Ultrasonographic assessment of optic nerve: does it help in lupus-induced optic neuropathy?
Objective Evaluating the potential role of neuromuscular ultrasonography (NMUS) in assessing optic nerve affection in patients with systemic lupus erythematosus (SLE), compared with healthy controls and other conventional strategies in diagnosing optic neuropathy.Methods We conducted an observationa...
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| Language: | English |
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BMJ Publishing Group
2025-01-01
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| Series: | Lupus Science and Medicine |
| Online Access: | https://lupus.bmj.com/content/12/1/e001358.full |
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| author | Amira Elsonbaty Abdallah El-Sayed Allam Doaa M Mahmoud Sara Alattar Ahmed Hosny Shaaban |
| author_facet | Amira Elsonbaty Abdallah El-Sayed Allam Doaa M Mahmoud Sara Alattar Ahmed Hosny Shaaban |
| author_sort | Amira Elsonbaty |
| collection | DOAJ |
| description | Objective Evaluating the potential role of neuromuscular ultrasonography (NMUS) in assessing optic nerve affection in patients with systemic lupus erythematosus (SLE), compared with healthy controls and other conventional strategies in diagnosing optic neuropathy.Methods We conducted an observational cross-sectional study comparing patients with SLE and a healthy group. We measured the optic nerve diameter (OND) and optic nerve sheath diameter (ONSD) and calculated the OND/ONSD ratio and side-to-side difference. An ophthalmologist examined all lupus patients and visual evoked potential (VEP) was performed to help evaluate the rule of NMUS in lupus-induced optic neuropathy.Results In this study, we include 140 subjects, 65 lupus patients and 75 controls. Significant enlargement was present among lupus patients OND and ONSD (p= 0.017, 0.004, respectively) in comparison to controls; ultrasonographic evaluation had a high specificity when compared to ophthalmological evaluation and VEP reaching 89.6% and 88.1%, respectively, but with very low sensitivity.Conclusion Ultrasonographic evaluation of the optic nerve may add significant value to the diagnosis of optic neuropathy in patients with SLE and should be considered a complementary tool to other conventional methods. |
| format | Article |
| id | doaj-art-b4228f68e76b479b95102ad2d46b1961 |
| institution | Kabale University |
| issn | 2053-8790 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Lupus Science and Medicine |
| spelling | doaj-art-b4228f68e76b479b95102ad2d46b19612025-01-22T05:15:09ZengBMJ Publishing GroupLupus Science and Medicine2053-87902025-01-0112110.1136/lupus-2024-001358Ultrasonographic assessment of optic nerve: does it help in lupus-induced optic neuropathy?Amira Elsonbaty0Abdallah El-Sayed Allam1Doaa M Mahmoud2Sara Alattar3Ahmed Hosny Shaaban4Department of Rheumatology, Rehabilitation and Physical Medicine, Assiut University, Assuit, EgyptPhysical Medicine, Rheumatology & Rehabilitation, School of Medicine, Tanta University, Tanta, EgyptDepartment of Neurology and Psychiatry, Assiut University Hospital, Assiut, EgyptDepartment of Ophthalmology, Assiut University Hospital, Assiut, EgyptDepartment of Ophthalmology, Assiut University Student’s Hospital, Assiut University Faculty of Medicine, Assiut, EgyptObjective Evaluating the potential role of neuromuscular ultrasonography (NMUS) in assessing optic nerve affection in patients with systemic lupus erythematosus (SLE), compared with healthy controls and other conventional strategies in diagnosing optic neuropathy.Methods We conducted an observational cross-sectional study comparing patients with SLE and a healthy group. We measured the optic nerve diameter (OND) and optic nerve sheath diameter (ONSD) and calculated the OND/ONSD ratio and side-to-side difference. An ophthalmologist examined all lupus patients and visual evoked potential (VEP) was performed to help evaluate the rule of NMUS in lupus-induced optic neuropathy.Results In this study, we include 140 subjects, 65 lupus patients and 75 controls. Significant enlargement was present among lupus patients OND and ONSD (p= 0.017, 0.004, respectively) in comparison to controls; ultrasonographic evaluation had a high specificity when compared to ophthalmological evaluation and VEP reaching 89.6% and 88.1%, respectively, but with very low sensitivity.Conclusion Ultrasonographic evaluation of the optic nerve may add significant value to the diagnosis of optic neuropathy in patients with SLE and should be considered a complementary tool to other conventional methods.https://lupus.bmj.com/content/12/1/e001358.full |
| spellingShingle | Amira Elsonbaty Abdallah El-Sayed Allam Doaa M Mahmoud Sara Alattar Ahmed Hosny Shaaban Ultrasonographic assessment of optic nerve: does it help in lupus-induced optic neuropathy? Lupus Science and Medicine |
| title | Ultrasonographic assessment of optic nerve: does it help in lupus-induced optic neuropathy? |
| title_full | Ultrasonographic assessment of optic nerve: does it help in lupus-induced optic neuropathy? |
| title_fullStr | Ultrasonographic assessment of optic nerve: does it help in lupus-induced optic neuropathy? |
| title_full_unstemmed | Ultrasonographic assessment of optic nerve: does it help in lupus-induced optic neuropathy? |
| title_short | Ultrasonographic assessment of optic nerve: does it help in lupus-induced optic neuropathy? |
| title_sort | ultrasonographic assessment of optic nerve does it help in lupus induced optic neuropathy |
| url | https://lupus.bmj.com/content/12/1/e001358.full |
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