Robust substrate profiling method reveals striking differences in specificities of serum and lung fluid proteases

Proteases are candidate biomarkers and therapeutic targets for many diseases. Sensitive and robust techniques are needed to quantify proteolytic activities within the complex biological milieu. We hypothesized that a combinatorial protease substrate library could be used effectively to identify simi...

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Bibliographic Details
Main Authors: Douglas S. Watson, Kalyani Jambunathan, David S. Askew, Krishna Kodukula, Amit K. Galande
Format: Article
Language:English
Published: Taylor & Francis Group 2011-08-01
Series:BioTechniques
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Online Access:https://www.future-science.com/doi/10.2144/000113717
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