Lipolysis-derived fatty acids are needed for homeostatic control of sterol element-binding protein-1c driven hepatic lipogenesis

Lipolysis-derived fatty acids are needed for homeostatic control of sterol element-binding protein-1c driven hepatic lipogenesis

Abstract Sterol Regulatory Element-Binding Protein-1c (SREBP-1c) is translated as an inactive precursor (P-SREBP-1c) postprandially. Low levels of unsaturated fatty acids (uFAs) and high insulin promote its proteolytic activation, yielding N-SREBP-1c that drives fatty acid (FA) biosynthesis. During...

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Main Authors: Paola Peña de la Sancha, Beatrix Irene Wieser, Silvia Schauer, Helga Reicher, Wolfgang Sattler, Rolf Breinbauer, Martina Schweiger, Margarete Lechleitner, Saša Frank, Rudolf Zechner, Dagmar Kratky, Peter John Espenshade, Gerald Hoefler, Paul Willibald Vesely
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08002-1
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https://doi.org/10.1038/s42003-025-08002-1

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