Enhanced antitumor efficacy through sustained release of 5-fluorouracil from poly(trimethylene carbonate) membranes
IntroductionCancer remains one of the deadliest diseases worldwide. 5-Fluorouracil (5-FU) is one of the most commonly used chemotherapeutic agents in clinical practice today, but its effectiveness is often hampered by rapid drug metabolism and systemic toxicity. To address these limitations, the dev...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1536764/full |
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| author | Zongheng Wang Zhipeng Hou Shuguang Zhang Shuangyi Ren Liqun Yang Qianshi Zhang |
| author_facet | Zongheng Wang Zhipeng Hou Shuguang Zhang Shuangyi Ren Liqun Yang Qianshi Zhang |
| author_sort | Zongheng Wang |
| collection | DOAJ |
| description | IntroductionCancer remains one of the deadliest diseases worldwide. 5-Fluorouracil (5-FU) is one of the most commonly used chemotherapeutic agents in clinical practice today, but its effectiveness is often hampered by rapid drug metabolism and systemic toxicity. To address these limitations, the development of novel drug delivery systems for sustained drug release is essential to improve therapeutic outcomes.MethodsThis study aimed to develop a poly(trimethylene carbonate) (PTMC) membrane capable of sustained drug release of 5-FU to enhance its antitumor activity. The membranes were prepared using the solvent-casting method, and their comprehensive properties were characterized.Results and DiscussionWe evaluated the in vitro sustained release capability, as well as the biocompatibility and antitumor activity at both cellular and animal levels. The results demonstrated that the 5-FU-loaded PTMC membranes exhibited effective sustained release capabilities, superior biocompatibility, and enhanced antitumor effects compared to the 5-FU injections. These findings suggested that the 5-FU-loaded PTMC membranes hold great potential for application in cancer patients, offering benefits in chemotherapy treatment. |
| format | Article |
| id | doaj-art-b4017ec4fe3b4b70a422b783e0676133 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-b4017ec4fe3b4b70a422b783e06761332025-01-20T09:37:02ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.15367641536764Enhanced antitumor efficacy through sustained release of 5-fluorouracil from poly(trimethylene carbonate) membranesZongheng Wang0Zhipeng Hou1Shuguang Zhang2Shuangyi Ren3Liqun Yang4Qianshi Zhang5Department of Gastrointestinal Surgery, The Second Hospital of Dalian Medical University, Dalian, ChinaResearch Center for Biomedical Materials, Shenyang Key Laboratory of Biomedical Polymers, Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic Techniques, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Thoracic Surgery, The First Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Gastrointestinal Surgery, The Second Hospital of Dalian Medical University, Dalian, ChinaResearch Center for Biomedical Materials, Shenyang Key Laboratory of Biomedical Polymers, Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic Techniques, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Gastrointestinal Surgery, The Second Hospital of Dalian Medical University, Dalian, ChinaIntroductionCancer remains one of the deadliest diseases worldwide. 5-Fluorouracil (5-FU) is one of the most commonly used chemotherapeutic agents in clinical practice today, but its effectiveness is often hampered by rapid drug metabolism and systemic toxicity. To address these limitations, the development of novel drug delivery systems for sustained drug release is essential to improve therapeutic outcomes.MethodsThis study aimed to develop a poly(trimethylene carbonate) (PTMC) membrane capable of sustained drug release of 5-FU to enhance its antitumor activity. The membranes were prepared using the solvent-casting method, and their comprehensive properties were characterized.Results and DiscussionWe evaluated the in vitro sustained release capability, as well as the biocompatibility and antitumor activity at both cellular and animal levels. The results demonstrated that the 5-FU-loaded PTMC membranes exhibited effective sustained release capabilities, superior biocompatibility, and enhanced antitumor effects compared to the 5-FU injections. These findings suggested that the 5-FU-loaded PTMC membranes hold great potential for application in cancer patients, offering benefits in chemotherapy treatment.https://www.frontiersin.org/articles/10.3389/fphar.2024.1536764/fullpoly(trimethylene carbonate)sustained drug release system5-fluorouracilcolorectal cancerantitumor efficacy |
| spellingShingle | Zongheng Wang Zhipeng Hou Shuguang Zhang Shuangyi Ren Liqun Yang Qianshi Zhang Enhanced antitumor efficacy through sustained release of 5-fluorouracil from poly(trimethylene carbonate) membranes Frontiers in Pharmacology poly(trimethylene carbonate) sustained drug release system 5-fluorouracil colorectal cancer antitumor efficacy |
| title | Enhanced antitumor efficacy through sustained release of 5-fluorouracil from poly(trimethylene carbonate) membranes |
| title_full | Enhanced antitumor efficacy through sustained release of 5-fluorouracil from poly(trimethylene carbonate) membranes |
| title_fullStr | Enhanced antitumor efficacy through sustained release of 5-fluorouracil from poly(trimethylene carbonate) membranes |
| title_full_unstemmed | Enhanced antitumor efficacy through sustained release of 5-fluorouracil from poly(trimethylene carbonate) membranes |
| title_short | Enhanced antitumor efficacy through sustained release of 5-fluorouracil from poly(trimethylene carbonate) membranes |
| title_sort | enhanced antitumor efficacy through sustained release of 5 fluorouracil from poly trimethylene carbonate membranes |
| topic | poly(trimethylene carbonate) sustained drug release system 5-fluorouracil colorectal cancer antitumor efficacy |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1536764/full |
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