements and contracts at several research and higher education institutions, ATSDR funded translational research has encouraged the use of various types of models. Such collaborative efforts have led to the development and use of transparent and user-friendly models. The “human PBPK model toolkit” is one such project. While not necessarily state of the art, this toolkit is sufficiently accurate for screening purposes. Highlighted in this paper are some selected examples of environmental and occupational exposure assessments of chemicals and their mixtures. |
| format | Article |
| id | doaj-art-b44b3df557cc401db7033d6a8d404cd4 |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-b44b3df557cc401db7033d6a8d404cd42025-02-03T05:47:04ZengWileyJournal of Toxicology1687-81911687-82052012-01-01201210.1155/2012/904603904603Application of Physiologically Based Pharmacokinetic Models in Chemical Risk AssessmentMoiz Mumtaz0Jeffrey Fisher1Benjamin Blount2Patricia Ruiz3Computational Toxicology and Methods Development Laboratory, Division of Toxicology and Environmental Medicine (DTEM), Agency for Toxic Substances and Disease Registry (ATSDR), Atlanta, GA 30333, USANational Center for Toxicological Research, USFDA, Jefferson, AR 72079, USADivision of Laboratory Studies, National Center for Environmental Health, Centers for Disease Control and Prevention (CDC), Atlanta, GA 30341, USAComputational Toxicology and Methods Development Laboratory, Division of Toxicology and Environmental Medicine (DTEM), Agency for Toxic Substances and Disease Registry (ATSDR), Atlanta, GA 30333, USAPost-exposure risk assessment of chemical and environmental stressors is a public health challenge. Linking exposure to health outcomes is a 4-step process: exposure assessment, hazard identification, dose response assessment, and risk characterization. This process is increasingly adopting “in silico” tools such as physiologically based pharmacokinetic (PBPK) models to fine-tune exposure assessments and determine internal doses in target organs/tissues. Many excellent PBPK models have been developed. But most, because of their scientific sophistication, have found limited field application—health assessors rarely use them. Over the years, government agencies, stakeholders/partners, and the scientific community have attempted to use these models or their underlying principles in combination with other practical procedures. During the past two decades, through cooperative agreements and contracts at several research and higher education institutions, ATSDR funded translational research has encouraged the use of various types of models. Such collaborative efforts have led to the development and use of transparent and user-friendly models. The “human PBPK model toolkit” is one such project. While not necessarily state of the art, this toolkit is sufficiently accurate for screening purposes. Highlighted in this paper are some selected examples of environmental and occupational exposure assessments of chemicals and their mixtures.http://dx.doi.org/10.1155/2012/904603 |
| spellingShingle | Moiz Mumtaz Jeffrey Fisher Benjamin Blount Patricia Ruiz Application of Physiologically Based Pharmacokinetic Models in Chemical Risk Assessment Journal of Toxicology |
| title | Application of Physiologically Based Pharmacokinetic Models in Chemical Risk Assessment |
| title_full | Application of Physiologically Based Pharmacokinetic Models in Chemical Risk Assessment |
| title_fullStr | Application of Physiologically Based Pharmacokinetic Models in Chemical Risk Assessment |
| title_full_unstemmed | Application of Physiologically Based Pharmacokinetic Models in Chemical Risk Assessment |
| title_short | Application of Physiologically Based Pharmacokinetic Models in Chemical Risk Assessment |
| title_sort | application of physiologically based pharmacokinetic models in chemical risk assessment |
| url | http://dx.doi.org/10.1155/2012/904603 |
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