Genome-wide determinants of proviral targeting, clonal abundance and expression in natural HTLV-1 infection.

The regulation of proviral latency is a central problem in retrovirology. We postulate that the genomic integration site of human T lymphotropic virus type 1 (HTLV-1) determines the pattern of expression of the provirus, which in turn determines the abundance and pathogenic potential of infected T c...

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Bibliographic Details
Main Authors: Anat Melamed, Daniel J Laydon, Nicolas A Gillet, Yuetsu Tanaka, Graham P Taylor, Charles R M Bangham
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1003271
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