Infliximab Induces Increase in Triglyceride Levels in Psoriatic Arthritis Patients
Objectives. To evaluate lipid profile changes after anti-TNF therapy in patients with psoriatic arthritis (PsA). Methods. Fifteen PsA patients (eight polyarticular, four oligoarticular, two axial, and one mutilating) under infliximab were included. None had dyslipoproteinemia or previous statin use....
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/352686 |
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| author | Karla R. Castro Nádia E. Aikawa Carla Gonçalves Saad Júlio C. B. Moraes Ana C. Medeiros Licia Maria H. Mota Clovis A. A. Silva Eloísa Bonfá Jozélio F. Carvalho |
| author_facet | Karla R. Castro Nádia E. Aikawa Carla Gonçalves Saad Júlio C. B. Moraes Ana C. Medeiros Licia Maria H. Mota Clovis A. A. Silva Eloísa Bonfá Jozélio F. Carvalho |
| author_sort | Karla R. Castro |
| collection | DOAJ |
| description | Objectives. To evaluate lipid profile changes after anti-TNF therapy in patients with psoriatic arthritis (PsA). Methods. Fifteen PsA patients (eight polyarticular, four oligoarticular, two axial, and one mutilating) under infliximab were included. None had dyslipoproteinemia or previous statin use. Total cholesterol (TC) and its fractions, inflammatory markers, and prednisone use were evaluated. Results. The comparisons of lipid levels between baseline and after three months (3M) of anti-TNF therapy showed that there was a significant increase in mean triglycerides (117.8±49.7 versus 140.1±64.1 mg/dL, P=0.028) and VLDL-c (23.6±10.5 versus 28.4±13.7 mg/dL, P=0.019) levels. In contrast, there were no differences in the mean TC (P=0.28), LDL-c (P=0.42), and HDL-c (P=0.26) levels. Analysis of the frequencies of each lipid alteration at baseline and at 3M were alike (P>0.05). Positive correlations were found between VLDL-c and CRP (r=0.647, P=0.009) and between triglycerides and CRP (r=0.604, P=0.017) levels at 3M. ESR reduction was observed after 3M (P=0.04). Mean prednisone dose remained stable at beginning and at 3M (P=0.37). Conclusion. This study demonstrated that anti-TNF may increase TG and VLDL-c levels in PsA patients after three months. |
| format | Article |
| id | doaj-art-b43b5cbb41344064b0b2f53592d5a5ea |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-b43b5cbb41344064b0b2f53592d5a5ea2025-02-03T01:24:53ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/352686352686Infliximab Induces Increase in Triglyceride Levels in Psoriatic Arthritis PatientsKarla R. Castro0Nádia E. Aikawa1Carla Gonçalves Saad2Júlio C. B. Moraes3Ana C. Medeiros4Licia Maria H. Mota5Clovis A. A. Silva6Eloísa Bonfá7Jozélio F. Carvalho8Rheumatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (CEDMAC), 01246-903 São Paulo, SP, BrazilRheumatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (CEDMAC), 01246-903 São Paulo, SP, BrazilRheumatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (CEDMAC), 01246-903 São Paulo, SP, BrazilRheumatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (CEDMAC), 01246-903 São Paulo, SP, BrazilRheumatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (CEDMAC), 01246-903 São Paulo, SP, BrazilRheumatology Division, University Hospital of Brasília, Universidade de Brasília, 71660020 Brasília, DF, BrazilRheumatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (CEDMAC), 01246-903 São Paulo, SP, BrazilRheumatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (CEDMAC), 01246-903 São Paulo, SP, BrazilRheumatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (CEDMAC), 01246-903 São Paulo, SP, BrazilObjectives. To evaluate lipid profile changes after anti-TNF therapy in patients with psoriatic arthritis (PsA). Methods. Fifteen PsA patients (eight polyarticular, four oligoarticular, two axial, and one mutilating) under infliximab were included. None had dyslipoproteinemia or previous statin use. Total cholesterol (TC) and its fractions, inflammatory markers, and prednisone use were evaluated. Results. The comparisons of lipid levels between baseline and after three months (3M) of anti-TNF therapy showed that there was a significant increase in mean triglycerides (117.8±49.7 versus 140.1±64.1 mg/dL, P=0.028) and VLDL-c (23.6±10.5 versus 28.4±13.7 mg/dL, P=0.019) levels. In contrast, there were no differences in the mean TC (P=0.28), LDL-c (P=0.42), and HDL-c (P=0.26) levels. Analysis of the frequencies of each lipid alteration at baseline and at 3M were alike (P>0.05). Positive correlations were found between VLDL-c and CRP (r=0.647, P=0.009) and between triglycerides and CRP (r=0.604, P=0.017) levels at 3M. ESR reduction was observed after 3M (P=0.04). Mean prednisone dose remained stable at beginning and at 3M (P=0.37). Conclusion. This study demonstrated that anti-TNF may increase TG and VLDL-c levels in PsA patients after three months.http://dx.doi.org/10.1155/2011/352686 |
| spellingShingle | Karla R. Castro Nádia E. Aikawa Carla Gonçalves Saad Júlio C. B. Moraes Ana C. Medeiros Licia Maria H. Mota Clovis A. A. Silva Eloísa Bonfá Jozélio F. Carvalho Infliximab Induces Increase in Triglyceride Levels in Psoriatic Arthritis Patients Clinical and Developmental Immunology |
| title | Infliximab Induces Increase in Triglyceride Levels in Psoriatic Arthritis Patients |
| title_full | Infliximab Induces Increase in Triglyceride Levels in Psoriatic Arthritis Patients |
| title_fullStr | Infliximab Induces Increase in Triglyceride Levels in Psoriatic Arthritis Patients |
| title_full_unstemmed | Infliximab Induces Increase in Triglyceride Levels in Psoriatic Arthritis Patients |
| title_short | Infliximab Induces Increase in Triglyceride Levels in Psoriatic Arthritis Patients |
| title_sort | infliximab induces increase in triglyceride levels in psoriatic arthritis patients |
| url | http://dx.doi.org/10.1155/2011/352686 |
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