Cannabigerol (CBG): A Comprehensive Review of Its Molecular Mechanisms and Therapeutic Potential
Cannabigerol (CBG), a non-psychoactive cannabinoid found in cannabis, has emerged as a promising therapeutic agent with a diverse range of potential applications. Unlike its well-known counterpart tetrahydrocannabinol (THC), CBG does not induce intoxication, making it an attractive option in the cli...
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MDPI AG
2024-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/29/22/5471 |
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| author | Shijia Li Weini Li Naseeb Kaur Malhi Junwei Huang Quanqi Li Ziwei Zhou Ruiheng Wang Jiangling Peng Tong Yin Honggen Wang |
| author_facet | Shijia Li Weini Li Naseeb Kaur Malhi Junwei Huang Quanqi Li Ziwei Zhou Ruiheng Wang Jiangling Peng Tong Yin Honggen Wang |
| author_sort | Shijia Li |
| collection | DOAJ |
| description | Cannabigerol (CBG), a non-psychoactive cannabinoid found in cannabis, has emerged as a promising therapeutic agent with a diverse range of potential applications. Unlike its well-known counterpart tetrahydrocannabinol (THC), CBG does not induce intoxication, making it an attractive option in the clinic. Recent research has shed light on CBG’s intriguing molecular mechanisms, highlighting its potential to modulate multiple physiological processes. This review delves into the current understanding of CBG’s molecular interactions and explores its therapeutic power to alleviate various conditions, including cancer, metabolic, pain, and inflammatory disorders, amongst others. We discuss how CBG interacts with the endocannabinoid system and other key signaling pathways, such as CB1, CB2, TPR channels, and α2-adrenoceptor, potentially influencing inflammation, pain, neurodegeneration, and other ailments. Additionally, we highlight the ongoing research efforts aimed at elucidating the full spectrum of CBG’s therapeutic potential and its safety profile in clinical settings. Through this comprehensive analysis, we aim to provide a deeper understanding of CBG’s role in promoting human health and pave the way for future research endeavors. |
| format | Article |
| id | doaj-art-b40c8e91ea9445f3bdbdfb7f41f6f91e |
| institution | OA Journals |
| issn | 1420-3049 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-b40c8e91ea9445f3bdbdfb7f41f6f91e2025-08-20T01:53:54ZengMDPI AGMolecules1420-30492024-11-012922547110.3390/molecules29225471Cannabigerol (CBG): A Comprehensive Review of Its Molecular Mechanisms and Therapeutic PotentialShijia Li0Weini Li1Naseeb Kaur Malhi2Junwei Huang3Quanqi Li4Ziwei Zhou5Ruiheng Wang6Jiangling Peng7Tong Yin8Honggen Wang9School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, ChinaDepartment of Biomedical Science, Cedars-Sinai Medical Center, Cedars-Sinai Cancer Institute, Los Angeles, CA 90067, USADepartment of Diabetes Complications and Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute of City of Hope, Duarte, CA 91010, USASchool of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, ChinaSchool of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, ChinaSchool of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, ChinaDepartment of Biomedical Science, Cedars-Sinai Medical Center, Cedars-Sinai Cancer Institute, Los Angeles, CA 90067, USASchool of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, ChinaSouth China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, ChinaCannabigerol (CBG), a non-psychoactive cannabinoid found in cannabis, has emerged as a promising therapeutic agent with a diverse range of potential applications. Unlike its well-known counterpart tetrahydrocannabinol (THC), CBG does not induce intoxication, making it an attractive option in the clinic. Recent research has shed light on CBG’s intriguing molecular mechanisms, highlighting its potential to modulate multiple physiological processes. This review delves into the current understanding of CBG’s molecular interactions and explores its therapeutic power to alleviate various conditions, including cancer, metabolic, pain, and inflammatory disorders, amongst others. We discuss how CBG interacts with the endocannabinoid system and other key signaling pathways, such as CB1, CB2, TPR channels, and α2-adrenoceptor, potentially influencing inflammation, pain, neurodegeneration, and other ailments. Additionally, we highlight the ongoing research efforts aimed at elucidating the full spectrum of CBG’s therapeutic potential and its safety profile in clinical settings. Through this comprehensive analysis, we aim to provide a deeper understanding of CBG’s role in promoting human health and pave the way for future research endeavors.https://www.mdpi.com/1420-3049/29/22/5471Cannabigerol (CBG)endocannabinoid systemcannabinoid receptormolecular mechanism |
| spellingShingle | Shijia Li Weini Li Naseeb Kaur Malhi Junwei Huang Quanqi Li Ziwei Zhou Ruiheng Wang Jiangling Peng Tong Yin Honggen Wang Cannabigerol (CBG): A Comprehensive Review of Its Molecular Mechanisms and Therapeutic Potential Molecules Cannabigerol (CBG) endocannabinoid system cannabinoid receptor molecular mechanism |
| title | Cannabigerol (CBG): A Comprehensive Review of Its Molecular Mechanisms and Therapeutic Potential |
| title_full | Cannabigerol (CBG): A Comprehensive Review of Its Molecular Mechanisms and Therapeutic Potential |
| title_fullStr | Cannabigerol (CBG): A Comprehensive Review of Its Molecular Mechanisms and Therapeutic Potential |
| title_full_unstemmed | Cannabigerol (CBG): A Comprehensive Review of Its Molecular Mechanisms and Therapeutic Potential |
| title_short | Cannabigerol (CBG): A Comprehensive Review of Its Molecular Mechanisms and Therapeutic Potential |
| title_sort | cannabigerol cbg a comprehensive review of its molecular mechanisms and therapeutic potential |
| topic | Cannabigerol (CBG) endocannabinoid system cannabinoid receptor molecular mechanism |
| url | https://www.mdpi.com/1420-3049/29/22/5471 |
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